Patents in Class 514/252.05

Matches 1 - 50 out of 252

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Match	Document	Document Title
1	8183241	2-oxo-1-pyrrolidine derivatives The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
2	8178538	Pyridazinones The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts...
3	8163793	Proline derivatives The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
4	8153634	Carbinol derivatives having cyclic linker [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; ...
5	8124628	Diaryl substituted alkanes The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic,...
6	8084442	N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or...
7	8080551	HIV inhibiting pyrimidines derivatives HIV replication inhibitors having formula (I) defined herein are disclosed. Pharmaceutical compositions containing the HIV replication inhibitors; the use of the HIV replication inhibitors in the...
8	8076331	Substituted pyridazine derivatives The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.
9	8076334	Prodrugs of thyroid hormone analogs Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
10	8044053	Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the...
11	8022073	Substituted pyridazine compounds and fungicidal uses thereof A pyridazine compound of the formula: has an excellent plant disease controlling effect.
12	8017610	Phenylpyrrole derivative The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or...
13	8008301	Histamine H3 receptor agents, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine—H3 receptor antagonist or inverse agonist activity, as well as m...
14	8003649	Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 The invention concerns bicyclic compounds of Formula I wherein the integers X1, X2, X3, Ring A, R4, R5 and m are as defined in the description. The present invention also relates to processes for...
15	8003650	Hydrazide compound and harmful arthropod-controlling agent containing the same Disclosed is a hydrazine compound represented by the formula (1) below, which has an excellent control activity against a harmful arthropod. (1) (In the formula, R1, R5, R6 and R7 represent a...
16	7964204	Isoxazolines for controlling invertebrate pests Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof, Formula (1): wherein A1, A2, A3, A4, A5 and A6 are independently, selected from the...
17	7964620	Imidazole derivatives The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. The invention also...
18	7960380	Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X...
19	7943619	Isoxazolo-pyridazine derivatives The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for...
20	7915250	Azetidines as MEK inhibitors for the treatment of proliferative diseases Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such...
21	7906513	Hydrazide-containing hepatitis C serine protease inhibitors The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine...
22	7897627	Heteroaryl derivatives as orexin receptor antagonists The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or...
23	7875615	Substituted triazole derivatives as oxytocin antagonists The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions...
24	7799787	Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds...
25	7790724	c-fms kinase inhibitors The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically...
26	7772235	mGluR5 modulators The present invention is directed to compounds of formula I: Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the...
27	7759349	Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives Novel imidazo[1,2-b]pyridazine compounds useful for controlling parasites in animals and methods of treatment of parasite infestation in animals using the compounds are disclosed.
28	7754717	Bis-aryl amide compounds and methods of use The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one...
29	7732445	Myosin light chain kinase inhibitor compounds, compostions and related methods of use Pyridazinyl compounds, compositions and related methods of use.
30	7723333	Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X...
31	7713975	3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically...
32	7687508	Cyclic derivatives as modulators of chemokine receptor activity This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same,...
33	7678796	MGluR5 modulators I The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
34	7666871	Oxazole derivatives as histamine H3 receptor agents, preparation and therapeutic uses The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity,...
35	7579350	Scaffolds for α-helix mimicry Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated...
36	7563790	Pyridazine derivatives Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid arthritis,...
37	7544684	Hydrazono-malonitriles Hydrazono-malonitrile derivatives of the formula (I) in which R1, R2, R3, R3′ and R4 have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for the t...
38	7514428	Pesticidal 1-aryl-3-amidoxime-pyrazole derivatives 1-Arylpyrazole-3-substituted-amidoxime derivatives of formula (Ia) or (Ib): or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof,...
39	7511042	Triazole compounds Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine...
40	7491722	Pyridazin-3(2H)-one derivatives Pyridazin-3(2H)-one derivatives of formula (I) are found to inhibit PDE-4. R1, R2 and R4 are organic radicals, R3 is a cyclic group, and R5 is an ester or an aryl or heteroaryl group.
41	7479492	Use combined 5-HT1A agonists and selective serotonin reuptake inhibitors The present invention relates to the use of compounds being combined selective serotonin (5-HT) reuptake inhibitors (SSRIs) and 5-HT1A receptor agonists, in particular of...
42	7470687	Aryl oximes Aryl oxime derivatives of the formula (I), in which R1, R2, R3, X and B are as defined in Claim 1, act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis,...
43	7462613	Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl,...
44	7452906	Pyridine derivatives as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
45	7452882	Thyroid hormone analogs Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
46	7452885	Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and ...
47	7432254	Method for treating glaucoma IC Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising...
48	7429581	Pyrazole-derivatives as factor Xa inhibitors The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is a pharmacologically active...
49	7399765	Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or s...
50	7361654	Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity ...

Matches 1 - 50 out of 252

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