Matches 251 - 300 out of 493 < 1 2 3 4 5 6 7 8 9 10 >
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5614548 Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions  
Quaternary amine-containing ether lipid analogs of the formula R 1 --X--R 2 --N + (R 3 ) (R 4 ) (R 5 ) Z - are disclosed. R 1 represents a hydrophobic group and R 2 represents the backbone...
5612378 Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors  
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and...
5607931 1,2-disubstituted ethly amides as inhibitors of ACAT  
Amides of the formula ##STR1## wherein: R 1 is A and R 2 is B; R 1 is B and R 2 is A; or R 1 and R 2 are independently selected from the group B; A is phenyl, substituted phenyl,...
5565457 Substituted sulfonamides  
The compounds are N-(2,3,4-trimethoxybenzyl)piperazines N'-substituted by a radical containing a sulfonamide group, and pharmaceutically tolerable salts thereof, useful for treating myocardial...
5554641 Nonpeptides as tachykinin antagonists  
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK 3 antagonists expected to be useful in the treatment of pain,...
5545614 Controlling nitrogen oxide concentrations to modulate skeletal muscle contraction  
A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a...
5534533 Carboxylate derivatives exhibiting phospholipase A2 inhibitory activity  
Novel carboxylate derivatives exhibiting phospholipase A 2 inhibitory activity are disclosed, Specifically, the following compounds of the formula and pharmaceutically acceptable salts thereof are...
5523303 Trisubstituted cycloalkane derivatives and process for the preparation thereof  
The invention relates to novel, pharmaceutically active trisubstituted cycloalkane derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The...
5523316 Intraocular irrigating solution containing agent for controlling IOP  
Improved ophthalmic irrigating solutions are described. The solutions include one or more drugs for controlling intraocular pressure, an antioxidant/free radical scavenger, electrolytes, a cellular...
5486528 Basic ethers and process for the preparation thereof  
Novel basic ether of general formula (I), ##STR1## wherein R 1 and R 2 are independently hydrogen, halogen or C 1 -4 alkoxy, or together they represent a 3,4-methylenedioxy group, R stands for...
5444082 3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same  
3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular...
5439908 Diazinyl butyric acid amides and esters  
Compounds of the formula ##STR1## wherein A is a substituted or unsubstituted, aromatic or non-aromatic, monocyclic or bicyclic, heterocyclic radical that is bonded by way of a carbon atom to X;...
5439940 Benz[e]indene derivatives  
The invention relates to novel, pharmaceutically active benz[e]indene derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, further to the use of the...
5432168 Method of treatment of hormone-unresponsive metastatic prostate cancer  
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
5424323 Sterilant composition  
A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde...
5424309 N-substituted acylamino acid compounds, process for their production and their use  
The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
5420164 Cycloalkylurea compounds  
A cycloalkylurea compound of the formula (I): ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, which compound inhibits ACAT and is...
5385948 Alkoxyalkyl lactams as solvents for macro and microemulsions  
A solvent for producing emulsifiable concentrates from agriculturally active chemicals which are insoluble in water comprises an alkoxyalkyl lactam such as butoxy propyl pyrrolidone. An...
5373008 Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents  
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R 1 and R 2 are each aliphatic or cycloalkyl or NR 1 R 2 is an optionally substituted heterocyclic ring, R 3 is alkyl,...
5356895 1,4 piperizino inhibitors of non-enzymatic cross-linking of proteins  
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises; an agent capable of...
5354726 Delivery system for agricultural chemicals  
An emulsifiable concentrate of agriculturally active chemical which, upon dilution, produces a highly stable emulsion and avoids precipitation of the active ingredient on extended storage. The...
5346896 1-(aryl or heteroaryl)-4[ω-(aryl or heteroaryl)ω-(aryl or heteroaryl)alkylene]piperazines  
Disclosed herein are piperazine derivatives of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein W is (CH 2 ) m , CHOH or O, m is one of the integers 1 or...
5344845 Compound and use of the same as medicine  
Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds...
5340823 Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same  
A method of treating a mammalian subject for Parkinson's disease or to provide a central muscle relaxant effect, which comprises the step of administering to the mammalian subject in need of the...
5328906 0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same  
Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
5324728 Naphthoic acid derivative  
A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R 1 , R 2 and R 3 are each independently a hydrogen atom, a halogen atom, a hydroxyl...
5321031 1,2-disubstituted ethyl amides as inhibitors of ACAT  
Amides of the formula ##STR1## wherein: R 1 is A and R 2 is B; R 1 is B and R 2 is A; or R 1 and R 2 are independently selected from the group B; A is phenyl, substituted phenyl,...
5283246 Trimetazidine compounds  
The compounds are substituted trimetazidine useful for the treatment of ischaemic pathologies and peripheral vascular pathology. A compound disclosed is...
5281598 Piperazine derivatives  
The invention relates to a piperazine derivative having the formula ##STR1## wherein each φ is a phenyl group which may independently be substituted by one or more substituents selected from the...
5270310 N-aminoalkyl amide inhibitors of protein kinase C  
The present invention provides methods for inhibiting protein kinase C which comprise contacting protein kinase C with an inhibitory amount of a compound having the formula ##STR1## wherein R 1 is...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
5256660 Synthetic buffer composition for clinical use  
Methods of administering aqueous synthetic buffer compositions of an N-substituted aminosulfonic acid and a sodium salt of a different substituted aminosulfonic acid suitable to treat oligemic,...
5248680 Zwitterionic compounds and their n-halo derivatives for use in the treatment of clinical conditions  
Zwitterionic compounds selected from: taurine (2-aminoethanesulphonic acid), 2(N-morpholino)ethanesulphonic acid (MES), N-(2-acetamido)iminodiacetic acid (ADA), ...
5236922 Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives  
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH 2 , Y is H or a halogen atom, Z is H or a...
5223498 Phenylamidine and phenylguanidine derivatives and their use as antidiabetic agents  
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R 1 and R 2 are each aliphatic or cycloalkyl or NR 1 R 2 is an optionally substituted heterocyclic ring, R 3 is alkyl,...
5215992 Ethanobicyclic amine derivatives for CNS disorders  
Certain ethanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of...
5202346 Piperidinyl and piperazinyl derivatives  
Compounds of the formula: ##STR1## in which R 1 is alkylsulfonamido of 1 to 6 carbon atoms, arylsulfonamido of 6 to 10 carbon atoms, --NO 2 ,--CN, 1-imidazolyl or 1,2,4-triazol-1-yl; Y is...
5190946 Methods and compounds  
Compounds of formula ##STR1## wherein R and R 3 , which may be the same or different, each is hydrogen, an alkyl group containing 1 to 5 carbon atoms, or an optionally substituted aryl or aralkyl...
5182284 Piperazine compounds, processes for preparation thereof and medical uses thereof  
Disclosed are a piperazine compound of the formula below or a pharmaceutically acceptable salt thereof, medical uses thereof, and processes for preparing the same: ##STR1## wherein each of R and R'...
5171753 Derivatives of 2-amino-1-phenylethanol having antiulcer activity  
Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted...
5166218 Phenoxypropanolamines and pharmaceutical compositions thereof  
Tertiary and secondary amines of the formulas ##STR1## and ##STR2## wherein n is the integer 1 or 2, R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl, X 1 is phenoxymethyl optionally...
5153226 Acat inhibitors for treating hypocholesterolemia  
The present invention are novel amino acid amide compounds of the following general formula which inhibit the enzyme acylcoenzyme A:cholesterol acyltransferase: ##STR1## wherein R is phenyl or 1-...
5153198 Agent for treatment of disorders of the cerebro-neural transmission system  
A compound of the formula [II] or pharmaceutically acceptable salt thereof, ##STR1## wherein R 1 is hydrogen or fluorine; R 2 is hydrogen or fluorine; R 3 is hydrogen, lower alkyl, lower...
5141940 Fungicidal liquid formulations  
The invention provides new solvent concentrates of the fungicidally active substance triforine (N,N'-bis[1-formamido-2,2,2-trichloroethyl]-piperazine) characterized by good solubility and good...
5116851 Pharmaceutical composition and method for treating cardiovascular diseases using substituted anilides and sulfonamides  
A novel pharmaceutical composition and method is disclosed for the treatment of cardiovascular diseases, e.g. myocardial ischemia and/or arrhythmia. The method and composition include an effective...
5112866 Ethanesulfonamide derivatives  
The synthesis of novel ethanesulfonamide compounds is described. The novel ethanesulfonamide compounds have antisecretory activity and are used in the treatment of peptic ulcer disease. The...
5104872 N-(substituted benzyloxy) imine derivatives and method of use thereof  
Compound of the general formula (I), which is useful as an agricultural and horticultural fungicide, an agricultural and horticultural fungicidal composition containing said compound, use of said...
5075337 Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders  
Deuterated 2-alkylaminoacetamide compounds are described having the alpha carbon of the alkyl side chain of the compounds substituted by one or two deuterium atoms. These compounds have...
5064863 Phenoxypropanolamines and pharmaceutical use  
Tertiary and secondary amines of the formulas ##STR1## wherein n is the integer 1 or 2, p0 R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl, X 1 is phenoxymethyl optionally...
5051424 Substituted aromatic compounds having an action on the central nervous system  
This invention relates to dopamine uptake-inhibiting compounds of the general formula I: ##STR1## wherein R 1 and R 2 independently are hydrogen, NO 2 , OH, halogen, C 1 -C 4 alkyl, C 1 -C 4 ...
Matches 251 - 300 out of 493 < 1 2 3 4 5 6 7 8 9 10 >