|
Match
|
Document |
Document Title |
|
|
6127373 |
Method of treating tourette's syndrome and obsessive compulsive disorder
A method for treating Tourette's syndrome, obsessive compulsive disorder, chronic motor or vocal tic disorder in a mammal, including a human, comprising administering to said mammal an effective...
|
|
|
6124291 |
Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
|
|
|
6121264 |
Imidazole-substituted quinoxalinedione derivatives
|
|
|
6117871 |
6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
The subject invention relates to methods of treating alpha-2 adenoreceptor modulated disorders, comprising administration, to a mammal in need of such treatment, of a safe and effective amount of a...
|
|
|
6117873 |
Substituted aminoalkane phosphonic acids
Compounds of the formula I ##STR1## in which R 1 is hydroxyl or an aliphatic, araliphatic or aromatic radical, X is a divalent aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic,...
|
|
|
6117872 |
Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity
NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO...
|
|
|
6114331 |
Substance suppressing allograft rejection
Use of a substance according to formula (I) including its tautomeric forms, stereoisomeric forms and salts ##STR1## for the production of a drug suppressing the immunoreaction, in particular...
|
|
|
6110935 |
Benzofurazan compounds for enhancing glutamatergic synaptic responses
Compounds of the general structural formula ##STR1## are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of...
|
|
|
6110911 |
Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the...
|
|
|
6107274 |
Piperazines as inhibitors of fructose-1,6-bisphosphatase (FBPase)
Compounds of formula A are disclosed: ##STR1## wherein R 1 is aralkyl or cycloalkyl; R 2 is cycloalkylmethyl, alkyl, or aralkyl; R 3 is hydrogen, alkyl, substituted phenyl (including...
|
|
|
6103722 |
Ischemic preconditioning
Methods and pharmaceutical compositions of matter are disclosed and claimed relating to cardioprotective effect mediated by delta (δ) opioid receptor agonists or more specifically delta-1 (δ 1...
|
|
|
6103723 |
Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
|
|
|
6103720 |
Ketobenzamides as calpain inhibitors
The patent describes ketobenzamides of the formula ##STR1## where R1, R2, R3, R4, X and n have the meanings given in the description, and their preparation. The novel compounds are useful for...
|
|
|
6096744 |
Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the...
|
|
|
6096743 |
1,2,3,4-tetrahydroquinoxalinedione derivative
A 1,2,3,4-tetrahydroquinoxalinedione derivative represented by the following formula (I) or salt thereof, an NMDA-glycine receptor and/or AMPA receptor antagonist or kainic acid neurotoxicity...
|
|
|
6093723 |
4-substituted beta-carbolines and analogs thereof
This invention relates to 4-substituted β-carbolines and β-carboline analogs that inhibit Ca +2 influx and interleukin-2 (IL-2) production. The 4-substituted β-carbolines and β-carboline...
|
|
|
6093703 |
Pharmaceutical compositions, containing S-adenosyl-L-methionine salt, 5-methyl-tetrahydrofolic acid and 5-formyltetrahydrofolic acid
For the therapy of neurological complications in AIDS sufferers, the use of pharmaceutical compositions containing as an active principle at least one compound selected from the group consisting of...
|
|
|
6087361 |
Aryl-imidazolines and aryl-imidazoles useful as α-2 adrenergic agonists without cardiovascular side effects
Methods are disclosed for treating a mammal with a condition that responds to α2 agonist treatment without causing cardiovascular side effects using compounds of the formula ##STR1## wherein R 1 ...
|
|
|
6083948 |
Tetrahydropteridines for treatment of neurological disorders
Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating anxiety, depression, and other psychiatric and neurological disorders are disclosed.
|
|
|
6083947 |
Method for treating sexual dysfunctions
This invention is a novel treatment for sexual dysfunctions by administering to a subject exhibiting a sexual dysfunction compounds that upmodulate the AMPA receptor. Methods and compositions for...
|
|
|
6080743 |
2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
2,3-Dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives of formula (I), ##STR1## wherein one of the radicals R 1 , and R 2 is a group R 5 and the other is a group of formula --CH(R 6 )--alk--R 7 ...
|
|
|
6075016 |
6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard...
|
|
|
6069151 |
Quinolines and their therapeutic use
Compounds of the formula ##STR1## have therapeutic utility, as inhibitors of phosphodiesterase IV and TNF release.
|
|
|
6066635 |
Avrainvillamide, a cytotoxic marine natural product, and derivatives thereof
The present invention provides a compound having the structure ##STR1## wherein, R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from H, alkyl, aminoalkyl, perfluoroalkyl, or...
|
|
|
6063784 |
Heteroaryloxyethylamines, method of preparation, application as medicine and pharmaceutical compositions containing them
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application and its non-toxic, pharmaceutically acceptable acid...
|
|
|
6057304 |
Quinoxaline-phosphonic acid derivatives
The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R 1 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the disclosure, as well as their production and use in...
|
|
|
6057321 |
1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their preparation and therapeutic application
The invention concerns compounds of general formula (I) ##STR1## in which R 1 represents a methyl group, X 1 represents a hydrogen atom, or OR 1 and X 1 together form a group of formula --O(CH...
|
|
|
6057314 |
Low molecular weight bicyclic thrombin inhibitors
This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof. As well, this invention relates to...
|
|
|
6057319 |
3,4-Diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors
The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for...
|
|
|
6048869 |
Tricyclic compounds
The novel compounds of the present invention are those of structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of...
|
|
|
6046190 |
Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as...
|
|
|
6042849 |
Unit dosage forms for treatment of vasoconstriction and related conditions
Magnesium is formulated in combination with vitamin E, vitamin C, folate, selenium, and optionally melatonin a unit dosage form for oral administration, for the treatment of vasoconstriction and...
|
|
|
6043240 |
3-heteroaryl-1-pyrrolidinealkylamines and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
|
|
|
6028071 |
Purified compositions of 10-propargyl-10-deazaaminopterin and methods of using same in the treatment of tumors
Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate...
|
|
|
6015557 |
Tumor necrosis factor antagonists for the treatment of neurological disorders
A method for inhibiting the action of TNF for treating neurological conditions in a human by administering a TNF antagonist for reducing damage to neuronal tissue or for modulating the immune...
|
|
|
6015800 |
Substituted quinoxaline-2-ones as glutamate receptor antagonists
A novel series of substituted quinoxaline 2-ones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds...
|
|
|
6011037 |
Thiazole derivatives with phosphodiesterase-inhibiting action
|
|
|
6004933 |
Cysteine protease inhibitors
The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and...
|
|
|
6001831 |
Process for producing quinazoline derivatives
A process for producing 1,2,3,4-tetrahydro-2,4-dioxo-quinazoline-1-yl acetic acid derivatives of the formula (I) in which R 1 , R 2 , R 3 and R 4 are mutually independently hydrogen, halogen, OH,...
|
|
|
5994359 |
Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof
2-Iminooxyphenylacetic acid derivatives ##STR1## where the substituents and the index have the following meanings: R 1 is C(CO 2 CH 3 )NOCH 3 (Ia), C(CONHCH 3 )NOCH 3 (Ib), C(CONH 2...
|
|
|
5994379 |
Bisaryl COX-2 inhibiting compounds, compositions and methods of use
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically...
|
|
|
5990111 |
Aldose reductase inhibition in preventing or reversing diabetic cardiomyopathy
This invention relates to the use of aldose reductase inhibitors in the treatment, prevention or reversal of diabetic cardiomyopathy in a human subject.
|
|
|
5985926 |
Method for inhibiting intracellular viral replication
There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an...
|
|
|
5985877 |
Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer
A method of treating prostate cancer by co-administering a tyrosine kinase inhibitor such as an indolocarbazole and a chemical castration agent is disclosed. A composition containing a tyrosine...
|
|
|
5985869 |
Benzoheterocyclic compounds
Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R 1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R 2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally...
|
|
|
5985860 |
System for transdermal delivery of pain relieving substances
Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other...
|
|
|
5981537 |
Pyrimidine-thioalkyl and alkylether compounds
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R 4...
|
|
|
5977113 |
4-heteroaryl-1-piperazine alkylamines and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
|
|
|
5972975 |
Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
|
|
|
5962455 |
Certain substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligands
This invention encompasses compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X 1 , X 2 , X 3 represent organic or inorganic substituents, n is 1, 2, or 3,...
|