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5719155 |
Chroman derivative and pharmaceutical use thereof
Chroman derivatives of the formula I! ##STR1## wherein R 1 is a cyano, a nitro, a trihalomethyl, a trihalomethoxy or a halogen atom; R 2 is a lower alkoxyalkyl, an aryloxyalkyl or a...
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5716956 |
Dihydrophthalazine antagonists of excitatory amino acid receptors
Substituted dihydrophthalazine compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders...
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5716954 |
Benzopyridazinone and pyridopyridazinone compounds
Benzo or pyridopyridazinones and pyridazinthiones of the formula ##STR1## wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur; R 1 is...
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5714479 |
Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.
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5705501 |
Certain substituted 1-aryl-3-morpholinopropanones to treat Alzheimer's Disease
Disclosed are compounds of formula I: ##STR1## wherein X is selected from oxygen, sulfur and NR; wherein R is selected from hydrogen, loweralkyl and CH 2 CH 2 COAr 1 ; and Z is hydrogen;...
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5696130 |
Tricyclic steroid receptor modulator compounds and methods
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
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5693640 |
Pyridazino-indole derivatives
A class of pyridazino 4,5-b!indole-1,4-dione derivatives, substituted in the 2-position by an optionally substituted phenyl moiety, are selective non-competitive antagonists of NMDA receptors...
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5688803 |
Tricyclic dicarbonyl derivatives
Compounds of general formula (Ia), (Ib) and (II), wherein R 1 and R 2 each independently signify hydrogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, amino, halogen, cyano or R 3 R 4 ...
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5688793 |
Pyridazino 4',5':3,4!pyrrolo- 2,1-a!-isoquinolines and the use thereof for preparing pharmaceutical preparations
The invention relates to new pyridazino 4',5':3,4!-pyrrolo 2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids and complex-forming agents,...
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5679677 |
Heterocyclic carbamates, process for their preparation and medicaments
The invention relates to heterocyclic carbamates of the formula (I) ##STR1## processes for their preparation and medicaments containing them.
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5677304 |
9-amino-pyridazino 4'5':3,4!pyrrolo- 2,1-a!isoquinolines and the use thereof for the production of pharmaceutical preparations
The invention relates to the use of 9-amino-pyridazino- 4',5':3,4!pyrrolo 2,1-a!isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with acids, bases and...
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5658917 |
Isoquinolines having adenosine uptake inhibitor activity
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a...
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5652247 |
Carbostyril derivatives
Novel carbostyril derivatives of the formula: ##STR1## wherein R 1 is H, NO 2 , alkoxy, alkoxycarbonyl, alkyl, halogen, optionally substituted amino, OH, CN, COOH, alkanoyloxy, hydrazinocarbonyl;...
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5652239 |
Pyridazinedione derivatives useful in treatment of neurological disorders
The present invention relates to pyridazino[4,5-b]indoles, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is...
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5652235 |
Method of using spiro piperidines to promote the release of growth hormone
There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote...
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5648353 |
Quinazolines and phthalazines having adenosine uptake inhibitor activity
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a...
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5643911 |
Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia
A method is provided for treating a disease caused by smooth muscle cell hyperplasia. According to this method, there is administered to a patient suffering from said disease a therapeutically or...
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5639745 |
Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
Disclosed are compounds, compositions and methods for inhibiting interleukin-1β protease activity. The compounds, bicyclic derivatives of aldehydes and α-substituted methyl ketones, have the...
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5635504 |
Diazepine containing dual action inhibitors
Compounds of the formula ##STR1## wherein: ##STR2## A is are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors.
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5631253 |
Fungicidal propenoic acid derivatives
Compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C 1 -4 alkyl, C 1 -4 alkoxy, C 1 -4 haloalkyl, C 1 -4 haloalkoxy, C 1 -4 alkylcarbonyl, C...
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5624921 |
Hypotriglyceridemic aminoacetylmercapto derivatives
The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.
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5624926 |
Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a...
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5609867 |
Polymeric antitumor agents
This invention provides novel antitumor agents having the formula: ##STR1## wherein A, B, G, W, R 1 , R 2 , R 3 , n, m and Z are described in the specification which have activity as anticancer...
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5610157 |
N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
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5605900 |
Benzotriazines having adenosine uptake inhibitor activity
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a...
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5602131 |
EburnanE analogues
A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Z are as...
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5602122 |
Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylmercapto derivatives
The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.
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5599815 |
Antipsychotic benzoisothiazolyl piperazine derivatives
Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent...
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5591762 |
Benzimidazoles useful as angiotensin-11 antagonists
Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R 1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R 2 is, inter alia, optionally...
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5574038 |
5,6-cyclicimidazo [1,5-a] Quinoxalines
The invention discloses imidazo[1,5-a]quinoxalines (I) ##STR1## which do not contain an endocyclic carbonyl group that are useful as anxiolytic and sedative/hypnotic agents.
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5569658 |
Tricyclic derivatives
The invention concerns tricyclic derivatives of the formula I ##STR1## wherein R 1 and R 2 together form an optionally substituted group of the formula --NCH--NH--, --NCH--O--,...
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5569669 |
Alkylaminoindane compounds
The invention relates to a compound selected from those of formula (I): ##STR1## in which R 1 , R 2 , R 2 ', R 2 ", R 2 '", R 3 and n are as defined in the description, an optical isomer, and an...
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5565472 |
4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof wherein R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such...
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5565455 |
Method for treating substance abuse disorders
A method for relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse and/or for the suppression of dependence on drugs or substances of abuse which...
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5556856 |
Phthalazinone derivatives that modulate multi-drug resistance
Phthalazinone derivatives and their optical isomers are used as medications to combat heart rhythm disturbances, to combat pain and to break through multi-drug resistance.
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5556851 |
Cinnoline-3-carboxylic acid derivatives
A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT 3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and...
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5554610 |
Inhalational treatment of pulmonary hypertension and related conditions
A method for the treatment and/or prophylaxis of disorders associated with pulmonary hypertension and/or disorders associated with right heart failure, in mammals, such as humans, which method...
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5550127 |
Method of treatment for eiph in racing stock
The prevention and treatment of exercise-induced pulmonary hemorrhaging in non-human mammals is accomplished by the timely administration of effective amounts of vasodilators, including angiotensin...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5543410 |
Pharmacological use of phthaloylhydrazide derivatives; combination and application thereof
The invention pertains to use of phthaloylhydrazide derivatives and salts thereof as anti-inflammatory and antitoxic agents in human and veterinary medicine, and it pertains in particular to use of...
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5538970 |
Treatment of cancer with imidazo-1,2-pyridazin compounds
Compounds of general formula (I) ##STR1## wherein R 1 represents an optionally substituted carbocyclic or heterocyclic aryl group, or an optionally substituted alkyl, alkenyl, cycloalkyl or...
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5534515 |
Pyrrolopyridazines having gastrointestinal protective effects
Compounds of formula (I) ##STR1## wherein R1 stands for alkyl or R5-substituted alkylene; R2 stands for alkyl; R3 stands for hydrogen, halogen, --CHO (formyl), hydroxymethyl, nitro, amino, or the...
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5532243 |
Antipsychotic nitrogen-containing bicyclic compounds
There are provided nitrogen-containing bicyclic compounds, pharmaceutical compositions containing these compounds and methods of using these compounds to treat physiological or drug-induced...
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5519024 |
Quinolonecarboxylic acid derivatives and their use
A composition comprises a 1,7-disubstituted-4-oxo-3-quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3-naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or...
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5516784 |
Anti-HIV (AIDS) agents
Compounds of formula ##STR1## wherein Ar, W, Z, Q, R 1 , U, and T are as set forth herein, are described. These compounds are active as agents against retroviruses and in particular against HIV.
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5514676 |
Amino-benzoic acids and derivatives, and methods of use
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
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5514675 |
Naphthyl bradykinin receptor antagonists
This invention provides methods of treating a physiological disorder associated with an excess of bradykinins in a mammal which comprises administering to a mammal in need of said treatment a...
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5512564 |
Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them
The present invention concerns thiazolo- 2,3-a!pyrrole and oxazolo- 1,2-a!pyrrole derivatives of formula I ##STR1## in which HET represents a heterocyclic ring with 3-7 ring atoms which can be...
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5512573 |
Use of phthaloylhydrazide derivatives as anti-hypoxic and defensive agents
The invention concerns the use of phthaloylhydrazide derivatives and their salts as anti-hypoxic and defensive agents, with special focus on the use of 5-aminophthaloylhydrazide and its salts, when...
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5510379 |
Sulfonate ACAT inhibitors
β-Carboxy sulfonates of the formula ##STR1## wherein R 1 is aryl, R 3 and R 4 are hydrogen or alkyl, Y is -O-, -S-, or -NR 2 -, and R 5 is alkyl or aryl are potent inhibitors of the enzyme...
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