Matches 601 - 650 out of 712 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
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4721711 Pyridazine derivatives active on the central nervous system, and medicaments in which they are present  
The invention relates to the pyridazine derivatives of the formula: ##STR1## in which R 1 is H, a substituted or unsubstituted phenyl group, a naphthyl group, a cyclohexyl group, a thien-2-yl...
4716169 Imidazo[1,2a]pyridines and their use as cardiotonic agents  
The invention relates to new imidazo derivatives of the formula ##STR1## wherein "A-D and R 1 -R 3 are as defined in the specification". The new compounds have valuable pharmacological...
4716159 Pyridazino[4,3-c]-isoquinolines having anti-anxiety activity  
The present invention is directed to pyridazino[4,3-c]isoquinolines of Formula I ##STR1## wherein R represents methyl, phenyl or substituted phenyl groups, R 1 represents inter alia amino or...
4710496 Pyrrol-1-ylphenyldihydropyridazinones, their preparation and their use  
Novel pyrrol-1-ylphenyldihydropyridazinones of the formula ##STR1## their preparation and their use in the treatment of disorders.
4710504 Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor  
Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective α 2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives,...
4707479 Circulation active dihydropyridine-3-carboxamides  
1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the...
4701453 Substituted indeno-pyridazinones  
Substituted 2,5-dihydro- and 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
4698352 4-oxo-1,4-dihydronicotinic acid derivatives, salts thereof, and antibacterial agents containing the same  
This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R 1 is hydrogen or carboxyl-protecting group; R 2 is substituted phenyl and...
4692447 Tricyclic dihydropyridazinones and pharmaceutical compositions containing them  
The tricyclic dihydropyridazinone derivatives having formula I ##STR1## are endowed with interesting hypotensive, vasodilating, antiaggregant, antithrombotic and cytoprotective properties and are...
4692438 Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity  
Compounds of the formula ##STR1## wherein R 1 is hydrogen, alkanoyl or aroyl; R 2 is hydrogen or alkyl; R 3 is hydrogen or aryl; R 4 and R 5 each are hydrogen or R 4 and R 5 taken together...
4690930 Pyrazolo[4,3-c]quinoline-3-one and imidazo[4,3-c]cinnolin-3-one derivatives and their use as psychotropic agents  
Compounds of the formula (I): ##STR1## wherein R 1 and R 2 each is hydrogen, alkyl, alkoxycarbonyl, carboxy, halogen, nitro or trifluoromethyl, or R 1 and R 2 taken together may form alkylene;...
4670438 Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents  
Compounds of the formula ##STR1## wherein A, B, C and D are --N, HN, R 3 N, OC, HC.tbd., HO--C.tbd. or R 3 SO 2 --O--C.tbd.; and R 1 and R 2 are substituents of various...
4668677 4-phenylphthalazine derivatives, their preparation and their use as pharmaceuticals  
Certain new 1-alkylamino-4-phenylphthalazine derivatives, 1-neopentylamino-4-phenylphthalazine and 1-(1-ethylpropylamino)-4-phenylphthalazine, having prominent activity to ameliorate circulatory...
4663307 Anti-allergic and anti-thromboembolic 6H-dibenz-[b,e][1,4]-oxathiepin derivatives, compositions, and method of use therefor  
Novel 6H-dibenz[b,e][1,4]oxathiepin derivatives of the Formulae I and IA are employed in the treatment and control of allergic conditions such as allergic asthma. ##STR1##
4661484 Pyridazinone derivatives and salts thereof as cardiac stimulants  
There are provided novel pyridazinone derivatives having the general formula (I): ##STR1## wherein A represents 5- or 6-membered heterocyclic ring having 1-3 nitrogen atoms, which may be...
4659711 1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension  
Compounds of the general formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.
4658024 Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives  
Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R 1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl,...
4656171 2-phenyl-imidazo-pyrazines, useful as cardiotonics  
Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N or --CH, provided, however, that at least two of them must be --N, and when A and C are both --N, at...
4654344 Pharmaceutical compositions for treating ulcers containing 2-aryltetraazaindenes  
2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --NCH--CNN-- or --CHN--NCH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto,...
4652564 Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents  
Substituted spiro pyridine derivatives are anti-allergic and anti-inflammatory agents. They are also useful for the treatment of peptic ulcers. Methods for their preparation and use are disclosed.
4640920 4-(cinnolinylamino or quinazolinylamino)benzenesulphonamides and intermediates therefor  
Novel quinazoline and cinnoline derivatives having the formula ##STR1## (wherein one of A and B is CH and the other one of A and B is N; X 1 is halogen or CF 3 and X 3 is one of the groups II,...
4634701 Furan derivatives having anti-ulcer activity  
Compounds of formula (I): ##STR1## wherein: A represents a CH-NO 2 group or a N-CN group; B represents CH 2 , O, S or a direct bond; R represents a bicyclic or polycyclic residue, variously...
4632923 Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents  
Substituted heterospiro pyridine derivatives are anti-allergic and anti-inflammatory agents. They are also useful for the treatment of peptic ulcers. Methods for their preparation and use are...
4602019 Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents  
Substituted 2,5-dihydro- and 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
4591589 2-aryl pyrazolo[4,3-c]cinnolin-3-ones  
Novel pyrazolo[4,3-c]cinnolin-3-one derivatives of the formula ##STR1## wherein R may be in the 7- or 8-position and is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of...
4575505 Pharmaceutical compositions containing 2-aryltetraazaindenes for treating ulcers or cardiac insufficiency or blood pressure abnormalities  
2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --NCH--CHN-- or --CHN--NCH--, Ar is unsubstituted phenyl or phenyl mono-, di- or trisubstituted by hydroxyl, mercapto,...
4569934 Imidazo[1,2-b]pyridazines  
This invention concerns novel imidazo[1,2-b]-pyridazines and their use as agents for treating anxiety.
4565816 Piperazine derivatives and pharmaceutical composition containing them  
Piperazine derivatives or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic, anti-hypertensive or bradycardic agents.
4560688 Tricyclic antihistamines  
Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or...
4532135 Renoprotective treatments employing vasodilator compounds  
A treatment method and substances have been found to reduce the risk of incurring renal damage or failure. Vasodilators useful for the treatment of hypertension have been found to lower cholesterol...
4532248 Method of combatting coronary and vascular diseases  
1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, and R 1 to R 7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful...
4532250 5-Heteroarylimidazol-2-ones having cardiotonic activity  
Described are compounds of the formula ##STR1## wherein R is heteroaryl and R 1 is hydrogen or loweralkyl, or a pharmaceutically acceptable salt thereof. The compounds exhibit cardiotonic activity.
4526890 3,6,7,8-Substituted-s-triazolo[4,3-b]pyridazines as bronchodilators  
3,6,7,8-Substituted-s-triazolo-pyridazine compounds such as 7,8-dimethyl-6-morpholino-3-methyl-s-triazolo[4,3-b]pyridazi ne or...
4515791 Substituted phenyl-1,2,4-triazolo[2,3-b]pyridazin-3(2H)ones as anti-asthma agents  
Substituted phenyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-ones, useful as anti-asthma agents.
4505910 Amino-pyrimidine derivatives, compositions and use  
Herein is disclosed amino-pyrimidine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical...
4504484 Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use  
The substituted heteroaryl compounds of this invention are good fungicides. In particular, they possess especially good activity against Bean Powdery Mildew.
4489077 3-Isoxa-zolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides  
4-Hydroxy-N-[5-[(substituted hetero)methyl]-3-isoxazolyl]-2H-1,2-benzothiazine-3-carboxam ide 1,1-dioxides as agents for treating pain in mammals resulting from inflammation.
4485106 Substituted tetrahydrotetrazolo[5,1-a]phthalazines  
Substituted tetrahydrotetrazolo[5,1-a]phthalazine compounds such as 6-methylamino-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine are prepared by reacting a...
4478837 3-Hydrazino cycloalkyl[c]pyridazines as antihypertensive agents  
Pharmaceutical compositions comprising as the active ingredient thereof an aminopyridazine derivative of the formula: ##STR1## wherein R 1 is amino, or ##STR2## wherein each of R 3 and R 4 is...
4478822 Drug delivery system utilizing thermosetting gels  
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
4477454 2-Aryltetraazaindenes for treating cardiac insufficiency  
2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --NCH--CHN-- or --CHN--NCH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto,...
4474785 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones, and compositions for treating thermo-embolic disorders  
2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R 1 and R 2 are identical or different and each is...
4473574 Prophylaxis of arterial disease  
A method for the prophylaxis of inflammatory, degenerative or proliferative arterial disease which method comprises administering an effective amount of endralazine.
4466965 Phthalazine compounds, compositions and use  
The present invention relates to new compounds of the formula ##STR1## alkylene, or --S-- where R 1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or...
4464371 Five-membered heterocyclic compounds  
This invention relates to the compound of the general formula [I], process for preparing the compound and antihypertensive agent containing the compound as a main ingredient. ##STR1## wherein R 1 ...
4464372 Imidazo[1,2-b]pyridazines  
There are disclosed herein certain substituted imidazo[1,2-b]pyridazine compounds which are useful in the treatment of peptic ulcer diseases.
RE31623 Pesticidal cinnolines  
Use of certain cinnolines as pesticides and pesticidal compositions containing them.
4438128 Cardioactive aryloxypropanolamines  
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 , which may be the same or different, are hydrogen or halogen atoms or lower...
4432978 Hexahydro-trans-pyridoindole  
Derivatives of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]-indole and of (+)enantiomeric, mixtures of (+) and (-)enantiomeric or (±)racemic 2,3,4,4a,5,9b-hexahydro-4a,9b-trans-1H-pyrido[4,3-b]indole,...
4406879 Phthalazinol preparation  
The present invention relates to a pharmaceutical composition containing (1) 6,8-dimethyl-7-ethoxycarbonyl-4-hydroxymethyl-1-phthalazone, (2) a water-soluble cellulose ether alone or together with...
Matches 601 - 650 out of 712 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >