Patents in Class 514/249

Matches 1 - 50 out of 1248

Match	Document	Document Title
1	8178530	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the...
2	8178535	Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments Substituted sulfonamide compounds corresponding to the formula I′ wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions c...
3	8178131	Pyrrolopyridines as kinase inhibitors Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in...
4	8178536	Sirtuin modulating compounds Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing...
5	8173656	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the...
6	8173618	Formulations for reducing neuronal degeneration Nutriceutical and pharmaceutical formulations for treating neurodegenerative disorders such as Alzheimer's disease are provided. Nutriceutical formulations include two or more of folate, vitamin E,...
7	8168637	Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of diabetes The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in whi...
8	8163751	Acylated indanyl amines and their use as pharmaceuticals The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1-R4 have the meanings given in the description, A is CH2, CHOH or CH—(C1-C3-alkyl), B is C...
9	8163750	Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90 The present invention relates to compounds of formula (I): wherein R1, R2, R2′, L, Het, p and p′ are as defined herein, compositions containing them, and their use as medicinal products.
10	8163725	Gel compositions and methods of use Improved topical gel compositions for the treatment of skin disorders are described. The gel compositions contain carbomer and methylparaben, and are substantially free of methylparaben crystalline...
11	8158634	Compounds and compositions as inhibitors of cannabinoid receptor 1 activity The invention provides compounds having Formula Ia, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and Y are as defined in the specification; as well as pharmaceutical...
12	8158629	Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with...
13	8158628	Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R1, R2a, R2b, R3a, R3b, R4, R8, R9a, R9b, R10, R11, A, B, W1, W2 and W3 have the meanings defined herein,...
14	8153647	Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics Disclosed are compounds according to formula (I): wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical...
15	8148369	Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and...
16	8148376	3, 4-dihydroquinoxalin-2(1H)-ones for use as stearoyl CoA desaturase inhibitors The present invention discloses 3,4-dihydroquinoxalin-2(1H)-ones for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases,...
17	8143254	Methods for modulating ion channels In one embodiment, the invention provides an ion having the formula: (I) In another embodiment, the invention provides a method for modulating potassium, sodium, and cyclic nucleotide-modulated ion...
18	8143247	Combinations for the treatment of diseases involving cell proliferation Disclosed are pharmaceutical compositions for the treatment of diseases which involve cell proliferation. Also disclosed are methods for the treatment of said diseases, comprising co-administration...
19	8133890	Combination of brimonidine and timolol for topical ophthalmic use Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for...
20	8129384	Imidazo[1,2-a]pyrazines as orexin receptor antagonists This invention relates to imidazopyrazine substituted piperidine derivatives and their use as pharmaceuticals.
21	8129383	Aminopterin dosage forms and methods for inflammatory disorders There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt...
22	8129372	Compounds having NPY Y5 receptor antagonistic activity This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or...
23	8124653	Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia Disclosed is a composition that includes a tetrahydrobiopterin in a controlled-release pharmaceutical preparation. Also disclosed is a method of treating a patient with phenylketonuria that...
24	8119637	Substituted pyrrolo[2,3-b]pyrazines and methods for kinase modulation, and indications therefor Compounds active on Fms and/or Kit protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of Fms and/or Kit...
25	8119636	Pyrrolopyrazine kinase inhibitors The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful...
26	8119621	Tetrahydro-cyclopentyl pyrazole cannabinoid modulators This invention is directed to a tetrahydro-cyclopentyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor...
27	8114893	Compounds and methods of use In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In...
28	8114867	Oxazolidinone antibiotic derivatives The invention relates to antibacterial compounds of formula I wherein R1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent CH, one or two of U, V, W and X represent(s) N and...
29	8114422	Methods and compositions for reducing skin damage The Notch signal transduction pathway has been identified as a target for screening and treatment methods for the prevention and/or reduction of short- and long-term UVB-induced skin damage, e.g.,...
30	8114871	3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention further relates to...
31	8110576	Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds have the formula: In certain aspects...
32	8106052	Luminescence-based methods and probes for measuring cytochrome P450 activity The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their...
33	8106051	Utilities of amide compounds Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or...
34	8106050	Derivatives of pyrrolo-pyrazines having a kinase inhibitory activity and their biological applications The invention relates to pyrrolo[2,3b]-pyrazine derivatives having the general Formula (I) wherein R2 and R3 are identical or different and represent H, C1-C6 alkyl, said alkyl being a straight or...
35	8101613	6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment...
36	8101614	Substituted pyrrolo [1,2-a] pyrazines as calcium channel blockers The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as...
37	8101626	GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto The present invention relates to the use of GPR119 receptor agonists for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an...
38	8097611	Sulfonyl-derivatives as novel or histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their...
39	8092840	Dietary supplement and a method to enhance sleep and lucid dreaming A nutritional supplement for enhancing sleep and lucid dreaming in humans. It contains a combination of ingredients in proportions calculated to enhance lucid dreaming. The primary ingredients are...
40	8088753	Heparin conjugates and methods Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the...
41	8088770	Modulators of pharmacokinetic properties of therapeutics The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that...
42	8080550	Anesthetic compositions and methods of use The invention generally relates to anesthetic compositions comprising low doses of a selective a-2 adrenergic receptor agonists in combination with anesthetic agents. The invention also relates to...
43	8071597	Pyrazine compounds and uses as PI3K inhibitors The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular...
44	8071599	Methods of treatment of chronic pain using eszopiclone The invention relates to the use of eszopiclone for the treatment of low-level, chronic pain and fatigue associated with pain.
45	8071598	3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions...
46	8071595	1,2-disubstituted heterocyclic compounds 1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and...
47	8071557	Treatment of pulmonary hypertension with carbonic anhydrase inhibitors This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating...
48	8067415	Compounds useful as antagonists of CCR2 The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the...
49	8067416	Methods and compositions for the treatment of metabolic disorders The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and...
50	8058269	Oxindole derivatives There is provided compounds of the formula wherein R6, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents.

Matches 1 - 50 out of 1248

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