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7183282 |
Substituted heterocycle fused γ-carbolines
The present invention is directed to compounds useful for treating addictive behavior and sleep disorders represented by structural Formula (I)
or pharmaceutically acceptable salt forms...
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7163939 |
Macrocyclic kinase inhibitors
Compounds having the formula
are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using...
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7160888 |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
This invention relates to compounds of the formula 1
wherein G, D, A, Z, Q, X, Y, R 1 , and R 4 through R 7 are defined as in the specification, processes for preparing the same and...
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7144882 |
Aryl fused azapolycyclic compounds
This invention is directed to compounds of the formula (I):
and their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of...
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7135480 |
Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
The present invention is directed to substituted 1-benzoyl-3-cyano-pyrrolo[1,2-α]quinolines and analogs thereof, represented by the general Formula I:
wherein R 1 –R 8 , L, Q, dash line and...
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7132419 |
Pharmaceutical compounds
A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I)
wherein each of R 1 to R 4 , which are the same or different, is selected from hydrogen, halogen, hydroxyl, C 1...
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7122549 |
Saframycins, analogues and uses thereof
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods...
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7098209 |
Pyrazino [1'2':1,6 ] pyrido [3, 4-b] indole-1,4-dione derivatives
Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent...
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7074792 |
1-(aminoalkyl)-3-sulfonylazaindoles as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7049308 |
C-nitroso compounds and use thereof
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon,...
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7034028 |
Treatment of inflammatory disorders
A method of treating an inflammatory disease or an autoimmune disease in a subject, comprises the administration of mefloquine.
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7034027 |
Fused heterocyclic derivatives as phosphodiesterase inhibitors
Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
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7008944 |
Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
Compounds of the formula:
are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety...
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7008941 |
Reverse-turn mimetics and methods relating thereto
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed:
...
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7001906 |
Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives
Compounds of formula (I):
wherein:
W 1 and W 2 , together with the carbon atoms to which they are bonded, represent a phenyl group or a pyridyl group, and at least one of the groups W 1...
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6987109 |
Solubilized topoisomerase poison agents
The invention provides compounds of formula I:
wherein
A, B, W, Y, Z, and R 1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The...
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6984641 |
Carboline derivatives as PDE5 inhibitors
Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
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6964964 |
Topoisomerase poison agents
The invention provides compounds of formula I:
wherein
A, B, W, Y, Z, R 1 , R 3 and R 4 have any of the meanings defined in the specification and their pharmaceutically acceptable...
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6962918 |
Hexahydropyrazino[1'2';1,6]pyrido[3,4-b]indole-1,4-diones for the treatment of cardiovascular disorders and erectile dysfunction
Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6960587 |
Condensed pyrazindione derivatives as PDE inhibitors
Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6953791 |
Dipeptide derivatives
This invention is directed to compounds of the formula
and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone...
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6946472 |
Polycyclic compounds exhibiting anti-tumor activities
This invention is concerned with novel polycyclic compounds of formula [I],
wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, R 1′ , R 2′ , R 3′ , R 4′ , R 5′ , R 6...
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6946464 |
Methods of treating and preventing a convulsive state
The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in...
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6943166 |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
The present invention relates to highly selective phosphodieterase (PDE) enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates...
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6933294 |
Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
Compounds having the formula (I),
and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R 1 , R 2 , and R 3 are hydrogen,...
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6933285 |
Flavin N-oxides: new anti-cancer agents and pathogen eradication agents
Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods...
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6930109 |
Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
Compounds of the formula
useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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6921771 |
Method of treating sexual disturbances
The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A)
in a dosage range where the sexually...
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6911475 |
Use of nicotine or its derivatives in a drug for treating neurological disease, in particular Parkinson's disease
The present invention concerns the use of nicotine or a derivative thereof for producing a drug for continuous or progressive administration of 0.2 mg to 5 mg per day per kilogram of body weight in...
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6911445 |
Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
Compounds of the formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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6903099 |
Condensed pyrazindione derivatives
Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6893652 |
Endoparasiticidal gel composition
A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture...
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6878711 |
Indole derivatives as PDE5-inhibitors
Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6875766 |
Use of riboflavin and flavin derivatives as chitinase inhibitors
The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.
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6872721 |
Derivatives of 2,3,6,7,12,12a-hexahydropyrazino-[1′,2′:1,6]pyrido[3,4b]-indole-1,4-dione
Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6869955 |
Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
Corticotropin releasing factor (CRF) antagonists of formula I:
and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
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6869956 |
Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors...
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6861422 |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
The present invention relates to new dihydropteridinones of general formula (I):
wherein the groups L and R 1 -R 5 have the meanings given in the claims and specification, the isomers...
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6858613 |
Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
The invention provides compounds of Formula I:
These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful...
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6858607 |
7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:
or pharmaceutically acceptable salts or prodrugs thereof, wherein:
...
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6855707 |
Method for the treatment of lipid and glucose metabolism disorders
Disclosed are methods for modifying or regulating at least one of glucose or lipid metabolism disorders which comprises administering to a human or vertebrate subject a D 1 dopamine agonist in...
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6852722 |
Compositions and methods for stimulating gastrointestinal mobility
The present invention is directed to methods for stimulating the motility of the gastrointestinal system in a patient which comprises administering a growth hormone secretagogue, a prodrug thereof...
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6844345 |
Piperazine derivatives
The present invention provides piperazine derivatives in accordance with formula (I)
as well as salts, hydrates and esters thereof. The substituent designations are as provided in the...
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6825197 |
Cyclic GMP-specific phosphodiesterase inhibitors
Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6821975 |
Beta-carboline drug products
A compound of structural formula (I), and pharmaceutically acceptable salts and solvates thereof, wherein the compound is in free drug particulate form, is disclosed.
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6809099 |
Saframycins, analogues and uses thereof
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods...
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6806272 |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
The present invention relates to new dihydropteridinones of the formula (I) wherein the groups X, R 1 , R 2 , R 3 , R 4 , R 5 and R 7 have the meanings given in the claims and the...
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6803366 |
Agent for improving learning or memory
Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such...
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6803367 |
Substance for inducing apoptosis
A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance.
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6800627 |
Pirazino indole derivatives
Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the...
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