|
Match
|
Document |
Document Title |
|
|
7608594 |
Novobiocin analogues as anticancer agents
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present...
|
|
|
7605136 |
Effector conjugates, methods for their preparation and their pharmaceutical use
Conjugates of epothilones and epothilone derivatives (as effectors) with suitable saccharides or saccharide derivatives (as recognition units) are described. Their production is carried out by the...
|
|
|
7582618 |
2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
The 3′-L-valine ester of β-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery,...
|
|
|
7576064 |
Pyrazole derivative, drug composition containing the same and production intermediate therefor
The present invention provides pyrazole derivatives represented by the general formula:
wherein R 1 represents H, an optionally substituted C 1-6 alkyl, etc.; one of Q and T represents a...
|
|
|
7576063 |
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
The present invention provides pyrazole derivatives represented by the general formula:
wherein R 1 represents H, an optionally substituted C 1-6 alkyl group etc.; one of Q and T represents a...
|
|
|
7572774 |
Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of...
|
|
|
7569557 |
Compositions of estrogen-cyclodextrin complexes
Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition...
|
|
|
7566699 |
Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
The present invention provides fused heterocyclic derivatives represented by the general formula:
wherein R 1 represents H, halogen, OH, etc.; R 2 represents H, halogen or an alkyl group; R 3...
|
|
|
7557091 |
HKI10311129, novel antibiotic, method for producing the same and the use thereof
The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C 56 H 75 NO 22 . The invention also relates to a method for producing said...
|
|
|
7557089 |
Use of derivatives of succinate esters for the treatment of dementia
The use of extract form Wangla ( coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for...
|
|
|
RE40837 |
Lignan complex derived from flaxseed as hypercholesterolemic and anti-atherosclerotic agent
A method is described for treating hypercholesterolemic atherosclerosis or for reducing total cholesterol while raising high-density lipoportoein cholesterol. It involves administering to a patient...
|
|
|
7553819 |
Multivalent inhibitors of serum amyloid P component
Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such,...
|
|
|
7544668 |
Saponins derived from Ilex pubescens and method of purifying the same
Two hitherto unreported novel triterpene saponins were isolated in substantially pure form from the root of Ilex pubescens . The chemical structures and some properties of the triterpene saponin...
|
|
|
7544667 |
Hypocholesterolemic compounds
The present invention relates to novel hypocholesterolemic compounds of formula (I) useful in the treatment and prevention of atherosclerosis and for the reduction of cholesterol levels as well as...
|
|
|
7541342 |
Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of...
|
|
|
7541341 |
Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
The present invention provides glucopyranosyloxybenzylbenzene derivatives represented by the general formula:
wherein P represents a hydrogen atom or a group forming a prodrug; R 1 represents...
|
|
|
7538092 |
Pharmaceutically active oligosaccharide conjugates
The present invention relates to pharmaceutically active oligosaccharide conjugates having the formula: (X—Y m ) n —S, wherein component X is a pharmaceutically active compound, Y is a...
|
|
|
7534768 |
Treatment of DNA viral infections
The synergistic combination of a loop diuretic and a cardiac glycoside is useful in the treatment of DNA viral infections.
|
|
|
7531646 |
β-D-ribosidase activity indicators with a chromogenic substrate
This invention provides a method of detecting enzyme activity on a solid medium. The enzyme substrate has a chromogenic portion comprising a catechol residue, in which a derivitising moiety is...
|
|
|
7531519 |
Polygalatenosides and use thereof as an antidepressant agent
A polygalatenoside useful as an antidepressant agent having the formula is disclosed:
wherein R, R′ and R″ independently are H or R 1 , provided that R, R′ and R″ are not all H, wherein...
|
|
|
7524822 |
Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments
The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]
-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation...
|
|
|
7524821 |
Scaffolded maleimide clusters for multivalent peptide assembly
Disclosed are scaffolded maleimide clusters, methods of making said clusters and use of said clusters as templates for multivalent peptide assembly. Multiple maleimide functionalities were...
|
|
|
7524510 |
Alkyl-glycoside enhanced vaccination
Described herein are methods for the noninvasive immunization of a subject that involve alkyl glycosides. Also described herein are compositions, kits, and devices for the noninvasive immunization...
|
|
|
7514411 |
Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , W, Y, and Z are defined herein; or a...
|
|
|
7511022 |
Substituted indole-O-glucosides
Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
|
|
|
7511020 |
Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for...
|
|
|
7504477 |
Polyalkylene glycol acid additives
A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small...
|
|
|
7501399 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods...
|
|
|
7491805 |
Conjugates and compositions for cellular delivery
This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactosamine and N-acetyl galactosamine derived conjugates of...
|
|
|
7488491 |
Use of glycosylceramides as adjuvants for vaccines against infections and cancer
The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition...
|
|
|
7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
|
|
|
7470671 |
Thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therapeutics
The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the method for their preparation and to their use as active principles of drugs...
|
|
|
7465712 |
Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula:
wherein R 1 represents a hydrogen atom or a hydroxy(lower alkyl) group; and R 2 ...
|
|
|
7446098 |
Combination therapy for treating protein deficiencies
This application provides methods of improving gene therapy by combining gene therapy with active site-specific chaperones (ASSCs). The ASSC increases the stability and efficiency of the protein...
|
|
|
7435756 |
Preparation and diabetic use of gibberellins
The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of...
|
|
|
7435726 |
Compositions and methods for the treatment of cancer
This invention relates to compositions comprising thalidomide and another anti-cancer drug which can be used in the treatment or prevention of cancer. Preferred anti-cancer drugs are topoisomerase...
|
|
|
7432247 |
Methods of cardioprotection using dichloroacetate in combination with an inotrope
The present invention provides compositions and methods for maintaining cardiac function by administering dichloroacetate (DCA) in combination with an inotrope.
|
|
|
7419960 |
Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens
Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root of Ilex pubescens . The chemical structures and some properties of these hemiterpenes...
|
|
|
7419958 |
Method of attenuating reactions to skin irritants
The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful...
|
|
|
7414072 |
Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
There is provided a 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate...
|
|
|
7399472 |
Vaccines
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
|
|
|
7396818 |
Sulfotransferase inhibitor
The hexuronic acid derivative represented by the following formula 1 or a salt thereof is used as an active ingredient of a heparin/heparan sulfate sulfotransferase inhibitor.
In the formula,...
|
|
|
7393937 |
N-acetylglucosamine derivatives and use thereof
The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external...
|
|
|
7393837 |
Inhibition of PEX in the treatment of metabolic bone diseases
The present invention relates to a method of treating metabolic bone diseases in a patient, which comprises the modulation of PEX activity to modulate the bone micro-environmental concentrations of...
|
|
|
7390785 |
τ-conotoxin peptides
The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
|
|
|
7387999 |
Simmondsin for use as angiogenesis inhibitor
Methods of inhibiting angiogenesis in humans and animals by administering a effective amount of a secondary plant metabolite from jojoba, having the general formula I shown below, are disclosed....
|
|
|
7387790 |
Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells...
|
|
|
7384920 |
Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases
This invention relates to a new use of stilbene derivatives or pharmaceutically acceptable salts thereof, especially in the manufacture of medicament for the prevention and treatment of diabetes or...
|
|
|
7378398 |
Method for treating cancer
A method for treating an adenocarcinoma excluding colon cancer, lung cancer and gastric cancer, comprising administering to a subject in need thereof and suffering from adenocarcinoma cancer, a...
|
|
|
7378104 |
Delivering substances to invertebrate organisms
Particles ( 10 ) for controlling, treating, feeding of aquatic invertebrate filter feeding organisms such as mussels, clams, oysters and insect larvae comprising a biologically active ingredient (...
|