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6265406 |
Substituted quinolin-2 (1H) -ones useful as HIV reverse transcriptase inhibitors
This invention relates generally to quinolin-2(1H)-ones and derivatives thereof of Formula (I): ##STR1## or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms...
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6262054 |
Combination therapy method for treating breast cancer using edatrexate
This invention provides combination therapy methods, pharmaceutical combinations and compositions for inducing tumor cell regression in cancer patients, particularly metastatic breast cancer...
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6261600 |
Folic acid supplement
The present invention is directed to novel chewable or dissolvable nutritional supplements for improving the absorption of folic acid in humans and other animals and methods of using said...
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6258811 |
Methods for preventing, inhibiting or treating graft rejection reactions in graft-versus-host disease (GVHD) and organ transplantation
The present invention provides remedies for graft-versus-host disease (GVHD) and graft rejection reactions in organ transplantation which comprise retinoic acid receptor (RAR) agonists as an active...
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6251903 |
Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's...
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6251893 |
Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are independently selected from the group...
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6251906 |
Retroviral protease inhibiting compounds
The present invention discloses novel compounds, compositions, and methods for inhibiting retroviral proteases and in particular for inhibiting human immunodeficiency virus (HIV) protease. The...
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6245760 |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56 lck tyrosine kinase activity, to pharmaceutical compositions comprising these...
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6235742 |
5-substituted pyrazolo[4,3-D]pyrimidin-7-ones
Compounds are disclosed which are useful as PDE1 inhibitors. The compounds have the formula: ##STR1##
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6235747 |
6-phenyl-pyridin-2-ylamine derivatives
The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and...
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6218400 |
Treatment method using a cGMP-Specific PDE inhibitor
A compound of formula ##STR1## and salts and solvates thereof, wherein R 0 , R 1 , and R 2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor...
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6218393 |
Anthranilic acid derivatives as multi drug resistance modulators
Anthranilic acids of formula (I): ##STR1## wherein each of R to R 9 is an organic substituent, n is 0 or 1, m is 0 or an integer of 1 to 6, q is 0 or 1, X is a direct bond, O, S, --S--(CH 2 ) p ...
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6211196 |
Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists
Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of...
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6211220 |
Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives
A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to amino or pyridylamino cyclobutane derivatives.
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6207651 |
Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
A method for orally administering vitamin preparations is described which combine vitamin B 12 (B 12 , cobalamin) and folic acid (folate), with and without pyridoxine (B 6 ), for preventing and...
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6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
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6204266 |
Pharmaceutical, cosmetic and/or food composition having anti-oxidant properties
A pharmaceutical, cosmetic and/or food composition includes a pyrazine derivative of formula (I) or (II), and/or a precursor thereof of formula (III). The composition is used for treatment of...
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6200978 |
Compounds as delta opioid agonists
Compounds of the formula (I)--shown below--are described. ##STR1## The compounds are useful in the manufacture of a pharmaceutical composition for preventing or treating inflammatory diseases such...
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6200976 |
Antithrombotic quinoxazolines
Quinoxazolines having antithrombotic activity. Exemplary of those disclosed are: 4-{[6-(N-carboxymethyl-quinolin-8-yl-sulphonylamino)-1-methy
l-2-oxo-1,2-dih...
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6200979 |
Methods of administering CRF antagonists
Substituted pyrrazoles of the formula ##STR1## wherein R 1 , R 2 , R 3 , X, Y, Z and A are as defined herein with reference to formula I; pyrazoles and pyzazolopyrimidines of the formula ##STR2##...
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6200607 |
Pharmaceutical composition comprising at least tyrosine and an iron compound for treating parkinson's disease or depression
A pharmaceutical product comprises the use of a combination of tyrosine and iron for separate, sequential or simultaneous administration for the treatment of Parkinson's disease or depression. In a...
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6197773 |
N-acyl and N-aroyl aralkyl amides as serotonergic agents
A compound of the formula ##STR1## wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined above, useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 ...
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6191134 |
Amide derivatives of substituted quinoxaline 2, 3-diones as glutamate receptor antagonists
A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the...
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6191133 |
Treatment of depression and pharmaceutical preparations therefor
It has been found that the treatment of depression using known serotonin reuptake inhibitors (SRIs) and noradrenaline reuptake inhibitors (NRIs) may be improved by the administration therewith of...
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6191132 |
Use of quisqualate receptor antagonists
The new use of antagonists of the AMPA receptor complex and its physiologically compatible salts as pharmaceutical agents for prevention and treatment of Parkinson's disease as well as...
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6187752 |
Method for treating schizophrenia employing an ace inhibitor
A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or...
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6184221 |
Sulfonamide-substituted compounds, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for...
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6172065 |
Urea and thiourea derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the...
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6169092 |
3-Ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes
3-Urea-pyridofurans and -pyridothiophenes are prepared by reacting appropriately substituted 3-amino-pyridofurans or -pyridothiophenes with isocyanates or isothiocyanates. The 3-urea-pyridofurans...
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6169097 |
1-(1,2-Disubstituted piperidinyl)-4-substituted piperidine derivatives
The present invention concerns compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m...
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6166041 |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH 2 ...
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6165987 |
Anthelmintic formulations
A veterinary composition containing an effective amount of praziquantel, an effective amount of at least one macrolide anthelmintic selected from the group comprising the avermectins and the...
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6166019 |
Piperazinyl pyrimidine dione compounds selective for adrenoceptors
Compounds of Formula I and II and their pharmaceutically acceptable, salts, esters and prodrugs thereof are selective alpha-1D adrenoceptor anatagonists and may be useful for treating disease states.
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6166008 |
Treatment of schizophrenia with ampakines and neuroleptics
This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order...
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6162806 |
Active oxygen scavengers containing pterin derivatives
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6162803 |
Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
Compounds effective in treating disorders of the serotonin-affected neurological symptoms are provided, such compounds having the following formula: ##STR1## wherein: R 1 and R 5 are each,...
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6159986 |
Compounds and therapy for resisting memory loss in humans
Therapies and compounds for the inhibition of memory loss. In one embodiment, a combination of Huperzine A and hypericin is employed.
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6159505 |
Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine
Compositions for the treatment and prevention of migraine or stress headaches wherein there is supplied a combination of potassium, magnesium and pyridoxine optionally in association with other...
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6159975 |
Antagonists of gonadotropin releasing hormone
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
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6159506 |
Method for self-regulating stress-reduction using folic acid enriched dietary supplement compositions
A food supplement compositions combining suitable precursor substrates with folic acid, whereby methionine is produced in sufficient quantity to produce a sufficient quantity of met-enkephalin...
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6156751 |
Certain tricyclic substituted diazabicyclo (3.2.1) octane derivatives
This invention encompasses compounds of the formula: ##STR1## where either R 1 or R 2 represents ##STR2## and the other represents hydrogen or straight or branched chain lower alkyl having 1-6...
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6156766 |
Benzamide compounds and pharmaceutical use thereof
Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical...
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6153608 |
Isoquinoline derivatives and drugs
The invention relates to a compound of the following general formula [I] or a medicinally acceptable salt thereof, or a solvate thereof, ##STR1## wherein R 1 represents alkyl, alkenyl, alkynyl,...
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6143733 |
Quinoxalinedione derivatives, their production and use in pharmaceutical agents
Quinoxalinedione derivatives ##STR1## as well as their production and use in pharmaceutical agents are described.
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6143746 |
Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
A compound of formula (I) and salts and solvates thereof, in which: R 0 represents hydrogen, halogen, or C 1 -6 alkyl; R 1 represents hydrogen, C 1 -6 alkyl, C 2 -6 alkenyl, C 2 -6 alkynyl, haloC...
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6140325 |
Thienopyrimidine derivatives, their production and use
Thienopyrimidine derivatives are disclosed. Also disclosed are methods for the production and use of these compounds.
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6136805 |
Quinoxaline dione derivatives, their production and their use in medicaments
Quinoxalinedione derivatives of formula (I) ##STR1## are described, and their use in pharmaceutical agents.
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6129918 |
Method and pharmaceutical composition for reducing serum homocysteine concentration
A method and composition are described for reducing the elevated plasma homocysteine level in mammals (humans) by oral administration of a therapeutically effective amount of Allium plants or...
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6127363 |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
A method is provided for treating erectile dysfunction, e.g., vasculogenic erectile dysfunction such as vasculogenic impotence. The method involves the administration of a Type IV phosphodiesterase...
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6127368 |
Anellated β-carbolines
Compounds of formula I ##STR1## are described, as well as the process for their production and their use in pharmaceutical agents.
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