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6693112 |
Compounds for enhancing chemotherapy
The present invention provides 2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamines, of the formula: or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , and R 7 are as defined...
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6686358 |
Bicyclic amino-pyrazinone compounds
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
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6686359 |
Growth hormone secretagogues
This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the specification, which are growth hormone...
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6680328 |
8-azabicyclo&lsqb 3.2.1&rsqb oct-2-ene and -octane derivatives
The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their...
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6677336 |
Substituted piperazine compounds
Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage...
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6673797 |
Heterocyclic indole derivatives and mono- or diazaindole derivatives
There is provided a compound represented by the general formula (1): wherein Het represents an optionally substituted heterocyclic group; A 1 and A 2 each independently represent —CH═,...
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6667302 |
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
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6656931 |
Vasopressin antagonist and diuretic combination
This invention provides methods of increasing urine flow in humans while minimizing the loss of electrolytes or ions, the methods comprising administering to a human in need thereof a combination...
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6653309 |
Inhibitors of IMPDH enzyme technical field of the invention
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
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6653320 |
Imidazopyridine derivatives
The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel...
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6642259 |
Immune stimulating dietary supplement and method of use thereof
The immune system of middle aged and elderly individuals is stimulated with a dietary supplement. The dietary supplement includes Vitamin E, Vitamin B6 and conjugated linoleic acid. The dietary...
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6642228 |
α1b-adrenergic receptor antagonists
There are provided compounds represented by the general formula (I): [wherein Ar is indole etc., R 1 is hydrogen etc., B is bond, or B—N—R 1 forms a ring structure and is piperidine etc.,...
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6641834 |
Compositions containing alpha-2-adrenergic agonist components
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid...
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6638933 |
Bicyclic imidazo-3-yl-amine derivatives
Substituted bicyclic imidazo-3-yl-amines and medicaments comprising these compounds, useful, inter alia, as analgesics.
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6635620 |
Hydroxyproline derivatives
The present invention relates to hydroxyproline derivatives represented by the following general formulas and the therapeutic agent containing the same for the impaired organs and tissues. ...
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6632813 |
6-subtituted-7-heteroquinoxalinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both
The invention provides compounds with antagonism against excitatory amino acid receptors, in particular, AMPA receptor having 6-substituted-7-heteroquinoxalinecarboxylic acid derivatives and...
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6630472 |
Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation
Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting...
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6623736 |
Interleukin antagonists for the treatment of neurological, retinal and muscular disorders
Interleukin (IL) antagonists are provided for the treatment in humans of neurological disorders, trauma, injuries or compression; neurodegenerative disorders including Alzheimer's Disease;...
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6620816 |
Method for treating tumors by the administration of tegafur, uracil, folinic acid, and cyclophosphamide
This invention provides a method of treating a tumor in a warm-blooded animal, including humans, by administering, in combination, an anti-tumor effective amount of tegafur, uracil, folinic acid or...
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6617339 |
Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and...
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6613772 |
Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments
Compounds of the formula I in which R 1 , R 2 , R 3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and...
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6613767 |
Stable aqueous folinate solution
A stable aqueous solution of folinic acid of up to about 400 mg/ml, which does not crystallize at refridgeration temperatures, is obtained by preparing an aqueous solution of sodium folinate.
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6608065 |
Use of cGMP phosphodiesterase inhibitors in methods to treat female sexual dysfunction
The use of (6R, 12 a R)-2,3,6,7,12,12 a -hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2
,1′:6,1]pyrido[3,4-b]indole -1,4-dione, (3S, 6R, 12 a R)-2,3,6,7,12,12 a...
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6602870 |
Oral dosage form for administration of the combination of tegafur, uracil, folinic acid, and oxaliplatin and method of using the same
This invention provides a dosage form and a method of administering an anti-tumor composition comprising tegafur, uracil and folinic acid to potentiate the coadministration of oxaliplatin.
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6602871 |
Thrombin or factor Xa inhibitors
This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the...
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6596721 |
Stable crystalline (6R) -tetrahydrofolic acid
Pure and extremely stable crystalline (6R)-tetrahydrofolic acids, absolutely inert even when exposed to air and elevated temperature without stabilizers being added, are prepared by a...
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6596727 |
Substituted pyrimidines, processes for their preparation, and their use as pesticides and fungicides
Substituted 4-amino- and 4-alkoxy-cycloalkylpyrimidines, processes for their preparation, and their use as pesticides and fungicides The invention relates to compounds of the formula in which R 1...
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6589952 |
Imidazo&lsqb 1,2-a&rsqb pyrazines for the treatment of neurological disorders
Provided herein are novel imidazo[1,2-a]pyrazines of Formula I: wherein: X is CHR 5 , NR 5 , O, S, S(O) n or a single bond, wherein n is equal to 0, 1 or 2; D is aryl or heteroaryl attached...
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6583152 |
Composition for reducing the risk or progression of cardiovascular diseases
Elevated levels of homocysteine have been implicated as an important risk factor for cardiovascular and other diseases. A composition for decreasing levels of plasma homocysteine and a method for...
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6576666 |
Nutritional supplements
The present disclosure relates to novel nutritional compositions containing linoleic acid and/or linolenic acid which optimize child neurological development and provide improved nutritional...
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6576634 |
Pharmaceutical or dietetic preparation for improvement of fertility and sperm quality
A composition for improving the fertility of a male, and/or for improving the quality of the semen produced by a male includes at least one source of folic acid, preferably 0.05-8 mg; at least one...
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6573265 |
Use of 1-(aminoalkyl)-3-quinoxaline-2-on derivatives for the preparation of compounds having an antioxidant action
The invention relates to the use of 1-(aminoalkyl)-3-quinoxaline-2-one derivatives, especially 1-diethylaminoethyl-3-quinoxaline-2-one derivatives of the formula (I), where R 3 is hydroxy, methoxy,...
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6569857 |
Dietary supplement
The present disclosure relates to novel nutritional compositions and methods for augmenting the possibility of conception while increasing nutritional stores to aid development of healthy embryos...
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6565891 |
Nutritional supplement for children
A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection...
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6562378 |
Nutritional supplement for adolescents
A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection...
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6562809 |
3-bicycloindole compounds
Described herein are compounds selective for a 5-HT1D receptor, which have the general formula:
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6559149 |
Methotrexate derivatives
Antirheumatic agent containing as an active ingredient a compound resented by the following general formula (II):
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6548500 |
Reverse-turn mimetics and methods relating thereto
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have...
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6548502 |
Dopamine D4 ligands for the treatment of novelty-seeking disorders
The present invention provides a method of treating or preventing a novelty-seeking disorder, such as pathological gambling, attention deficit disorder with hyperactivity disorder and sex...
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6548483 |
Nutritional preparation comprising ribose and medical use thereof
Trauma, surgery, inflammation, subfertility, pregnancy, lactation problems, gut disorders, infant nutrition, cancer, arthritis and other joint problems, vascular problems and cardio-or...
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6548501 |
Composition and methods for stimulating gastrointestinal motility
The present invention is directed to methods for stimulating the motility of the gastrointestinal system in a patient which comprises administering a growth hormone secretagogue, a prodrug thereof...
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6548499 |
Substituted quinoxaline derivatives as interleukin-8 receptor antagonists
Quinoxaline compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in...
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6544994 |
Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase
The invention relates to the use of at least folic acid or a folate and tetrahydrobiopterin (BH 4 ) or derivatives thereof for treating or preventing cardiovascular or neurological disorders by...
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6544995 |
Use of cysteine derivatives for preparing a medicine for treating pathologies resulting from the formation of heterotrimeric G protein
The invention relates to the use of cysteine derivatives for preparing a medicament intended to treat diseases which result from the formation of the heterotrimeric G protein. These diseases...
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6541523 |
Methods for treating or preventing fibromyalgia using very low doses of cyclobenzaprine
The present invention relates to methods and compositions comprising a very low dose of cyclobenzaprine or metabolite thereof for preventing and treating sleep disturbances and illnesses manifested...
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6537992 |
Regulation of organic nitrate tolerance
There is disclosed pharmaceutical compositions and methods useful in obviating or mitigating tolerance during organic nitrate therapy. The compositions and methods comprise compounds selected from...
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6537994 |
Heterocyclic β3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein, U, V, and W are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating...
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6531484 |
Pyrrolidine modulators of CCR5 chemokine receptor activity
Pyrrolidine compounds of Formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8a , R 8b , j, k, 1, m, and n are defined herein) are described. The compounds are modulators of CCR5...
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6528496 |
Compositions treating, preventing or reducing elevated metabolic levels
A method for orally administering vitamin preparations is described which combine vitamin B 12 (B 12 , cobalamin) and folic acid (folate), with and without pyridoxine (B 6 ), for preventing and...
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6525054 |
Cyanoiminoquinoxaline derivatives
A cyanoiminoquinoxaline derivative of the formula (II) is useful as a preventive or therapeutic agent for diseases due to hyperexcitation of glutamate receptors. (wherein, X and Y each is...
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