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8178539 Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods  
Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenal ene-9-amines, pharmaceutical compositions containing the compounds or salts thereof, intermediates, methods of making the...
8173157 Pharmaceutical composition comprising phenylamidine derivative and method of using the pharmaceutical composition in combination with antifungal agent  
A pharmaceutical composition comprising a phenylamidine derivative or a salt thereof, represented by a general formula, wherein R1 and R2 may be same or different, and represent an optionally...
8168638 Pyrazinecarboxamide derivatives and plant disease controlling agents containing the same  
The present invention provides the compounds represented by the general formula (I): [wherein X is a halogen atom or an (C1-C3)alkyl group which may be substituted with a halogen atom(s); Y is a...
8158631 Heterocyclic antiviral compounds  
Compounds having the formula I wherein R1, R2, R3, R4, and R5 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV...
8158630 Application of 2,5 -dihydroxymethyl-3,6-dimethyl pyrazine and its derivates in pharmacy  
An application of 2,5-dihydroxymethyl-3,6-dimethyl pyrazine and its derivatives in the preparation of drugs for the treatment of, prevention of, and/or protection from heart failure wherein the...
8138189 Substituted benzene compounds as modulators of the glucocorticoid receptor  
The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds...
8114898 Compositions and methods for treating purpura  
Embodiments of the present invention are directed to compositions and methods for the treatment of purpura. Preferred compositions comprise an α adrenergic receptor agonist selected from selective ...
8110577 Histone deacetylase inhibitors  
The present invention provides histone deacetylase inhibitors of general formula (I), a process for the preparation of such compounds and uses of the compounds in medicine, especially in the...
8097625 Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression  
One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The...
8076341 Compounds and use thereof  
A compound of formula (I) wherein R1 is selected from H, F, Cl, Br, CF3, C1-C6 alkoxy and OH; R2 is selected from H and C1-C6 alkyl; n is 1-12; m is O or 1; Y is selected from CH2, NR3, (NR3R4)+X,...
8071594 Substituted diketopiperazines and their use as oxytocin antagonists  
Compounds of formula (1) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is 2-methyl-1,3-oxazol-4-yl and R4 and R5 together with the notrogen atom to which they are attached represents...
8067418 Tricyclic angiotensin II agonists  
There is provided compounds of formula I, wherein the dotted line, X1, X2, X3, A, Y1, Y2, Y3, Y4, Z1, Z2, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable salts...
8048884 Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists  
The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is —C(H)═ or —N═; m is 0, 1 or 2; R1 is optiona...
8044053 Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators  
The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the...
8030313 Controlled release sterile injectable aripiprazole formulation and method  
A controlled release sterile freeze-dried aripiprazole formulation is provided which is formed of aripiprazole of a desired mean particle size and a vehicle therefor, which upon constitution with...
7981894 Polymorphic forms of 1-′4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride  
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl) butyl]-4-(2-carbomyl-benzofuran-5-yl)-piperazine, crystaline modification of the...
7981436 Hydrogels for the controlled release of bioactive materials  
The present invention relates to the formation of hydrogels based on guanosine hydrazide derivatives in the presence of cations. The hydrogels can be used as a carrier/delivery system for...
7977332 Insecticidal N-(heteroarylalkyl)alkanediamine derivatives  
Certain noel N-(heteroarylalkyl)alkanediamine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein Ar, a, r, R, Ra, Rb,...
7968547 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
7964606 Therapeutic agents useful for treating pain  
The present invention discloses compounds of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Phenylene Compound”); compositions com...
7960384 Dipeptidyl peptidase inhibitors  
Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined...
7951830 Compounds effecting glucokinase  
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a...
7947684 1-aroyl-piperidinyl benzamidines  
This invention relates to compounds of formula which inhibit Factor Xa or tryptase, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of...
7947685 Pyrazine-2-carboxyamide derivatives  
The present invention is concerned with novel pyrazine 2-carboxyamide derivatives of formula (I) wherein R1, R2 and R3 are as defined in the specification. These compounds are useful for the...
7923446 Biaryl sulfonamides and methods for using same  
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
7851501 Aromatic nitrocatechol compounds and their use for modulating processes mediated by cell adhesion molecules  
Pharmaceutical compositions comprising at least one compound of e.g. the formulas (Ie) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents...
7851475 Substituted pyrrole-2, 5-diones as protein kinase C inhibitors  
A compound of formula I wherein R, Ra and Rb are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions...
7838520 Inhibitors of histone deacetylase  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
7829563 Aminoamides as orexin antagonists  
The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure...
7820663 Substituted enaminones, their derivatives and uses thereof  
The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of ...
7820671 Peptidomimetic protease inhibitors  
The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors;...
7812017 4-substituted indole and indoline compounds  
The present invention relates to novel compounds of formula (I): wherein m, n, R0, R1, R2, R3 and R4 are as described herein, to pharmaceutical compositions comprising the compounds, to processes...
7807680 Controlled release sterile injectable aripiprazole formulation and method  
A controlled release sterile freeze-dried aripiprazole formulation is provided which is formed of aripiprazole of a desired mean particle size and a vehicle therefor, which upon constitution with...
7807677 HIV protease inhibitors  
Compounds of the formula I: wherein R1, R2, X and N are as defined in the specification;E is N, CH;A′ and A″ are terminal groups as defined in the specification. The compounds have utility as HIV...
7803802 Substituted amide beta secretase inhibitors  
Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4 and X are as defined in the specification. Also disclosed are...
7799786 Therapeutic agents useful for treating pain  
A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amo...
7795302 Use of compositions for treating rosacea  
Rosacea is treated with a composition comprising an antimicrobial and at least one of an anti-inflammatory and a non-retinoid inhibitor of at least one of NF-KB, AP-1, MMPs, adhesion molecules,...
7780986 Method of preparing sustained-release preparations of quinolone antibiotics  
The present invention relates to an orally administrable preparation comprising a quinolone antibiotic which releases the active compound with a delay.
7732450 Antifungal ketoconazole composition for topical use  
A pharmaceutical composition suitable for topical application comprising ketoconazole in a solution which comprises: (i) 13 to 50 wt % water; (ii) 45 to 85 wt % of an alcohol having a boiling point...
7718668 Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives  
The invention relates to salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4-inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical...
7696191 Crystalline compound  
A novel crystalline form of 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-[(1-methyle thyl)oxy]-N-1H-pyrazol-3-ylbenzamide is described in the specification. This compound is a glucokinase (GLK...
7687067 2-pyridinylcycloalkylcarboxamide derivatives useful as fungicides  
A compound of general formula (I): A process for preparing this compound.An intermediate of general formula (II) for the preparation of a compound of general formula (I). A fungicidal composition...
7625949 Methods for treating retroviral infections  
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1...
7622471 Pyrazole derivatives having a pyridazine and pyridine functionality  
The present invention is directed to a strong platelet aggregation-inhibiting agent which does not inhibit COX-1 or COX-2. Further, the present invention provides compounds represented by formula...
7622472 Combination of Src kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases  
Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.
7612074 Diazabicyclic aryl derivatives as cholinergy ligands  
This invention relates to novel diazabicyclic aryl compounds of the formula wherein: R′ represents hydrogen or alkyl; A represents an aromatic monocyclic or bicyclic carbocyclic or heterocyclic; a...
7598248 Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use  
Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their...
7595318 Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids  
Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the...
7566716 Imidazopyrazines as Raf inhibitor compounds  
Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and...
7547701 Haloalkyl containing compounds as cysteine protease inhibitors  
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
Matches 1 - 50 out of 269 1 2 3 4 5 6 >