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5795874 |
Water soluble antibiotics
The compound of the formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined herein, are described. These compounds are antibacterial agents.
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5788985 |
Vaccine composition for eliciting an immune response against N-glycolylated gangliosides and its use for cancer treatment
The invention provides novel uses for n-glycolylated gangliosides, or derivatives and/or oligosaccharides thereof. The invention further provides methods of obtaining such gangliosides, as well as...
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5789385 |
Sialyl Lewis.sup.x mimetics containing phenyl backbones
Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups,...
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5780442 |
Orthosomycins from micromonospora carbonacae
Orthosomycins have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africana designated SCC 2146. These compounds are antibacterial agents. Compositions...
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5780443 |
Water-soluble retinoids
The invention relates to water-soluble sugar retinoids (I) and to their preparation and the use thereof as medicaments and in the cosmetic sector, wherein X is a sugar radical attached at an oxygen...
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5780445 |
Tocopheryl glycosides, their preparation, and their use as surfactants, as antioxidants and as the active substance preventing cell ageing in cosmetic or pharmaceutical preparations
Tocopheryl glycosides of the general formula ##STR1## or of the general formula ##STR2## where n can adopt values of 0-6 and where R represents a radical from the group consisting of H, branched...
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5780441 |
Sphingoglycolipid compounds and therapeutic uses thereof
The present invention relates to a sphingoglycolipid represented by the formula (I): ##STR1## wherein R 1 , R 2 and R 5 represent H or a specific monosaccharide; R 3 and R 6 represent H or OH,...
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5776460 |
Processed ginseng product with enhanced pharmacological effects
A processed ginseng product with enhanced pharmacological effects is provided due to a heat-treatment at a high temperature of 120° to 180° C. for 0.5 to 20 hours so as to make a ratio of...
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5773421 |
Antifungal fusacandins
Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R 1 wherein R 1 is alkenyl, C 2 -C 12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-,...
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5773419 |
Method of treating cancer with tannic acid
A pharmaceutical composition including tannic acid and tannin complexes, and a method of treating cancer with tannic acid and tannin complexes.
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5773001 |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from...
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5773420 |
Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
This invention relates to acylated benzylglycosides and a method for their use as smooth muscle cell proliferation inhibitors and as therapeutic compositions for treating diseases and conditions...
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5770204 |
Composition for mucosa treatment with saponin
The instant invention is a composition based upon a triterpene saponin having a particular application for inclusion in the diets of vertebrates to reduce or eliminate the colonization of bacteria...
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5767095 |
Anti-inflammatory compositions containing monogalactosyl dieicosapentaenoyl glycerol and methods relating thereto
Disclosed are topical anti-inflammatory compositions containing 0.1% to 10% by weight of a monogalactosyl dieicosapentaenoyl glycerol having esterified eicosapentaenoic acid residues (MGDG-EPA);...
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5767149 |
α-glycosyl-L-ascorbic acid, and it's preparation and uses
α-Glycosyl-L-ascorbic acid exhibiting no direct reducing activity is formed in a solution containing L-ascorbic acid and an α-glucosyl saccharide when subjected to the action of a...
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5767094 |
Propiophenone derivative and processes for preparing the same
A propiophenone derivative the formula I!: ##STR1## wherein R' is a lower alkanoyl group and R" is a hydrogen atom, or R' is a hydrogen atom and R" is a lower alkoxycarbonyl group, or a...
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5767093 |
Methods for attenuating antibody-mediated xenograft rejection in human recipients
Antibody-mediated xenograft rejection is attenuated by parenterally administering a xenoantibody-inhibiting amount of an identified carbohydrate xenoantigen to the recipient shortly before graft...
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5767092 |
Treatment of radiation-damaged bone marrow using galactosyl ceramides
The present invention relates to a pharmaceutical composition (a marrow cell proliferation accelerator, a radioprotective agent, a therapeutic agent for thrombocytopenia) comprising a compound...
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5767104 |
Use of sulfated saccharides to treat baldness
A method of treating and/or preventing alopecia (baldness, deficient hair growth) comprises administering to a patient in need thereof a therapeutically or prophylactically effective amount of a...
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5763413 |
Lewis-associated compound, process for producing the same, and anti-inflammatory
A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R 1 and R 3 represent each hydrogen, m SO 3 H or CH 2 COOH;...
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5760008 |
Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors
According to the present invention, a substrate for cytochrome p450 which, after oxidation by cytochrome p450, reacts with thiol groups is conjugated to a saccharide to provide a tumor-specific...
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5756470 |
Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
Hypocholesterolemic sugar-substituted 2-azetidinones are disclosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the...
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5756471 |
Use of a sophorolipid to provide free radical formation inhibiting activity or elastase inhibiting activity
The present invention relates to a cosmetic and/or dermatological composition comprising at least one sophorolipid in its crude or acid form or associated with a monovalent or divalent salt. The...
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5753630 |
Method for treating and inhibiting gastric and duodenal ulcers
A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I ...
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5753631 |
Intercellular adhesion mediators
The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions...
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5750150 |
Compositions for treating affected tissues, method for the preparation and usage thereof
Injectable compositions for treating affected tissues are prepared by formulating sodium hydrogen sulfite with all other components except tannic acid to yield a first mixture and adding tannic...
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5750508 |
Sialic acid/fucose based medicaments
Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally...
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5747461 |
Synergistic administration of cyclosporine and fructose diphosphate
This invention discloses a method of using fructose-1,6-diphosphate (FDP) to help suppress the rejection of internal organs such as kidneys, hearts, etc. At least three major advantages of FDP in...
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5747463 |
Malonate derivatives of glycolipids as cell adhesion inhibitors
There is provided a novel series of malonate derivatives of glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid: R 1 is --(CHCH) m --(CH 2 ) n --CH 3 ...
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5739116 |
Enediyne derivatives useful for the synthesis of conjugates of methyltrithio antitumor agents
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from...
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5739115 |
Sulfated maltooligosaccharides with heparin-like properties
A novel class of highly sulfated maltooligosaccharide having heparin-like activity is described, as well as methods for using these oligosaccharides to treat certain diseases including cancer, and...
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5739117 |
Agent for improving cerebral metabolism including glucose ester derivatives
An agent for improvement of cerebral metabolism, containing as active ingredient a glucose ester derivative presented by the formula: ##STR1## and wherein the anomeric substitute in the formula is...
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5736523 |
Antineoplastic heteronapthoquinones
This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as...
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5736522 |
Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical composition
A compound of the formula (I): ##STR1## wherein R 1 and R 2 are, independently, a hydrogen atom, a monosaccharide residue, a protected monosaccharide residue, or a protecting group for hydroxyl...
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5733892 |
Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same
This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their...
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5731292 |
Dihydrochalcone derivatives which are hypoglycemic agents
A method for prophylaxis or treatment of diabetes, which comprises administering to a patient with diabetes an effective amount of a dihydrochalcone derivative of the formula I!: ##STR1## wherein...
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5719129 |
Derivative of caffeic acid, oraposide, and cosmetic or pharmaceutical compositions, in particular dermatological compositions, containing it
The invention relates to a new derivative of caffeic acid. This new derivative has the formula I below: ##STR1## in which one or more R independently represent a hydrogen atom, a C 1 -C 5 alkyl...
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5710133 |
α-glycosyl derivative of catecholamine or its salt, and its preparation and uses
Disclosed is a novel α-glycosyl derivative of a catecholamine or its salt, said α-glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without...
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5707817 |
Carbohydrate-based vaccine and diagnostic reagent for trichinosis
The present invention relates to Trichinella diagnostic reagents that include a β-tyvelose-containing composition and use of such reagents to detect Trichinella, and particularly Trichinella...
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5705489 |
Bisconjugates comprising two saccharides and a spacer
The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one...
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5703059 |
Disaccharide ligands for selectins
Compounds of formula (I), or a salt, solvate or hydrate thereof, wherein Z represents a divalent group selected from those of formulae I(a) to I(g) defined in the specification; Y represents a...
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5700784 |
External preparation for skin
An external preparation for the skin comprising at least one of the glycosides or hydroxysaliyclic acid and/or the glycosides of aliphatic esters of hydroxysalicylic acid represented by the...
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5695738 |
Steroidal C-glycosides
Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of...
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5695652 |
Methods for inhibiting the production of slime in aqueous systems
Methods for inhibiting the attachment of microbes to surfaces in aqueous systems are disclosed. Tea extracts and/or tannins are added to aqueous systems, such as papermaking and cooling water...
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5693621 |
Malonic acid derivatives having antiadhesive properties
The invention relates to malonic acid derivatives, which inhibit the binding of selectin to carbohydrate ligands, and pharmaceutical compositions and diagnostic agents containing these derivatives,...
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5688772 |
Quinoa saponin compositions and methods of use
Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful for enhancing mucosal absorption of a drug administered therewith.
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5686426 |
Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
There is provided a novel series of O-carboxymethylated α- and β-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid; R 1 is --(CHCH) m --(CH 2 ) n ...
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5686132 |
Glucans having a cycle structure, and processes for preparing the same
The present invention provides glucans and derivatives thereof which are useful as raw materials in the starch processing industries, food and drink compositions, food additive compositions, and...
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5679653 |
Diagnosis and treatment of bacterial dystentery
Diagnostic and therapeutic compositions which comprise the αGal(1-4)βGal subunit are described. These compositions permit the rapid diagnosis and treatment of enteric infections caused by E. coli...
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5679354 |
Matrix with immunomodulating activity
The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponim but no intentional antigenic determinants and optionally also adjuvants for...
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