|
Match
|
Document |
Document Title |
|
|
6063783 |
Analgesic use of triazolo-pyridazine derivatives
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives as shown in Formula I, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the...
|
|
|
6048854 |
2,3-diaminopropionic acid derivative
The present invention relates to a 2,3-diaminopropionic acid derivative of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof. The compounds of the present invention are useful...
|
|
|
6048869 |
Tricyclic compounds
The novel compounds of the present invention are those of structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of...
|
|
|
6048853 |
1-arylphthalazine antagonists of excitatory amino acid receptors
Substituted 1-arylphthalazine compositions with the formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are independently a) H, b) HO, c) R 11 O--, d) halogen, e) C1-C3-alkyl, f)...
|
|
|
6046196 |
Antispastic use of triazolo-pyridazine derivatives
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives, as shown in Formula I possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the...
|
|
|
6043242 |
Imidazopyridazines
Compounds of formula (I) ##STR1## in which the substituents and symbols have the meanings indicated in the description, are suitable for controlling Helicobacter bacteria.
|
|
|
6011037 |
Thiazole derivatives with phosphodiesterase-inhibiting action
|
|
|
5990106 |
Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
This invention relates to bicyclic amino group-substituted pyridonecarboxylic acid derivatives of the general formula A--Pri esters thereof and salts thereof, wherein: Pri is a pyridonecarboxylic...
|
|
|
5985878 |
Angiogenesis inhibiting pyridazinamines
This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; m is 2 or 3...
|
|
|
5985869 |
Benzoheterocyclic compounds
Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R 1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R 2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally...
|
|
|
5972975 |
Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
|
|
|
5965557 |
Method for prophylaxis and treatment of irritable bowel syndrome
A method for the prophylaxis and treatment of irritable bowel syndrome, which comprises administering a pharmaceutically effective amount of at least one compound selected from the group consisting...
|
|
|
5955464 |
4-anilinoquinazoline derivatives bearing a heteroaryl substituted at the 6-position and possessing anti-cell-proliferation properties
The invention concerns 4-anilinoquinazoline derivatives of the formula I ##STR1## wherein m is 1 or 2; each R 1 includes hydrogen, halogeno, (1-4C)alkyl and (1-4C)alkoxy; n is 1, 2 or 3; ...
|
|
|
5952335 |
Fused polycyclic heterocycle derivatives
Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or...
|
|
|
5948782 |
Pharmaceutical composition containing quinoline and quinazoline derivatives and novel compounds therefor
There is disclosed an anti-inflammatory agent comprising a compound of the formula (I): ##STR1## The quinoline compounds included in the compound (I) are novel and there is also disclosed processes...
|
|
|
5945419 |
Method for treating allergic rhinitis
A method for treating allergic rhinitis by administrating to a subject in need thereof an effective amount of a compound of the formula: ##STR1## wherein R 2 and R 3 independently represent a...
|
|
|
5942512 |
Method and composition for treating erectile dysfunction
Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration thereof, optionally together with a hydrophilic vehicle and optionally an...
|
|
|
5942511 |
Allylthiopyridazine derivatives and process for preparing the same
The, present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment or hepatic diseases induced by...
|
|
|
5929077 |
Thioproline-containing inhibitors of farnesyl protein transferase
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected b ##STR1## its enantiomers, diastereomers, and pharmaceutically acceptable salts and solvates...
|
|
|
5929114 |
Arylthio compounds
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
|
|
|
5925653 |
Substituted pyridines and pyrimidines processes for their preparation and their use as pesticides and fungicides
Substituted pyridines and pyrimidines, processes for their preparation and their use as pesticides and fungicides. The invention relates to compounds of the formula ##STR1## in which A is N or CH,...
|
|
|
5922712 |
Eosinophil chemotaxis inhibitor
A method for inhibiting eosinophil infiltration by administrating to a subject in need thereof an effective amount of a compound of the formula: ##STR1## wherein R 2 and R 3 independently...
|
|
|
5922711 |
8-substituted quinazolines, quinoxalines and benzopyridazines
A compound of the formula: ##STR1## wherein --X 3 X 2 --X 1 N-- is a group of the formula: ##STR2## R 1 is hydrogen or halogen, R 2 is halogen, R 3 is hydrogen, nitro, amino...
|
|
|
5905079 |
1,2,4-triazolo 4,3-b!pyridazine derivatives and their use
Certain 1,2,4-triazolo(4,3-b)pyridazines of formula ##STR1## including pharmaceutically acceptable salts thereof, wherein R 1 -R 8 are as defined in the disclosure, for the treatment, prophylaxis...
|
|
|
5891904 |
Use of inhibitors of phosphodiesterase IV
The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
|
|
|
5874433 |
Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as...
|
|
|
5869486 |
Fused pyrimidines and pyriazines as pharmaceutical compounds
The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene; Z is bond, alkylene or...
|
|
|
5866574 |
Pancreatitis remedy
The present invention relates to a prophylactic agent or a therapeutic agent of pancreatitis, containing an adenosine uptake inhibitor or a pharmaceutically acceptable salt thereof.
|
|
|
5863915 |
Substituted 4-arylbutyric acid derivatives as matrix metalloprotease
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have...
|
|
|
5861380 |
Serine protease inhibitors-keto and di-keto containing ring systems
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
|
|
|
5859008 |
Arylalkyl diazinones
Arylalkyl diazinone derivatives of the formula I ##STR1## and their physiologically acceptable salts, in which R 1 , R 2 , R 3 , R 4 , B, Q and X have the meanings indicated in claim 1, exhibit...
|
|
|
5855654 |
Pyridazinones as marine antifouling agents
Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying dihydropyridazinone and pyridazinone compounds onto or into the marine structure. These...
|
|
|
5852016 |
Quinoxaline derivatives useful in therapy
Compounds of formula (I), wherein A represents N or CH; R 1 and R 2 independently represent C 1 -4 alkyl, halo or CF 3 ; R 3 represents C 1 -4 alkyl (optionally substituted), C 3 -7 cycloalkyl,...
|
|
|
5834466 |
Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
A therapeutic and prophylactic method for protection of heart or heart tissue by limiting metabolic and ionic abnormalities developed during, following or associated with ischemia by administering...
|
|
|
5824677 |
Substituted amino alcohol compounds
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
|
|
|
5821244 |
Condensed nitrogen heterocycles and their use as pesticides, fungicides and antimycotics
Condensed nitrogen heterocycles, process for their preparation, and their use as antimycotics The invention relates to compounds of the formula ##STR1## in which two of the symbols A, B, D and E in...
|
|
|
5807854 |
Pyrimidone derivatives with antifungal activity
Compounds of general formula I and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these...
|
|
|
5789408 |
Antiviral thiazoles
Compounds of formula (I) are active antiviral compounds useful in the treatment of viral infections in mammals. The compounds of the invention are readily prepared by reaction of a suitable...
|
|
|
5786361 |
Pyridazino-, pyrimido-, pyrazino- and triazinoindoles, -pyrrolocycloalkenes or pyrrolooxocycloalkenes, or pyridopyrrolylpyrido compounds, compositions containing them, and use thereof to treat atherosclerosis
Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with...
|
|
|
5783576 |
Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions
New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
|
|
|
5776935 |
Pyrido-phtalazin diones and their use against neurological disorders associated with excitotoxicity and malfunctioning of glutamatergic neurotransmission
Pyridyl-phtalazin diones having the following formula: ##STR1## wherein R1 and R2 are selected from the group consisting of hydrogen, halogen, and methoxy or wherein R1 and R2 together form...
|
|
|
5773445 |
3-methoxy-phenyl-acrylic acid methyl esters
The application describes new 3-methoxy-2-phenyl-acrylic esters of the formula (I) ##STR1## in which R and Y have the meanings given in the description, a process for their preparation, and...
|
|
|
5756501 |
Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
This invention relates to novel compounds which bind to central cholinergic muscarinic M1 receptors and may be useful for treatment of diseases attributed to cholinergic insufficiency such as...
|
|
|
5756502 |
Quinazolinone derivatives as cholyecystokinin (CCK) ligands
Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them, methods of using them and a novel process for their...
|
|
|
5753655 |
1-arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation
1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and processes for making said derivatives are described. The novel derivatives are non-steroidal heterocyclic compounds...
|
|
|
5744471 |
Pyridazion quinoline compounds
The present invention relates to compounds, pharmaceutical compositions and methods of using compounds of formula (I) in the treatment and/or prevention of certain diseases or conditions. In...
|
|
|
5741793 |
Compositions having synergistic fungitoxic effects
Fungitoxic compositions exhibiting synergistic effects in the control of fungal growth are disclosed. The compounds are based on the combination of fatty acids and derivatives thereof with...
|
|
|
5739133 |
Pyridazinedione compounds useful in treating neurological disorders
The present invention relates to pyridazino 4,5-b!quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is...
|
|
|
5728712 |
3,4-disubstituted-phenylsulphonamides and their therapeutic use
3,4-Disubstituted-phenylsulphonamides have therapeutic utility via TNF or phosphodiesterase inhibition.
|
|
|
5719151 |
Substituted benzene compounds
Phthalazinedione compounds and pharmaceutical compositions are described. The compositions are useful in treating human or animal patients to alleviate or cure disease or disease symptoms caused by...
|