Matches 301 - 350 out of 572 < 1 2 3 4 5 6 7 8 9 10 11 12 >
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5622950 Pyrrolo-pyridine derivatives  
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a...
5618815 1,9-bridged thiazolo[3,2-a]quinoline derivatives  
The present invention relates to 1,9-bridged thiazolo[3,2-a]quinoline derivatives of the general formula (I) ##STR1## in which the substituents Z, X, R 1 have the meaning given in the description,...
5616586 Tricyclic quinoxalinediones  
Tricyclic quinoxalinediones of the formula: ##STR1## wherein X is alkyl, halogen, cyano, trifluoromethyl, nitro, hydroxy, amino, etc.; R 1 is H, etc.; R 2 is H, alkyl, cycloalkyl, alkenyl,...
5604224 Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5599809 Method for improving reproductive efficiency in farm animals  
Oxytocin receptor antagonists of the formula ##STR1## wherein R 12 is hydrogen, alkoxycarbonyl or unsubstituted of substituted alkyl; R 13 is hydrogen, alkoxyl, aralkoxyl, alkoxycarbonyl,...
5599812 Tricyclic pyrrolopyrazine 5-HT.sub.3 -active compounds  
The present invention relates to a compound selected from these of formula (I): ##STR1## in which A and R 1 are as defined in the description, and medicinal product containing the same which is...
5597823 Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists  
The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic...
5589476 Imidazol-4-ylpiperidine derivatives, their preparation and their application in therapeutics  
A compound of formula (I): ##STR1## in which R 1 represents a hydrogen atom or a straight or branched (C 1 -C 4 )alkyl group; and A represents a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl...
5585347 Methods for the determination and adjustment of prolactin daily rhythms  
Disclosed are methods for detecting abnormalities in prolactin daily rhythms. The methods involve comparing a prolactin profile of a vertebrate (including a human) subject being tested that has...
5569658 Tricyclic derivatives  
The invention concerns tricyclic derivatives of the formula I ##STR1## wherein R 1 and R 2 together form an optionally substituted group of the formula --NCH--NH--, --NCH--O--,...
5569655 Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5559106 Heterocyclic compounds, their use and preparation  
Quinoxaline compounds of the general formula ##STR1## wherein R 1 is COX', POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R 6 , R 7 , R 8 ...
5550107 Combination therapy for the treatment of estrogen-sensitive disease  
A method of treatment of breast and endometrial cancer in susceptible warm-blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH...
5538972 Imidazoloquinoxalinones for the treatment of central nervous disorders  
The use of imidazoloquinoxalinones for the production of drugs for controlling central nervous disorders is described. The imidazoloquinoxalinones have the formula ##STR1## in which R 1 , R 2 and...
5538971 Benzoquinoxalines, pharmaceutical compositions containing them and their use in treating schizophrenia  
6-hydroxy or 6-alkoxy-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoxalines bearing in position 4 an optionally substituted phenyl group may be used in the treatment of schizophrenia, drug abuse or...
5536715 Combinations of anthelmintically active agents  
Pharmaceutical compositions comprising a compound of formula (I) and at least one other anthelmintically active compound, being an avermectin or a milbemycin, are useful in the treatment of...
5536660 Streptomyces viridodiastaticus subsp. "Littus" NRRL-21082N capable of producing antibiotics  
This invention relates to antibiotics 31F508α 1 , 31F508α 2 , 31F508β 1 and 31F508β 2 , produced by the microorganism Streptomyces viridodiastaticus subsp. "littus" NRRL-2108211. The...
5532236 [1,2,4]triazolo[4,3-a]quinoxaline compounds  
The present invention relates to [1,2,4]triazolo[4,3-a quinoxaline derivatives of formula I ##STR1## wherein one of R 1 and R 2 is a 5- or 6-membered nitrogen-containing heterocyclic ring which...
5521183 Use of 5-HT ligands as anti-pruritic agents  
The present invention is based on the finding that 5-HT receptor ligands are useful in treating experimental models of clinically encountered pruritus (itch). A 5-HT ligand as used in this...
5512564 Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them  
The present invention concerns thiazolo- 2,3-a!pyrrole and oxazolo- 1,2-a!pyrrole derivatives of formula I ##STR1## in which HET represents a heterocyclic ring with 3-7 ring atoms which can be...
5504085 Triazolo quinoxalines and their preparation and use  
Quinoxaline compounds represented by formulas I or II, ##STR1## wherein R 1 and R 2 are independently hydrogen, C 1 -6 -alkyl, halogen, NO 2 , NH 2 , CN, CF 3 , SO 2 NR 4 R 5 wherein R 4 and...
5502055 Treatment of endotoxic shock with putrescine  
The present invention provides a method for protecting a living subject from endotoxic shock. The method involves administering to the subject a pharmaceutical composition including an effective...
5489590 Method of treating with therapeutic composition comprising photoactive compound  
A therapeutic composition derived from a pre-activated photoactive compound and a conveyor for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The...
5484717 Antibiotic 31F508α.sub.1, 31F508α.sub.2, 31F508β.sub.1, 31F508β.sub.2  
This invention relates to antibiotic 31F508α 1 , 31F508α 2 , 31F508β 1 and 31F508β 2 , derived from the microorganism Streptomyces viridodiastaticus subsp. "littus" which are useful as an...
5478823 Composition for suppressing infiltration of eosinophils  
An agent for suppressing infiltration of eosinophils comprising as an effective ingredient a tricyclic triazolo derivative, which strongly suppresses infiltration of eosinophils into inflammatory...
5476851 Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase  
This invention relates to pyrazolo[3,4-g]quinoxaline compounds exhibiting protein tyrosine kinase inhibition activity of the formula: ##STR1## where: ------ may be a double bond; R, R 2 , R 3 ...
5470846 Treatment of neurological and mental disorders  
A method of treating neurological and mental disorders which are associated with and/or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in...
5468748 9H-indeno[1,2-b]pyrazine derivatives  
The present invention relates to 9H-indeno[1,2-b]pyrazin-3(4H)-ones and 9H-indeno[1,2-b]pyrazine-2,3(1H,4H)-diones or tautomeric forms thereof which are useful in treating neurological and...
5468747 Fungicidal compositions and methods of use employing pyrimidine derivatives  
Compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CE; X and Y are independently hydrogen, halogen, C 1 -4 alkyl, C 3 -6 cycloalkyl, C 2 -4...
5462963 Chelator compositions comprising α-diamine compounds  
The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising...
5459141 Compounds 31668P and 31668U, a process for their production and their use  
Compounds 31668P and 31668U, a process for their production and their use. Compound 31668P and compound 31668U with the formulae ##STR1## have an antibiotic and an antitumor action.
5441956 Hydroisoquinoline derivatives  
5441955 Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof  
Methods, compounds and compositions are provided form inhibiting the growth of pathogenic mycobacteria in vitro and of treatment of pathogenic mycobacterial infections in vivo using...
5438050 Indolocarbazole derivatives, processes for their preparation and compositions containing them  
New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the...
5436240 Heterocyclic amines having central nervous system activity  
Tricyclic nitrogen containing compounds, having central nervous system activity of the following structural formula: ##STR1## and pharmaceutically acceptable salts thereof wherein R 1 , R 2 , and R...
5433954 Method and composition for treating psoriasis, seborrheic dermatitis and eczema  
Psoriasis, seborrheic dermatitis and eczema are treated by oral administration of inorganic nickel compound(s), with or without inorganic bromide(s). In an especially preferred embodiment, the...
5426108 Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2  
This invention relates to antibiotic 31F508α 1 of the formula ##STR1## 31F508α 2 , 31F508β 1 and 31F508β 2 , derived from the microorganism Streptomyces viridodiastaticus subsp. "littus"...
5405847 4,5-dihydro-4-oxo-pyrrolo[1,2-a]quinoxalinones and corresponding aza analogs and a process for their preparation  
Novel compounds of the formula ##STR1## where the phenyl ring can also contain a nitrogen atom instead of a CH group, R 1 is C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy,...
5393756 5H-[1,2]benzisothiazolo[2,3-a]quinoline-5-ones and analogs as antiinflammatory agents  
The present invention relates to 5H-[1,2]benzisothiazolo[2,3-a]quinoline-5-ones, pharmaceutical compositions thereof and to methods of using these compounds for the treatment of inflammatory...
5356890 S-nitroso derivatives of ace inhibitors and the use thereof  
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically...
5352680 Delta opioid receptor antagonists to block opioid agonist tolerance and dependence  
A motion provided to alleviate the tolerance to, or dependence on, an opiate analgesic, by the administration of an effective amount of a selective delta opioid receptor antagonist to a human...
5350749 Pteridine derivatives  
4-substituted-pyrido[3,2-d]pyridmidine, -pyrido[4,3-d]pyrimidine, -pyrido[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, -pteridine, -pyrimido[4,5-d]pyrimidine, -pyrimido[4,5-c]pyridazine,...
5308842 Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds  
Conformationally constrained tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds and ring homologs thereof are topically effective carbonic anhydrase...
5308845 Quinoxaline compounds and their preparation and use  
Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R 1 is hydroxy; and R 5 and R 6 together form a fused phenyl, cyclohexyl or pyridyl ring, which is optionally...
5304559 Compositions containing a 4-quinolone derivative complexed with a divalent metal ion  
The present invention concerns a fluid pharmaceutical composition intended to be brought into contact with a physiological fluid, characterized in that it contains, as active principle, at least...
5300505 Stable salts of 5,10-methylenetetrahydrofolic acid  
Salts of 5,10-methylene-(6R)-, (6R,S)-, and (6S)-tetrahydrofolic acid with sulfuric acid or a sulfonic acid are stable in solid form and can be used as a constituent and/or as a starting material...
5292732 Pyrrolopyrazine derivatives  
The novel pyrrolopyrazines of the general formula ##STR1## wherein one of R 1 and R 2 signifies aryl and the other signifies hydrogen, lower alkyl or aryl or R 1 and R 2 together with the two...
5286727 N-methylepiamauromine, epiamauromine and cycloechinulin antiinsectan metabolites  
Diketopiperazine compounds designated N-methylepiamauromine, epiamauromine and cycloechinulin have been isolated from the sclerotia of the fungi Aspergillus ochraceus. The compounds are effective...
5283244 Fused pyrazine derivatives  
The present invention is a pyrazine derivative which has glutamate receptor antagonizing activity, represented by formula: ##STR1## wherein Z represents C or N, provided that two Zs are not N atoms...
5276028 Imidazoquinoxaline compounds  
The heterocyclic compounds having the general formula I ##STR1## wherein R 3 is ##STR2## wherein R' is H, C 1 -6 -alkyl or C 3 -7 -cycloalkyl; --B-- is --C(R")N-- or --NC(R")-- wherein R" is...
Matches 301 - 350 out of 572 < 1 2 3 4 5 6 7 8 9 10 11 12 >