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4963550 |
Substituted thioureas, isothioureas and carbodiimides and use as pesticide
The invention relates to novel substituted N-phenylthioureas, N-phenylisothioureas and N-phenylcarbodiimides of formula ##STR1## wherein R 1 to R 5 and Z are as defined in the specification. The...
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4960775 |
Pyrrolophthalazines
Therapeutically useful pyrrolo[2,1-a]phthalazine derivatives of the formula: ##STR1## wherein R 1 and R 2 represent cycloalkyl, optionally substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl,...
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4956369 |
2-dithioalkyl-dihydropyridines and pharmaceutical compositions containing them
Compounds of formula I ##STR1## wherein R 1 and R 3 , which are the same or different, are alkoxycarbonyl, acetyl, cyano, nitro, benzoyl or amino-carbonyl groups, R 2 is differently...
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4948796 |
Piperazine derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient
A piperazine derivative represented by the following formula or a salt thereof: ##STR1## which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.
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4939140 |
Heterocyclic oxophthalazinyl acetic acids
A heterocyclic oxophthalazinyl acetic acid having aldose reductast inhibitory activity of the formula ##STR1## wherein X is oxygen or sulfur; Z is a covalent bond, O, S, NH or CH 2 or CHR 5 Z is...
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4937255 |
Disubstituted pyrroles
For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R 1 is aryl or heteroaryl, R 2 is...
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4925844 |
Antagonizing the pharmacological effects of a benzodiazepine receptor agonist
The invention relates to a method of using a compound of formula Ia ##STR1## to antagonize the effects of benzodiazepine receptor agonists.
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4925843 |
2-pyridylmethylthio derivatives as antiulcer agents
2-Pyridylmethylthio derivatives of formula (I) are provided. ##STR1## wherein A represents 4-methyl-2-quinazolinyl, 4-(2-pyridylmethylthio)-1-phthalazinyl or...
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4914098 |
Substituted thioureas, isothioureas and carbodiimides and their use as pesticides
Substituted N-phenylthioureas, N-phenylisothioureas and N-phenylcarbodiimides of formula ##STR1## wherein R 1 is C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl, polycyclic alkyl containing a total of 7...
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4910022 |
Phthalazineacetic acid composition and tablet
A tablet composition for a phthalazineacetic acid compound to be employed in treating clinical effects associated with diabetes is described. The composition permits formation of tablets having a...
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4910199 |
Imidazo[1,2-]pyridazines for cortical cholinergic deficiencies
The present invention relates to imidazo[1,2-b]-pyridazines having the formula: ##STR1## in which: R 1 represents hydrogen, a halogen atom, a C 1 -C 4 alkoxy group or a C 1 -C 4 alkyl group...
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4895843 |
Use of 3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid as a hypouricaemic agent
The invention concerns a novel therapeutic agent for use in reducing raised serum uric acid levels comprising 3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid or a pharmaceutically...
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4892873 |
N-substituted -N-(3-(1,2,4-triazolo-(4,3-b)pyridazin-6-yl)phenyl)alkanamides, carbamates and ureas
Novel organic compounds which are N-substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phen
yl]alkanamdies , carbamates and ureas which are useful as anxiolytic or antiepileptic agents, methods...
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4889852 |
Anxiolytically active piperazine derivatives
It has been found that a group of piperazine derivatives known to have blood-pressure lowering properties possess good anxiolytic properties. In two well known animal test models the compounds are...
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4886800 |
Substituted cinnoline derivatives as CNS depressants
The present invention comprises certain amide and ester derivatives of 4-substituted-cinnoline-3-carboxylic acids and 3-acyl-4-substituted-cinnoline derivatives, and their use as central nervous...
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4883794 |
Pyrrolo(1,2-b)cinnolines
There are described pyrrolo[1,2-b] cinnolines having formula ##STR1## where R 1 when present is hydrogen, loweralky, arylloweralkyl or --CH 2 CO 2 C 2 H 5 ; is hydrogen, loweralkyl,...
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4880805 |
Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R 6 and R 7 are hydrogen or...
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4873243 |
Derivatives of 3-imino-pyridazine, process for obtaining them and pharmaceutical compositions containing them
The invention relates to derivatives of 2,3-dihydro 3-imino-pyridazine responding to general formula: ##STR1## in which: A represents an atom of oxygen or of sulfur; R 1 represents a lower...
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4868179 |
Method of reducing mortality associated with congestive heart failure using hydralazine and isosorbide dinitrate
A method of reducing mortality associated with chronic congestive heart failure in a patient with impaired cardiac function and concomitant reduced exercise tolerance, comprising the oral...
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4866059 |
'(2S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4 -b)pyrazin-7-yl)-carbamic acid, ethyl ester
The (2S)-(-)-isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7
-yl)arbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(±)-...
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4863948 |
Isoindolinone sulfonamide anti-arrhythmic agents
A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkyl
amine derivatives have been prepared, including their pharmaceutically acceptable salts, wherein the heterocyclic...
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4863945 |
Pyrrolobenzimidazoles and pharmaceutical compositions containing them
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R 1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered...
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4861778 |
2,3-dihydrophthalazine-1,4-diones
A compound having the structural formula ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 carbalkoxyalkyl or phenyl substituted with C 1 -C 3 alkyl or halogen; R 2 is hydrogen or...
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4849421 |
Anti-anxiety benzothiepino(5,4-c]pyridazines
A benzothiepino 5,4-c]pyridazine compound of the formula: ##STR1## wherein R 1 and R 2 are the same or different and each is hydrogen, halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C 1...
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4847251 |
Pyridazinone derivatives, and pharmaceutical compositions containing them
The present invention provides pyridazinone derivatives of the general formula: ##STR1## wherein Het is a mono- or bicyclic heterocycle with one or two nitrogen atoms, B-C is a --CHR 1 --CH 2 --,...
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RE32975 |
4-Pyridone-3-carboxylic acids and/or derivatives thereof
The invention provides 4-pyridone-3-carboxylic acids and derivatives thereof together with a method for their preparation. Also included in the invention are compositions containing said...
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4843075 |
Benzothiopyrano[4,3-c]pyridazine compounds, methods for preparing said compounds and uses of said compounds
A benzothiopyrano[4,3-c]pyridazine compound of the formula: ##STR1## wherein R 1 and R 2 are the same or different and each is hydrogen, halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C...
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4831034 |
4-benzylpiperazines useful as neuroleptics
Compounds of formula (I) in which the broken line forms a phenyl, naphthyl, pyridyl, indolizine, pyrrolo[1,2-a]pyrazine, pyrrolo[1,2-a]pyrimidine or pyrrolo[1,2-c]pyrimidine ring-system, R=H,...
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4831029 |
Condensed cyclic triazole derivatives, pharmaceutical compositions and use
The invention relates to condensed cyclic triazole derivatives of the general Formula I ##STR1## and pharmaceutically acceptable salts thereof. The compounds of the general Formula I possess useful...
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4826837 |
Cinnoline-carboxamides and process for their preparation
The invention relates to compounds having the general formula (I) ##STR1## wherein n is zero, 1 or 2; each of R 1 and R 2 is independently: (a) hydrogen, halogen, trifluoromethyl or C 1 -C...
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4824849 |
α.sub.2 -adrenoceptor antagonistic arylquinolizines
Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective α 2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives,...
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4810705 |
Triazolo [3,4-b]pyridazines, process for their preparation and pharmaceutical compositions containing them
The invention relates to 1,2,4-triazolo [4,3-b]pyridazines substituted in the 7-position of formula: ##STR1## in which R represents hydrogen, a lower alkyl group, a phenyl group, a chlorophenyl...
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4806535 |
Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility
This invention relates to imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds of the formula ##STR1## wherein A is CH or N and not more than one of W, X, Y...
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4801587 |
Impotence ointment
An ointment for relieving impotence. The ointment generally consists of a primary agent, a carrier, and a base, and is applied directly to the penis. The primary agent is a vasodilator selected...
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4788186 |
6-substituted-s-triazolo[3,4-a]phthalazine derivatives
The present invention refers to new s-triazolo[3,4-a]phthalazine derivatives, to the process for their preparation and to the pharmaceutical compositions containing them.
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4783461 |
3,6-disubstituted triazolo [3,4-A]phthalazine derivatives
The present invention is directed to new 3,6-disubstituted-1,2,4-triazolo[3,4-a]phthalazine derivatives of formula I ##STR1## wherein R represents phenyl or substituted phenyl, n is 1 or 2, R 1 is...
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4782057 |
Benzo[h]cinnoline compound, a method of preparing said compound and a pharmaceutical composition
A benzo[h]cinnoline compound of the formula: ##STR1## wherein each of X and Y is hydrogen, halogen, trifluoromethyl, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms,...
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4775524 |
Method of treating hyperproliferative skin disease with substituted heterospiro pyridine derivatives
A method of treating a mammal for hyperproliferative skin disease is disclosed, using substituted heterospiro pyridine derivatives.
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4772598 |
2-aryl-3,4-diazabicyclo(4.n.O)alk-2-en-5-ones for the preparation of an agent for treating cardiac insufficiency
2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R 1 , R 2 and R 3 have the stated meanings, are used for the treatment of cardiac insufficiency.
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4769236 |
Medicaments with a high degree of solubility and method for their production
The present invention relates to medicaments with a high degree of dissolution rate and solubility. These medicaments are characterized in that they are in amorphous form produced by spraying in...
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4769369 |
Anti-allergy 1(2H)-phthalazinones
Novel 1 2(H)-phthalazones are disclosed along with a method of treating either allergic rihinitis or bronchial asthma by the administration to a mammal an effective amount of a compound of the...
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4764512 |
Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses
This invention relates to substituted benzodiazinone-pyridone compounds and their use as cardiotonic agents including methods for increasing cardiac contractility, pharmaceutical compositions...
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4764518 |
Antibacterial agents containing oxo-4-pyridine carboxylic acid derivatives
The present invention relates to novel antibacterial agents, corresponding to the following general formula I ##STR1## in which: Q represents an aromatic ring, X represents a hydrogen atom or a...
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4755511 |
Tricyclic pyridazinone compounds
This invention relates to tricyclic pyridazinone compounds, pharmaceutical compositions containing the compounds, and a method of stimulating cardiac activity in a mammal by administering an...
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4753940 |
Barbituric acid derivatives
The invention relates to novel phenylcarbamoylbarbituric acid derivatives of the general formula ##STR1## wherein R 1 is C 1 -C 4 alkyl, C 1 -C 3 alkoxy, allyl or C 3 -C 6 cycloalkyl, R 2...
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4751224 |
Treatment of metastasis
A method for reducing the incidence of metastasis in tumor victims without treating the primary tumor per se resides in the administration of forskolin or its analogs which are potent inhibitors of...
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4749701 |
Aminostyryl compound, leukotriene antagonistic composition containing the same as effective ingredients and method of antagonizing SRS by employing the same
Disclosed are an aminostyryl compound represented by Formula I: ##STR1## wherein A represents a linking group having 3 to 4 chain members; B represents an unsubstituted or substituted 5 to...
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4746658 |
2-phenyl-imidazo-pyrazines, -pyridazines and -triazines
Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N or --CH, provided, however, that at least two of them must be --N, and when A and C are both --N, at...
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4734415 |
Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as...
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4732898 |
2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and...
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