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6525056 |
Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders
Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress...
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6525027 |
Use of ribose supplementation for increasing muscle mass and decreasing body fat in humans
Ribose administered to humans performing weight-training exercise provides more rapid increase in muscle mass and decrease in body fat than weight-training exercise without ribose.
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6525048 |
Azabicyclic 5HT1 receptor ligands
The present invention relates to compounds of the formula These compounds are useful as psychotherapeutic agents.
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6518270 |
Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof
The present invention relates to heterocyclic compounds of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or...
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6514973 |
Compositions for the treatment and prevention of neurological and pathopsychological diseases
This invention relates to a composition containing the three active ingredients: a) one or more phosphatidyl serines, b) one or more methyl transporters, and c) one or more compounds selected from...
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6514988 |
Condensed-ring thiophene derivatives, their production and use
A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or...
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6511990 |
Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
The present invention provides the compound having the formula: wherein each of R 1 and R 2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino,...
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6506555 |
Use of HIV protease inhibiting compounds
The invention relates to the use of at least one compound that inhibits HIV (human immunodeficiency virus) protease, selected from ritonavir, saquinavir or one of the pharmaceutically acceptable...
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6506753 |
Methods of making and using N-desmethylzopiclone
The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in...
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6500827 |
Drug combinations
This patent application describes a new combination treatment of selective, noradrenaline-reuptake inhibitors (NARI) and specifically, reboxetine, and pindolol to provide rapid relief to patients...
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6500829 |
Substantially pure diastereoisomers of tetrahydrofolate derivatives
The present invention related to the preparation of substantially pure diastereoisomers of derivatives of tetrahydrofolate and the use of such diastereoisomers. More particularly the present...
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6495551 |
Substituted phenyloxazolidinones and their use as antibiotics
The invention concerns compounds of formula (I), wherein, for example, R 1 is of the formula —NHC(═O)R a wherein R a is (1-4C)alkyl; R 2 and R 3 are independently hydrogen or fluoro; R...
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6482829 |
Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
The invention relates to compounds of the formula as described herein and pharmaceutically acceptable acid addition salts thereof. The described compounds have a good affinity to the NK1 receptor.
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6482859 |
Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives
The invention relates to novel pesticidally active compounds of the general formula I as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R 1 is...
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6479505 |
6-arylphenanthridines with PDE-IV inhibiting activity
Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.
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6472404 |
HIV protease inhibitors
The present invention discloses novel isoquinoline carboxamide derivatives which are HIV protease inhibitors or prodrugs thereof, a process for their manufacture, pharmaceutical compositions and...
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6472394 |
MCH antagonists and their use in the treatment of obesity
Disclosed are compounds represented by structural formula I: or a pharmaceutically acceptable salt, ester or solvate thereof, wherein W is R 1 —CR 3 R 12 NR 4 C(O)— or R 11 C(O)NR 4 —; the...
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6469006 |
Antiviral indoleoxoacetyl piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl...
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6465507 |
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to...
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6465491 |
6-phenylpyridyl-2-amine derivatives
The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and...
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6465464 |
Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury
The present invention provides a method of providing neuroprotection to a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on its nerve cells...
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6458791 |
Methods of treating muscle spasms using N-desmethylzopiclone
The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in...
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6455507 |
Benzimidazole derivatives
Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of...
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6451796 |
Fused pyrazine compounds
The compound of the formula (I): wherein all the symbols are meaning the same as descriptions of the specification; and salts thereof. The compounds of the formula (I) have inhibitory activity...
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6451803 |
N-acyl and n-aroyl aralkyl amides useful in treating seritonergic disorders
This invention relates to the use of a compound of the formula wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the disclosure, for treating or preventing migraine, depression and...
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6448244 |
Water soluble azoles as broad-spectrum antifungals
The present invention concerns novel water-soluble azole compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof;...
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6444673 |
Optically active 5H-pyrrolo&lsqb 3,4-b&rsqb pyrazine derivative, its preparation and pharmaceutical compositions containing it
Dextrorotatory isomer of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonylox
y]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, its preparation and pharmaceutical compositions containing it...
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6444700 |
Product and method to reduce stress induced immune suppression
In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress....
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6440971 |
Binuclear complex
A binuclear DNA-threading transition metal complex with the general formula: (L1)-M1-(D1-B-D2)-M2-(L2) wherein D1-B-D2 is a bridging ligand; D1 is a polycyclic heteroaromatic ligand in which aza...
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6440976 |
Iminopyrimidine NMDA NR2B receptor antagonists
Compounds described by the chemical structural formula or a pharmaceutically acceptable salt thereof, are useful in the treatment of pain, migraine, depression, anxiety, schizophrenia,...
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6440955 |
Reverse-turn mimetics and methods relating thereto
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: ...
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6436936 |
Methods and compositions for treating disorders, using optically pure (&plus ) zopiclone
Methods and compositions are disclosed utilizing the optically pure (+) isomer of zopiclone. This compound is a potent drug for the treatment of sleep disorders, such as insomnia, and convulsive...
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6436925 |
Substituted benzamides, their production and their use as cysteine protease inhibitors
Benzamides of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the...
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6429207 |
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating...
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6426346 |
6-membered aromatics as factor Xa inhibitors
The present application describes 6-membered aromatics of formula I: or pharmaceutically acceptable salt forms thereof, wherein D may be CH 2 NH 2 or C(═NH)NH 2 , which are useful as...
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6423349 |
Therapeutic nutrient composition for pre and post elective surgery
Compositions comprising glutamine in combination with other nutrients, including N-acetyl-cysteine and Vitamins A, C, E are disclosed. Such compositions can be administered for promoting recovery...
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6420365 |
Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R 1 , R 3 , R 4 , R 5 , and R 6 are variables defined herein, which...
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6420342 |
Nutritional preparation comprising ribose and medical use thereof
Trauma, surgery, inflammation, subfertility, lactation problems, gut disorders, infant nutrition, cancer, arthritis and other joints problems, vascular problems and cardio- or cerebro vascular...
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6420363 |
Mono- or polyenic carboxylic acid derivatives
To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic...
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6413963 |
Reverse-turn mimetics and methods relating thereto
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have...
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6410536 |
Quinoxalinones as serine protease inhibitors such as factor XA and thrombin
This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically...
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6410535 |
Prophylactic or therapeutic agents for diseases having vascular dysfunction associated with insulin resistance
It is an object of the present invention to provide a pharmaceutical composition for effectively preventing or improving diseases having vascular dysfunction associated with insulin resistance. The...
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6407100 |
Fungicidal aromatic oximes
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
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6407109 |
Pyrrolyl tetrahydroquinoxalin diones, their production and use in the treatment of diseases
Pyrrolylquinoxalinediones of the formula I and their tautomeric and isomeric forms, and their physiologically tolerated salts, where the variables have the following meanings: R 1 hydrogen,...
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6403587 |
Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of MIP-1-α binding to its CCR 1 receptor
Compounds of the formula wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification are useful to treat inflammation and other immune disorders.
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RE37729 |
4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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6399610 |
Transmucosal formulations of levosimendan
A method of administering transmucosally, particularly to oral or nasal mucosa, levosimendan or a pharmaceutically acceptable salt thereof to a patient. The method comprises contacting an intact...
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6399609 |
Therapeutic usage of tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
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6391871 |
Preventing neuronal degeneration in Alzheimer's disease
A method of treating Alzheimer's disease is disclosed, not just with palliatives, but in a manner that prevents the progressive degeneration caused by Alzheimer's disease. Certain types of...
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6391878 |
Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
This invention involves compounds having the following structure: as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts,...
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