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7378419 |
9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives
The invention relates to compounds of formula (I), wherein R 1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl,...
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7371755 |
Antiviral agents
This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.
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7365066 |
Pyrazolopyridine derivatives as pharmaceutical agents
Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of...
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7348335 |
Compositions useful as inhibitors of JAK and other protein kinases
The present invention provides a compound of formula I:
or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the...
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7332494 |
Method for treating allergies using substituted pyrazoles
A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
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7332492 |
Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
Compounds of formula (I):
wherein:
X is a group of formula (B):
and R 1 , R 2 , R 4 , n, x, y and z are as defined within are described.
Processes for their preparation and...
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7314877 |
Benzofuran derivative
The present invention is directed to a compound represented by formula (1):
(wherein R 1 represents an alkyl group which may have a substituent or an alkenyl group which may have a...
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7312227 |
Compositions useful as inhibitors of JAK and other protein kinases
The present invention provides a compound of formula I:
or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the...
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7279480 |
Hexahydropyridazine-3-carboxylic acid hydrazide and hydrazone derivatives, combinatorial libraries containing same, pharmaceutical compositions containing same and methods of preparation
The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I)
as inhibitors of proteases and kinases, and methods of using said...
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7253188 |
Aminobenzamide derivative
This invention relates to a novel compound represented by the formula (I):
or a pharmaceutically acceptable salt thereof,
wherein R 1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p...
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7247631 |
Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
Methods for treating treatment-naive as well as treatment-experienced adult and pediatric patients having HIV-1 infections as well as patients co-infected with HIV-1 and HCV involving administering...
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7235560 |
Pyrimidine derivative as selective COX-2 inhibitors
The invention provides the compounds of formula (I)
or a pharmaceutically acceptable salt thereof.
Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the...
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7223758 |
Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation
The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined
herein, pharmaceutical composition thereof, process for its preparation, and its...
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7223728 |
Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat metabolic instability associated with non-insulin dependent diabetes
Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus,...
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7211578 |
Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity
This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the...
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7202247 |
1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7148233 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as hypertrophy are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7144892 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as myocardial infarction are described. The methods are directed to concurrently administering a compound such as...
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7132430 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as arrhythmia are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7125889 |
Treating of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as blood clots are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7115626 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as ischemia, ischemia reperfusion injuries, and myocardial ischemia, are described. The methods are directed to concurrently...
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7115625 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such congestive heart failure are described. The methods are directed to concurrently administering a compound such as...
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7109161 |
Preserved pharmaceutical formulations
The present invention is directed to the use of benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to provide anti-microbial activity in pharmaceutical...
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7078403 |
Antiviral agents
Disclosed herein are compounds of formula II:
wherein Alk, Z, X 1 , X 2 , R 1 , —R 10 and R 11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as...
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7045530 |
Spirocyclic quinuclidinic ether derivatives
Compounds of formula (I)
wherein n1 is 0, 1, or 2; n2 is 0, 1, or 2; X is a bond, O, S, or NR 1 ; and Ar 1 is a 5-membered aromatic ring, 6-membered aromatic ring, or a fused...
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7034022 |
Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation
The present invention discloses and claims compounds of formula (I)
as inhibitors of proteases and kinases, method using said compounds of formula (I) for the prevention or treatment of certain...
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7030128 |
Imidazo-pyrimidine derivatives as ligands for GABA receptors
A class of imidazo[1,2-α]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABA A ...
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7026270 |
Biocidal compounds and their preparation
This invention concerns new biocidal compounds of formula (I) wherein R is H or CH 3 . Of particular interest are two isomers that are named malayamycin A and desmethylmalayamycin A. These isomers,...
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7019006 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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7015225 |
Anti-cancer agents and methods
Derivatives of retinamide are potent and selective apoptosis-inducing agents. These compounds exhibit antitumor properties and as such can be used in the treatment of cancer and other...
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7012077 |
Substituted cyclohexane derivatives
The present invention relates to compounds of formula (I)
wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , U, V, m, n and o are as defined in the specification, and pharmaceutically acceptable salts...
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6943170 |
N-cycloalkylglycines as HIV protease inhibitors
This invention relates generally to N-cycloalkylglycines of the Formula (I):
or a stereoisomeric form, a mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, which...
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6930110 |
Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R 1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or...
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6927217 |
HIV protease inhibitors
The present invention relates to novel dihydropyrones of Formula I
wherein X is NH or NR 8 , which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in...
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6878709 |
3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
Disclosed are compounds of the formula (I)
or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and...
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6875770 |
Indole derivative having heterocycle and mono- or diazaindole derivative
There is provided a compound represented by the general formula (1):
wherein Het represents an optional substituted heterocylic group A 1 and A 2 each independently represent —CH═, etc.;...
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6872722 |
Therapies for tissue damage resulting from ischemia
This invention relates to therapeutic methods for treatment or prevention of tissue damage resulting from ischemia in mammals.
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6812231 |
Benzamidine derivative
Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated...
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6803370 |
Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4
Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such...
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6797709 |
Aromatic nitrogen-containing 6-membered cyclic compounds
An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R 1 is a substituted or...
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6794378 |
Heterocyclic compounds and medical use thereof
The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an...
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6784198 |
Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents
2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R 1 , R 2 and R 3 are defined herein, or pharmaceutically acceptable salts thereof are useful as, for example, the...
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6777412 |
Fungicides
The invention provides fungicidal compounds of formula (I) or stereoisomers thereof: wherein X is CH 2 O; A is hydrogen; E is hydrogen; q is 1; any two of K, L and M are nitrogen and the other...
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6737082 |
Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
It comprises a compound having antifungal activity as active principle, an inert core and a coating including said active principle, and is characterized in that said inert core has a particle size...
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6730672 |
Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
The invention concerns compounds of formula (I) wherein each of G 1 , G 2 and G 3 is CH or N; m is 1 or 2; R 1 includes hydrogen, halogeno and (1-4C)alkyl; M 1 is a group of the formula: NR...
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6710046 |
Pharmaceutical composition for modulating immunity
Disclosed is a pharmaceutical composition for modulating immunity, which comprises a benzimidazole, represented by the following general formula (I), a 3H tautomer, an optically active enantiomer...
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6706745 |
Biphenylamidine derivatives
The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically...
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6696446 |
Benzoylpyridazines, their preparation and use
Benzoyl derivatives of formula (I) and their physiologically acceptable salts and solvates, in which R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the meanings indicated, inhibit phosphodiesterase...
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6693121 |
Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
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6683108 |
Agonists of hedgehog signaling pathways and uses related thereto
The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small...
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