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7618969 |
Compounds which potentiate glutamate receptor and uses thereof in medicine
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed:
wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
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7612068 |
Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives
The present invention relates to compounds of formula I wherein the substituents are as defined below. The compounds of formula I are useful for the treatment of diseases such as schizophrenia,...
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7608621 |
N-substituted glycine derivatives: hydroxylase inhibitors
The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I)
which are antagonists of HIF prolyl hydroxylases and are useful for treating...
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7605289 |
Benzamide derivatives and uses related thereto
Benzamide derivatives of formula I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described...
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7605261 |
Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use
The invention relates to new products of formula (I):
in which: Y represents oxygen or sulphur, Z represents C═CH2, CH—CH3 or CH2, R1 represents hydrogen, morpholinyl or the
radical. In...
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7601715 |
Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a...
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7598247 |
Immunomodulating heterocyclic compounds
Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy:
wherein R 1 and R 3 independently represent H; F; Cl; Br; —NO 2 ; —CN; C 1 -C 6 alkyl optionally...
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7595317 |
Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases
The present application describes novel barbituric acid derivatives of formula I:
or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R 1 , R 2 , R 3 , R 4 , R 5 , n,...
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7595316 |
Heteroaryloxy nitrogenous saturated heterocyclic derivative
Compound of the formula: (I) [wherein each of X 1 , X 2 and X 3 independently represents N or CH, W represents the formula (II):(II) or the formula (III):(III) and Y represents a group of the...
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7585887 |
Active agent combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing
(a) cyclic ketoenols having the formula
in which the groups...
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7579350 |
Scaffolds for α-helix mimicry
Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated...
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7572798 |
Combi-molecules having signal transduction inhibitory properties and DNA damaging properties
The present invention relates to a series of new chemical agents that demonstrate anti-tumor activity. More particularly, the present invention relates to molecules, referred to as...
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7572793 |
3-Substituted-4-pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:
wherein R 1 represents...
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7563790 |
Pyridazine derivatives
Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid arthritis,...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7553835 |
Topical antifungal composition
The subject matter relates to a topical, foamable composition including at least one antifungal agent, said composition characterised in that said at least one antifungal agent is able to penetrate...
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7550461 |
Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases
Disclosed are amide compounds of formula (I):
wherein Ar 1 , Q, Y and R 3 -R 6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory...
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7547697 |
Alkyl-pyridazine derivatives as 11b-HSD1 inhibitors
Compounds of formula (I):
as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.
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7544684 |
Hydrazono-malonitriles
Hydrazono-malonitrile derivatives of the formula (I) in which R 1 , R 2 , R 3 , R 3′ and R 4 have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for...
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7534795 |
Compounds and their use related to compositions for treating disease
Novel compounds and their uses are disclosed herein.
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7521451 |
Isoindoline derivative
Provided is a novel isoindoline compound of the formula (I):
The compound is useful for anesthesia by inducing sedation in a mammal.
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7517994 |
Heterocyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification....
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7514446 |
Pyrimidine compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7514406 |
Methods for inhibiting deacetylase activity
A method for identifying a compound that inhibits the NAD + -dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other...
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7511038 |
Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors
New pyridazin-e-(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and...
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7504397 |
mTOR inhibitor compounds
Compounds of formula I:
A-B-C (I)
and isomers, salts, solvates, chemically...
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7491720 |
Aminopyridine derivatives having Aurora A selective inhibitory action
The present invention relates to a compound represented by the general formula (I):
wherein m 1 and m 2 are 1, 2, or 3; n 1 and n 2 are 0 or 1; i is an integer of any of 1 to m 1 ; j is an...
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7485643 |
Bicyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 20 , R 21 , and R 22 are as defined in...
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7485642 |
Method for treating septic shock
Levosimendan, or (−)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)p
henyl]hydrazono]propanedinitrile, which has been mentioned for the treatment of congestive heart failure, is useful in...
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7479492 |
Use combined 5-HT1A agonists and selective serotonin reuptake inhibitors
The present invention relates to the use of compounds being combined selective serotonin (5-HT) reuptake inhibitors (SSRIs) and 5-HT 1A receptor agonists, in particular of...
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7470687 |
Aryl oximes
Aryl oxime derivatives of the formula (I), in which R 1 , R 2 , R 3 , X and B are as defined in Claim 1 , act as phosphodiesterase IV inhibitors and can be employed for the treatment of...
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7468437 |
Phenyl pyrrolidine ether tachykinin receptor antagonists
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
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7465734 |
Methods and compositions for overcoming resistance to biologic and chemotherapy
This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous,...
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7459453 |
Pyridazin-3(2H)-one derivatives as PDE4 inhibitors
New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and...
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7456185 |
Substituted quinazoline compounds useful as p38 kinase inhibitors
Compounds having the formula (I),
are useful as p38 kinase inhibitors, wherein R 4 and R 5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R 6 and R 7 are...
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7452882 |
Thyroid hormone analogs
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
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7449446 |
Combination product comprising melagatran and dexamethasone
There is provided a combination product comprising; (A) melagatran or a pharmaceutically acceptable derivative thereof; and (B) dexamethasone or a pharmaceutically acceptable derivative there of,...
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7442369 |
Compositions of minoxidil
Novel compositions comprising minoxidil, a thickening agent, and a pharmaceutically acceptable solvent are presented. Also presented is a process for making a novel gel composition comprising...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7439268 |
Compositions containing prodrugs of florfenicol and methods of use
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one...
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7432261 |
Anti-inflammatory phosphonate compounds
The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as...
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7429599 |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
This invention generally relates to methods for treating or preventing a condition responsive to JNK inhibition, such as a metabolic condition, comprising administering to a patient in need thereof...
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7425559 |
Medicine containing pyrimidine derivative
A medicine for central diseases which contains as the active ingredient either a compound represented by the general formula (I): (I) (wherein R 1 represents hydrogen or C 1-6 alkyl; R 2 ...
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7425532 |
Use of alanyl aminopeptidase inhibitors and pharmaceutical compositions containing said inhibitors
The present invention relates to the use of one inhibitor or of several inhibitors of alanyl aminopeptidases and/or of enzymes having a similar substrate specificity for the induction of the...
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7417043 |
Modulators of dopamine neurotransmission
A 3-substituted 4-(phenyl-N-alkyl)-piperazine compound of the following formula:
wherein R 1 is selected from the group consisting of OSO 2 CF 3 , OSO 2 CH 3 , SO 2 R 3 , COCF 3 , COCH 3 and...
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7405214 |
Nucleoside derivatives and therapeutic use thereof
The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions...
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7399762 |
Opioid receptor agonist compounds and their use in treatment of pain
Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.
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7384942 |
Pyrazine based inhibitors of glycogen synthase kinase 3
New bicyclic based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The...
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7371743 |
Carboxylic acid amides, the preparation thereof and their use as medicaments
The present invention relates to new substituted carboxylic acid amides of general formula
wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the...
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7341749 |
Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer
A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia)...
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