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7381725 |
Pyridazine derivatives as ligands for GABA receptors
A class of pyridazine derivatives, substituted in the 4-position by an optionally substituted heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity...
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7348327 |
Compounds
The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
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7320977 |
Substituted 2-phenyl-3(2h)-pyridazinones
The invention relates to substituted 2-Phenyl-3(2H)-Pyridazinones, to a method for the production thereof, and to their use as medicaments for the prophylaxis and/or treatment of diseases in humans...
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7294627 |
Chemical compounds
Compounds of formula (I)
in which R 1 , R 2 , R 3 and R 4 , have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
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7294625 |
Pyrazole compounds
The present invention relates to pyrazole compounds represented by the formula (I):
wherein R 1 represents phenyl which may be substituted, R 2 represents H, halogen, alkyl, alkoxy,...
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7259157 |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I):
or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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7256192 |
Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof
The present invention relates to an aromatic diamide derivative represented by the general formula (I):
[A 1 is optionally substituted (C 1 -C 8 )alkylene group, (C 3 -C 8 )alkenylene...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214678 |
Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
According to the invention there is provided a compound the formula I;
wherein A, X, B, R 1 , R 2 , R 3 and R 4 are as defined in the specification.
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7211577 |
Water-soluble phenylpyridazine derivative and medicine containing the same
A phenylpyridazine derivative represented by the formula (1):
Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine...
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7205301 |
Microbiocidal N-phenyl-n-[4-(4-pyridyl)-2-pyrimidin-2-yl]-amine derivatives
Fungicidal compounds of Formula (I) wherein m is 0, 1, 2 or 3; n and p are independently of each other 0 or 1; R 1 is halogen, optionally substituted alkyl, optionally substituted alkoxy,...
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7183283 |
Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds
The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C 1-4 -alkyl; one of X and Y stands for hydrogen and the other...
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7176204 |
Substituted carboxylic acid derivatives
Novel substituted carboxylic acid derivatives which bind as ligands to human peroxisome proliferator activated receptor (PPAR) to activate the receptor and thereby exhibit potent effects of...
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7166604 |
Antiviral agents
This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the...
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7135471 |
Aryl oximes
Aryl oxime derivatives of the formula (I), in which R 1 , R 2 , R 3 , X and B are as defined in claim 1 , act as phosphodiesterase IV inhibitors and can be employed for the treatment of...
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7129243 |
Peptide compounds
The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto...
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7129241 |
Pyridazine derivatives
Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis,...
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7122546 |
Imidazol-1-ylmethyl pyridazine derivatives
The invention provides imidazol-1-ylmethyl pyridazine derivatives of the formula:
that bind to GABA A receptors. In the above formula, R 1 , R 2 R 3 , R 4 , R 5 , R 6 and Ar are defined...
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7098211 |
Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising...
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7098210 |
2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient
The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel...
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7081468 |
Ortho-substituted anthranilic acid amides and their use as medicaments
Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described.
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6903101 |
Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
Substituted and Fused pyridazines having angiogenesis inhibiting activity and the generalized structural formula
wherein the ring containing A, B, D, E, and L is a nitrogen-containing...
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6894041 |
Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6869945 |
Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6867206 |
6-carboxyphenyldihydropyridazinone derivatives and use thereof
The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula
wherein R 1 , R 2 , R 3 , A, D, G, and E are as defined in the specification and claims, a...
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6831083 |
Pyrazoline derivative or tetrahydropyridazine derivative and medicinal use thereof
Using a compound selected from compounds represented by the following formula (1) (which include 3-phenyl-2-pyrazoline derivatives and 3-phenyl-tetrahydropyridazine derivatives) and...
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6800628 |
N-substituted 4-((-4′-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties
This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R 1 is C 1-6...
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6787546 |
Heterocycle derivatives and drugs
The object of the invention is to provide an excellent compound as a drug. The invention relates to a heterocyclic compound shown by the following formula: A—B—D—E [ 1] wherein A is...
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6777412 |
Fungicides
The invention provides fungicidal compounds of formula (I) or stereoisomers thereof: wherein X is CH 2 O; A is hydrogen; E is hydrogen; q is 1; any two of K, L and M are nitrogen and the other...
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6759414 |
Aromatic amides
This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa,...
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6730672 |
Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
The invention concerns compounds of formula (I) wherein each of G 1 , G 2 and G 3 is CH or N; m is 1 or 2; R 1 includes hydrogen, halogeno and (1-4C)alkyl; M 1 is a group of the formula: NR...
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6696437 |
Heterocyclically substituted benzimidazoles, the production and application thereof
The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.
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6689780 |
Heteroroaromatic amides as inhibitor of factor Xa
This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa,...
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6680316 |
Pyridazin-3-one derivatives and medicines containing the same
Objects of the invention are to provide compounds having excellent activity against interleukin-1β production and also medicines comprising them as effective ingredients. Pyridazin-3-one...
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6677354 |
Piperdines for use as orexin receptor antagonists
Disclosed are compounds of formula (I): wherein: Y represents a group (CH 2 ) n , wherein n represents 0, 1 or 2; R 1 is phenyl, naphthyl, a mono or bicyclic heteroaryl group containing up to 3...
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6676932 |
Ultraviolet absorbent, photostabilizer, ultraviolet ray-absorbing composition, photostabilized composition and external preparation for skin
Providing an ultraviolet absorbent or photostabilizer with excellent absorption over a wide ultraviolet wavelength range and great stability and a high safety profile, as well as an...
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6664256 |
Phenylpyridazine compounds and medicines containing the same
Phenylpyridazine compounds represented by the following formula (I): are provided, wherein R 1 , R 2 , R 3 , R 4 , and n are as defined herein having excellent inhibitory activity against...
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6624166 |
Pyridazines as interleukin-1β converting enzyme inhibitors
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R 1 is a halogen, or an oxygen linked leaving group including an aromatic ether, an alkyl...
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6617325 |
Biphenyl derivatives, production thereof and uses as medicines
The present invention relates to biphenyl derivatives of general formula wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically...
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6602889 |
5-heteroaryl substituted indoles
The present invention relates to compounds having general formula (I) as defined herein, or a pharmaceutically acceptable acid addition salt thereof. The compounds are selective α 1 -adrenoceptor...
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6602872 |
Substituted pyridazines having cytokine inhibitory activity
There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
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6602871 |
Thrombin or factor Xa inhibitors
This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the...
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6593346 |
N-cyclopentyl modulators of chemokine receptor activity
The present invention is directed to compounds of the formula I: (wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , X, n, x and y are defined herein) which are useful as modulators of chemokine...
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6569860 |
Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists
This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I): wherein G 2 is a heteroaryl group containing one or two nitrogen atoms...
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6562824 |
Dihydropyridine soft drugs, and related compositions and methods
This invention relates to novel dihydropyridine soft drugs of the formula ΦOOR 1 , where Φ is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with...
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6548520 |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
The present invention is related to novel 2-alkyl substituted imidazoles of formula (I) useful for the treatment of CSBP kinase mediated diseases.
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6514974 |
Pyrido-, pyrimido-, pyridazo- and pyrazo- pyridazines having angiogenesis inhibiting activity
The invention relates to compounds of formula I, wherein r is 0 to 2, n is 0 to 2; m is 0 to 4; R 1 and R 2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I* ...
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6498161 |
Pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are defined herein) which are useful as modulators of chemokine...
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6479494 |
Arylalkanoyl pyridazines
Arylalkanoylpyridazine derivatives of the formula I and the physiologically acceptable salts thereof in which R 1 , R 2 , R 3 , R 4 , Q and B have the meanings given in Claim 1 act as...
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