Patents in Class 514/252.060

Matches 1 - 50 out of 131

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Match	Document	Document Title
1	7625905	Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R 1 -R 3 and Ar are as defined herein are antagonists of chemokine CCR5...
2	7541354	Bicyclo-pyrazoles Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
3	7531531	Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
4	7511038	Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors New pyridazin-e-(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and...
5	7507734	Pyridazinone derivatives Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R 1 and R 2 are detailed in the description, as well as their physiologically acceptable...
6	7491722	Pyridazin-3(2H)-one derivatives Pyridazin-3(2H)-one derivatives of formula (I) are found to inhibit PDE-4. R 1 , R 2 and R 4 are organic radicals, R 3 is a cyclic group, and R 5 is an ester or an aryl or heteroaryl group.
7	7476673	Disubstituted chalcone oximes as selective agonists of RAR_γ retinoid receptors Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases...
8	7470689	4-benzimidazol-2-ylpyridazin-3-one derivatives Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R 1 and R 2 are detailed in the description, and the physiologically tolerated salts...
9	7465811	Indoline compounds Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
10	7462613	Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C 1 -C 10 -alkyl, aryl,...
11	7407950	N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands The invention concerns compounds of general formula (I), wherein n, X 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and W are as defined herein. Said compounds are ligands of the TRPV 1 ...
12	7399765	Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar 1 —Ar 2 (I) wherein Z is a diazabicyclic...
13	7285551	Fused-ring compounds and use thereof as drugs The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
14	7282498	Substituted fused pyrroleoximes and fused pyrazoleoximes Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
15	7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
16	7148249	Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R 1 to R 5 and X are defined as in claim 1, the tautomers, the diastereomers, the...
17	7081458	Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are...
18	6974815	Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K is O or S; Q is —C(═O)— or optionally substituted C...
19	6903112	Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
20	6897229	Synergistic combination comprising roflumilast and a PDE-3 inhibitor The PDE 4 inhibitor N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-difluorome thoxy benzamide, a pharmacologically tolerable salt or N-oxide thereof, in combination with a PDE 3 inhibitor is...
21	6867206	6-carboxyphenyldihydropyridazinone derivatives and use thereof The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R 1 , R 2 , R 3 , A, D, G, and E are as defined in the specification and claims, a...
22	6861430	β-carboline derivatives and its pharmaceutical use against depression and anxiety The invention provides compounds of formula (I) wherein R1 to R5 are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals.
23	6846818	Selective inhibitors of cyclooxygenase-2 The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The...
24	6762182	Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors A method of altering specificity of cyclooxygenase-inhibiting compounds that have a COOH moiety by changing the various COOH containing compounds, such as indomethacin, into ester derivatives or...
25	6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
26	6680316	Pyridazin-3-one derivatives and medicines containing the same Objects of the invention are to provide compounds having excellent activity against interleukin-1β production and also medicines comprising them as effective ingredients. Pyridazin-3-one...
27	6656941	Aryl substituted tetrahydroindazoles Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables R 1 , R 2 , R 3 , n, and Ar are defined herein. These compounds are highly...
28	6649613	Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R 1 , 2 and R 3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin...
29	6620834	Medicinal compositions for treating colorectal cancer Medicinal compositions for colorectal cancer to be administered to the large intestine by taking advantage of preparations disintegrating in the large intestine, characterized by containing a...
30	6562817	Tricyclic compound The present invention provides a compound of the formula (I): wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5-...
31	6555540	Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
32	6538010	Compounds and methods for promoting smoking cessation Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
33	6521656	Remedies for male sterility Efficacious remedies for male sterility which are in the form of preparations containing as the active ingredient an adenosine A 1 antagonist.
34	6511968	Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis,...
35	6492366	Cyano-indole serotonin-reuptake inhibitor compound A compound selected from those of formula (I): wherein: R 1 and R 2 each independently represent hydrogen or, alkyl, T 1 and T 2 each independently represent alkylene, G represents a...
36	6472416	Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors The present invention encompasses novel sulfonylphenylpyrazole compounds useful in the treatment of cyclooxygenase-2 mediated diseases.
37	6384070	Indole derivatives useful as endothelin receptor antagonists Compounds of formula (I), and their pharmaceutically acceptable derivatives, wherein R 1 and R 2 are optional substituents and independently represent C 1-6 alkyl, C 2-6 alkenyl, optionally...
38	6358978	Substituted benzimidazoles Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.
39	6355640	Pyrazolopyridine adenosine antagonists The present invention relates to a novel pyrazolopyridine compound of the following formula: wherein R 1 is aryl, and R 2 is cyclo(lower)alkyl which may have one or more suitable...
40	6329418	Substituted pyrrolidine hydroxamate metalloprotease inhibitors The invention provides compounds which are potent inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the...
41	6306890	Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors A compound of the formula ##STR1## where: n, and X are as defined in the specification, and the compound possesses selectivity for inhibition of cyclooxygenase-2.
42	6297243	Methods of treating hot flashes, estrogen deficiencies and deferring menopause by the administration of a luteinizing hormone antagonist A pharmaceutical composition comprising a LH antagonist or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier is useful for deferring the onset of menopause.
43	6277877	Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors Compounds of Formula (I) ##STR1## wherein R 6 is carboxy, (C 1 -C 8 )alkoxycarbonyl, benzyloxycarbonyl, C(O)NR 8 R 9 or C(O)R 12 as glycogen phosphorylase inhibitors, pharmaceutical...
44	6245797	Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease The instant invention provides a drug combination comprised of an HMG-CoA reductase inhibitor in combination with a COX-2 inhibitor, which is useful for treating, preventing, and/or reducing the...
45	6225324	Antidepressant heterocyclic compounds Compounds of formula I are useful antidepressant agents ##STR1## demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or...
46	6177442	Bicyclic amine derivatives The invention provides a compound of formula (I): ##STR1## wherein A represents a bidentate group of formula --CH 2 --X--CH 2 -- (wherein X is methylene, sulfur or oxygen), X'CCY or X'WC--CYZ...
47	6174883	3-substituted-2-oxindoles derivatives This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the phamaceutically-accepted salts thereof which are inhibitors of prostaglandin H 2 synthase,...
48	6166041	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH 2 ...
49	6156753	Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction A method is provided for treating erectile dysfunction, e.g., vasculogenic erectile dysfunction such as vasculogenic impotence. The method involves the administration of a Type III...
50	6100268	Vasoconstrictive dihydrobenzopyran derivatives The present invention is concerned with compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R 1 is...

Matches 1 - 50 out of 131

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