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4303659 |
Schistosomicidal compositions
Certain novel schistosomicidal pharmaceutical compositions are disclosed. These compositions involve the concomitant use of two different organic chemical compounds each chosen from a separate...
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4291033 |
Oxoimidazoquinoxalines
Novel oxoimidazoquinoxalines of the formula ##STR1## wherein R 1 and R 2 are individually selected from the group consisting of hydrogen, chlorine and bromine, X is selected from the group...
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4285947 |
Aldehyde adducts of triamterene
The invention provides novel aldehyde adducts of triamterene having improved solubility and bioavailability as compared to triamterene. Pharmaceutical compositions containing the novel adducts and...
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4283400 |
Medicated animal feed based on liver meal
The invention relates to the provision of medicated animal feeds comprising one or more pharmaceutically active compounds and liver meal as a formulation auxiliary. Also included in the invention...
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4271073 |
6-Substituted-9-(2-hydroxyethyl)-1,2,3,4-tetrahydro carbazol-1-one
The present invention relates to new, pharmacologically valuable 2,4,5,6-tetrahydro-1H-pyrazino-[3,2,1-jk]-carbazoles substituted in the 8-position having the formula I ##STR1## wherein R stands...
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4258043 |
Pyrazino-carbazoles, process for the production thereof and pharmaceutical agents
The present invention relates to new, pharmacologically-valuable antidepressants, which are 2,4,5,6-tetrahydro-1H-pyrazino-[3,2,1-jk]-carbazoles substituted in the 8-position and having the formula...
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4254123 |
Novel imidazoquinoxalines
Novel imidazoquinoxalines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, --NH 4 , alkali metal, alkaline earth metal, magnesium,...
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4251529 |
Ergot peptide alkaloids
Compounds of formula I ##STR1## wherein R 1 is alkyl of 1 to 4 carbon atoms or benzyl, R 2 is alkyl of 1 to 4 carbon atoms, and either (i) A is .CH 2 .CH 2 .COOH; .CH 2 .CH(OH).COOH or...
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4242344 |
Piperazinyl-imidazo[1,2-a]pyrazines
Piperazinyl-imidazo[1,2-a]pyrazines, derived from reactions between halo-imidazo[1,2-a]pyrazines with piperazine derivatives, are found to be active anorexic, antidepressant, antihypertensive,...
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4239763 |
α-Blocking agents in the treatment of obesity
Alpha-blocking agents, especially 9,10-dihydroergot-peptide alkaloids, are anti-obesity agents.
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4229451 |
Ergopeptine derivatives
This invention provides new compounds of formula I, ##STR1## wherein R is branched chain alkyl of 3 to 6 carbon atoms, useful as venoconstrictors and venotonics.
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4229452 |
Treatment of inflammatory disorders with 4-trifluoromethylimidazo[1,2-a]quinoxaline
A method for treating inflammatory disorders in mammals which comprises administering to said mammals having an inflammatory disorder a therapeutically effective amount of...
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RE30415 |
Substituted pyrroloquinoxalinones and diones
Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
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4226868 |
Processes for inhibiting the growth of sea urchin eggs
The growth of sea urchin eggs is inhibited with a composition comprising a methine dye having a reduction potential equal to or more negative than -1.0 volt which is capable of being absorbed by...
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4225605 |
Ergolene or ergoline compounds for treating congestive heart failure
A method for the treatment of congestive heart failure in animals comprises administering a therapeutically effective amount of an ergolene or ergoline having dopaminergic activity to an animal in...
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4220636 |
Stabilized suppositories containing ergo-alkaloids
The present invention relates to stabilized suppositories containing ergo-alkaloids and/or their derivatives, characterized in that SO 2 -releasing substances are added in a finely dispersed state...
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4219555 |
2-Bromoergosine and pharmacologically compatible acid addition salts thereof as well as their use for the treatment of arterial hypertension and or heart arrythmias
2-Bromoergosine of the formula: ##STR1## and acid addition salts thereof. The acid addition salts are employed in the treatment of arterial hypertension and of heart arrythmias.
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4210645 |
(1,4)Dithiino(2,3-b)(1,2,5)-thiadiazole(3,4-e)pyrazine-6,7-dicarbonitrile
The novel compound (1,4)Dithiino(2,3-b) (1,2,5)-thiadiazole(3,4-e)pyrazine-6,7-dicarbonitrile, its method of use in the control and kill of bacteria and fungi, and compositions containing the novel...
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4203987 |
3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H) -ones
Disclosed herein are compounds of the formula: ##STR1## wherein n is an integer from 1 to 8; R is hydrogen or lower alkyl; Y is hydrogen, lower alkyl, lower alkoxy, chlorine, fluorine, or...
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4202897 |
Prolactin secretion inhibitors
Certain known imidazo[2,1-a]isoindoles and isoquinolines, e.g., 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5H-imidazo[2,1-a]is
oindole (mazindol), have been found to be useful as inhibitors of...
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4199581 |
1,4-Dithiino pyrazine tetracarbonitriles
Novel 1,4-Dithiinopyrazinetetracarbonitriles are disclosed. Their method of use in the control and kill of bacteria and fungi, and compositions containing the novel compounds as the active...
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4195086 |
6-Branched chain alkyl sustituted ergot alkaloids
This invention provides new compounds of formula I, ##STR1## wherein R 1 is alkyl or 2 to 5 carbon atoms, and R 2 is methyl or ethyl, useful as anti-migraine agents and for the treatment of...
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4191767 |
Method for treating fungal infection in mammals with imidazo [1,2-a]quinoxalines
A method for treating a fungal infection in mammals which comprises administering to said mammals having a fungal infection a therapeutically effective amount of a 4-(substituted...
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4191766 |
Method for reducing immunological response
A method for reducing the immunological response in mammals by the administration of certain substituted phenyl or substituted anilino imidazo[1,2-a]quinoxalines.
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4188373 |
Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The...
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4187101 |
1-Acyloxymethyl-4,5-dichloro-imidazole derivatives and their use as herbicides
1-Acyloxymethyl-4,5-dichloro-imidazole-2-carboxylic acid derivatives of the formula ##STR1## in which X represents trifluoromethyl, cyano or a group ##STR2## in which R 1 represents a saturated or...
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4185991 |
4,5-Dichloro-imidazole derivatives and their use as herbicides
A 4,5-dichloro-imidazole derivative of the formula ##STR1## in which X represents trifluoromethyl, cyano or a ##STR2## or ##STR3## in which R 1 represents a saturated or unsaturated aliphatic...
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4177055 |
1-Acyloxymethyl-4,5-dichloro-imidazole-2-carboxylic acid derivatives and their use as plant protection agents
Novel 1-acyloxymethyl-4,5-dichloro-imidazole-2-carboxylic acid derivatives of the formula ##STR1## in which X represents trifluoromethyl, cyano or a group ##STR2## in which R 1 represents an...
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4172133 |
(1,4)Dithiino(2,3-b)(1,3)thiazole-(4,5-e)pyrazine-6,7-dicarbonitriles
Novel (1,4)Dithiino(2,3-b)(1,3)thiazole-(4,5-e)pyrazine-6,7-dicarb
onitriles, the ir method of use in the control and kill of bacteria and fungi, and compositions containing the novel compounds as...
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4162319 |
Ring substituted pyrazino-isoquinoline derivatives and their preparation
Isoquinolines of the formula ##STR1## wherein R 1 is H, OH, alkyl; R 2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R 3 is H, alkyl or hydroxy alkyl; R 4...
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4157394 |
Cardio-protective pharmaceutical composition
A cardio-protective pharmaceutical composition is disclosed, which composition comprises an inert carrier and a pharmaceutically-effective amount of a combination of...
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4151280 |
Pyrroloquinoxalines
Novel pyrroloquinoxalines of the formula ##STR1## wherein X and Y are individually selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5 carbon atoms and --NO 2 , Z is...
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4133884 |
Substituted pyrroloquinoxalinones and diones used in treating inflammation in warm blooded mammals
Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
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4128641 |
Tetracyclic psychotropic drug
A method of treating patients having a psychiatric condition such as schizophrenia, or having an anxiety syndrome or other neurosis, comprising administering to such patient a therapeutically...
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4128646 |
Pyrimido[5,6-b]quinoxaline-4-(3H)-one-2-carboxylic acid compounds
Substituted pyrimido[5,6-b]quinoxaline-4(3H)-one-2-carboxylic acid compounds each represented by the formula ##STR1## wherein: R designates a member selected from the group consisting of hydrogen,...
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4122177 |
Method of treating oligospermia and asthenospermia
The present invention relates to a new use of an active agent selected from compounds of formula I, ##STR1## wherein R 1 is hydrogen or alkyl of 1 to 5 carbon atoms, R 2 is hydrogen, alkyl of...
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4096262 |
Pour-on anthelmintics
An anthelmintic composition suitable for pour-on application to animals for the treatment of helmintic infections which comprises from 0.5 to 40 parts by weight of an anthelmintic agent which is...
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4091099 |
6-Hydrocarbon-ergopeptines
This invention provides new compounds of formula I, ##STR1## wherein R 1 is hydrogen, alkyl of 2 to 8 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms, and R 2 is branched alkyl of 3 or 4...
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4089958 |
2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
Compounds of the formula ##STR1## WHEREIN R is hydrogen (lower)alkyl, phen(lower)-alkyl, benzoyl(lower)alkyl, or p-halobenzoyl-(lower)alkyl; R 1 is hydrogen or (lower)alkyl; R 2 is hydrogen,...
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4032639 |
2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension
Compounds of the formula ##STR1## wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R 1 is hydrogen or (lower)alkyl; R 2 is hydrogen,...
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4008322 |
Triazolo(4,3-a)quinoxalines for control of rice
A new method of reducing the adverse effects of rice blast, an important disease of rice, is disclosed. The method comprises applying a compound chosen from a class of triazolo[4,3-a]quinoxalines...
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3993760 |
Pyrazinoisoquinolines as anthelmintic agents
(-)-2-Benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-
a]isoquinoline is prepared by benzoylation of (-)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquino
line, or cyclization of a...
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3993759 |
Anthelmintic
2-Benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]is
oquinoline is used as an anthelmintic against cestodes and trematodes, preferably in admixture with a pharmaceutically acceptable carrier.
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3988455 |
Ditetrazolo(1,5-a:5',1'-c)quinoxalines for control of soil-borne phytopathogens
A class of ditetrazolo[1,5-a:5',1'-c]quinoxalines has been found to be useful for protecting plants from soil-borne phytopathogens, such as fusarium root rot, rhizoctonia damping-off and...
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3987196 |
Tetrazolo(1,5-a)quinoxalines for control of phytopathogens
The protection of plants from foliar and soil-borne phytopathogens is accomplished by the treatment of the plants with a specified class of tetrazolo[1,5-a]quinoxalines.
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3985879 |
Antibacterial compositions containing a 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxide and method of using same
4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxides of the formula: ##SPC1## Wherein R is hydrogen, a straight or branched chain saturated or partially unsaturated substituted or unsubstituted...
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3984554 |
Animal fodder compositions containing a 4-amino-pyrimido-( 4,5,b)-quinoxaline-5,10-dioxide and method of using same
4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxides of the formula: ##SPC1## Wherein R is hydrogen, a straight or branched chain saturated or partially unsaturated substituted or unsubstituted...
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3959470 |
Psychotropic medicinal preparation
A psychotropic medicinal preparation comprising a therapeutically effective amount of an active principle which is a salt of 3-methyl-8-methoxy-3H,...
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3935312 |
Combating fungi with imidazo-[4,5-b]quinoxalines
Fungicidal compositions, containing and methods of combating fungi using, imidazo[4,5-b]quinoxalines of the general formula ##SPC1## In which R is lower alkyl or halo-lower alkyl, R 1 is...
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3896228 |
Method for treating nephrises
This invention concerns a novel method of increasing urine volume and urine pH, which comprises inhibiting prolactin by administering a prolactin inhibiting amount of a prolactin-inhibitor selected...
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