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8106007 |
Conjugates of a polypeptide and a pentasaccharide
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being...
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8106022 |
Carbohydrate conjugates as delivery agents for oligonucleotides
The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein:A and B are each independently for each occurrence O, N(RN) or S;X and Y are each...
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8097593 |
Lipid A and other carbohydrate ligand analogs
The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further...
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8092780 |
Polyvalent conjugate vaccine for cancer
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated...
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8093227 |
Monosaccharide compounds and methods therefor
A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds...
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8088743 |
Methods for treating obesity employing an SGLT2 inhibitor
Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in...
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8080527 |
Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease, and transplant rejection
The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in...
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8080539 |
Method of treating human preeclampsia employing resibufagenin
A method of treating preeclampsia including administering a therapeutically effective dose of resibufagenin to a patient having preeclampsia. Effecting the determination of the presence of...
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8076466 |
Saccharidic fluorescent substrates, their process of preparation and their use
The present invention relates to fluorescent enzymatic substrates of saccharidic nature having a self-cleavable spacer arm functionalized by a fluorophore F and by at least one inhibitor of the...
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8071758 |
Method for production of limulus-positive glycolipid, the limulus-positive glycolipid, and composition containing the limulus-positive glycolipid
It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and...
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8071558 |
Application of D-psicose to suppression of abnormal circadian increase in blood glucose level
A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing...
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8058413 |
Molecular transporters based on sugar and its analogues and processes for the preparation thereof
The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and...
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8058245 |
Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
The present invention provides fused heterocyclic derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an...
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8053417 |
Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for...
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8053416 |
Isolation and structure of turbostatins 1-4
Described herein are novel cerebroside compounds, designated as Turbostatin 1, Turbostatin 2, Turbostatin 3, and Turbostatin 4. These compounds were extracted and isolated from the marine mollusk...
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8048860 |
Butanol extract of Bidens pilosa
A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or...
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8048868 |
Method of preventing preeclampsia
A method of preventing preeclampsia including administering to a patient during an early stage of pregnancy a prophylactically-effective amount of resibufogenin. The administration of resibufogenin...
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8044029 |
Sulfatides for treatment of autoimmune disorders
Disclosed herein are methods for the treatment of autoimmune or immune related diseases or disorders. Also disclosed are methods for treating such autoimmune or immune related diseases or disorders...
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8026221 |
Method, composition and kit for antigenic binding of norwalk-like viruses
A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with...
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8022043 |
Ceramide derivatives as modulators of immunity and autoimmunity
α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the anti...
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8003615 |
Stable vitamin B6 derivative
A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents a glycosyl group, a phosphate group, or a cyclic phosphate group bound to R2; R2 represents...
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7998739 |
Methods of activating NKT cells
Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from...
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7998943 |
Core 2 GlcNAc-T inhibitors III
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising administration of a therapeutically effective...
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7998935 |
Quinaldine based semisquaraines and squaraine dyes, process for preparation thereof and use thereof
The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3 and/or pharmaceutically acceptable...
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7994141 |
Compositions comprising compounds of natural origin for damaged skin
The present invention relates to a skin-protecting composition for the damaged skin, comprising glycyrrhizin, quercetin, rosmarinic acid, madecassic acid, chamazulene, bicalein and emodin. The...
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7994140 |
Classes of compounds that interact with GPCRs
The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I),...
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7989422 |
Antibacterial agents
The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as...
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7989423 |
6″-amino-6″-deoxygalactosylceramides
This invention relates to galactosylceramide compounds.
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7989424 |
Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one...
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7985435 |
Triterpene compositions and methods for use thereof
The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic...
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7977318 |
Derivative of glucose and of vitamin F, compositions comprising it, uses and preparation process
An O-acyl product derived from glucose which may be obtained by partial or total esterification of glucose and of vitamin F, comprising a mixture of esters, for example, monoesters, of glucose and...
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7977319 |
Ultra-high fiber supplement and method of reducing weight, cardiovascular risks and ingested toxins
An improved ultra-high fiber supplement that promotes satiety, caloric reduction, and weight loss. The supplement comprises guar, oat, psyllium, locust bean gum, pectin, green tea,...
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7973014 |
Medicinal composition containing ginseng secondary glycosides, its preparation method and application
Medicinal composition containing ginseng secondary glycosides, its preparation method and application. The present composition contains mainly, as active ingredients, the ginsenoside with...
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7968522 |
Treatment and prophylaxis of sepsis and septic shock
A method and composition for the prophylaxis or treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.
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7968596 |
Preparation and diabetic use of Gibberellins
The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of...
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7964581 |
Use of difructose anhydride-containing composition
A method for improving bowel movement of a subject desiring such an improvement, includes administering to the subject a defructose anhydride (DFA) in an amount effective to improve bowel movement.
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7964568 |
Synthesis of high molecular weight iron-saccharidic complexes
A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH)− ions and (...
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7960353 |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
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7956041 |
Prophylactic and therapeutic agent of diabetes mellitus
The invention provides a prophylactic and therapeutic agent of diabetes mellitus, including a combination of an inhibitor of renal glucose reabsorption and a hypoglycemic agent. In accordance with...
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7956039 |
Use of amygdalin analogues for the treatment of psoriasis
The compounds of formula (I), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C≡CH; R2, R3, R4 and R5 are r...
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7943586 |
Antineoplastic agents targeted via glut transporters
The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the...
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7943594 |
Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for...
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7939502 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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7935672 |
Derivatives of genkwanin and sakuranetin, cosmetic and therapeutic use thereof and preparation method of same
The invention relates to: (i) the use of osyl derivatives of genkwanin and sakuranetin having formula (I) in (a) cosmetics or dermatology and (b) therapeutics; (ii) the use of novel derivatives...
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7935685 |
Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment
A process for the preparation of inclusion complexes of a drug (piroxicam or ibuprofen) and a cyclodextrin, characterised in that: a) the drug and cyclodextrin, in the form of finely divided...
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7932233 |
Fungal phytotoxin fusicoccin for the treatment and diagnosis of coagulation-correlated pathologies
The present invention concerns the use of tricyclic terpenes chosen from the group consisting of fusicoccin, ophyobolins or cotylenins for the therapy and diagnosis of coagulation-correlated...
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7932232 |
Cosmetic composition comprising beta-fructosyl-L-ascorbic acid for skin whitening
The present invention is related to novel cosmetic composition comprising beta-fructosyl-L-ascorbic acid derivatives produced by fructose conversion reaction using by ascorbic acidskin whitening...
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7932237 |
Pharmaceutical compositions for use in the treatment of wounds
A pharmaceutical composition that can be used in the treatment of wounds, comprising at least a sulfated polysaccharide and wherein the polysaccharide/s are in the form of solids as powder, flakes...
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7928079 |
Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
The invention relates to compounds capable of releasing nitric oxide wherein the compounds comprise a saccharide and at least one nitric oxide-releasing diazeniumdiolate [N2O2] functional group,...
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7928090 |
External preparation composition
An external preparation composition used for preventing or treating symptoms or diseases related to dermatopathy caused by dryness, UV rays and aging such as wrinkles and sags of the skin,...
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