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7622469 |
2,4-diamino-1,3,5-triazine derivatives
The present invention relates to an antibacterial agent, which comprises, as an active ingredient, a compound represented by the following general formula (1):
or a pharmaceutically acceptable...
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7618968 |
Aryl triazines as LPAAT-β inhibitors and uses thereof
The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
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7608620 |
LPAAT-β inhibitors and uses thereof
The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using...
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7608618 |
Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1
Compounds of the formula
wherein: Y′ is O or S, W′ is
optionally substituted,
Z′ is selected from the group consisting of
wherein Q′ is OR 7 and R 7 is C 1-3 alkyleneC 3-8...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7592451 |
Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments
The present invention relates to a compound having the formula
where Z is an amine, phenoxy, or thiol-containing group, and Y is an alkyl-containing amine. Methods of producing such compounds...
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7589092 |
Prodrugs of heteroaryl compounds
The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
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7579465 |
Antiviral agents
This invention relates to compounds of formula I
their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the...
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7566712 |
Biaryl piperazinyl-pyridine analogues
Biaryl piperazinyl-pyridine analogues are provided, of the Formula:
wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity...
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7560450 |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted xanthines of general formula
the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable...
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7534421 |
s-Triazine compounds bearing at least one para-aminobenzalmalonic salt substituent and photoprotective cosmetic compositions comprised thereof
Stable, topically applicable cosmetic/dermatological sunscreen compositions, well suited for the UV-photoprotection of human skin/keratinous materials, contain a thus effective amount of at least...
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7524874 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7514442 |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7507734 |
Pyridazinone derivatives
Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R 1 and R 2 are detailed in the description, as well as their physiologically acceptable...
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7501511 |
Process for resolving aimines that are useful for the treatment of disorders associated with insulin resistance syndrome
The present invention is directed towards a process for resolving a racemic amino compound derived from dihydro-1,3,5-triazines. The invention is also directed towards the enantiomers of amino...
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7485654 |
Corneal perception recovery drug containing amide compound
The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal...
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7485641 |
Substituted 3-amino-pyrrolidino-4-lactams
The invention provides compounds of formula (1),
and the pharmaceutically acceptable salt thereof, wherein R 1 , n and R 2 are as described herein; compositions thereof; and uses thereof.
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7470695 |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7462617 |
Substituted acylpiperazine derivatives
The invention relates to compounds of formula
wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof.
The invention further...
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7452883 |
Dihydro-1,3,5-triazine amine derivatives and their therapeutic uses
The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4, R5 and R6 are as defined in Claim 1 . The compounds are useful in the treatment of pathologies related to the...
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7425451 |
Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
Compounds, compositions, methods for sequencing proteins and peptides, and methods for identifying proteins and peptides in a mixture, are disclosed. Compounds of formula A-B-C wherein A is a...
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7371398 |
Bovine teat cleaning process using dry powder reagents
Animals have been domesticated and kept as a source of milk for tens of thousands of years. When humans keep animals for their ability to produce milk, the animals are usually kept in confined...
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7344727 |
Process for cleaning bovine teats
Animals have been domesticated and kept as a source of milk for tens of thousands of years, When humans keep animals for their ability to produce milk, the animals are usually kept in confined...
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7335672 |
Vanilloid receptor ligands and their use in treatments
Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache,...
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7319099 |
Benzoyl-piperazine derivatives
The invention relates to compounds of formula
wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such...
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7307079 |
1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors
The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-A 3 receptors, as well as to pharmaceutical compositions containing a pharmacologically active...
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7291616 |
Aryl triazines as LPAAT-β inhibitors and uses thereof
The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
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7285550 |
Triazolotriazines and pyrazolotriazines and methods of making and using the same
The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A 2a adenosine receptor, and can be useful as antagonists thereof for preventing...
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7244732 |
Prodrugs of heteroaryl compounds
The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
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7223759 |
Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7205298 |
Substituted triazine kinase inhibitors
The present invention provides substituted 1,3,5-triazine compounds as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder.
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7205302 |
Heterocyclic compound derivatives and medicines
The present invention provides a compound which is useful as a PGI 2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition...
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7173038 |
Quinazoline derivatives as VEGF inhibitors
The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R 1 represents halogeno or C 1-3 alkyl; X 1 represents —O—; R 2 is selected from one of...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7132423 |
Methods and compositions of novel triazine compounds
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is...
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7132448 |
High concentration topical insecticide containing insect growth regulator
A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an...
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7084138 |
Active ingredient combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing
(a) cyclic ketoenols having the formula
in which the groups...
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7045495 |
Combination of bryostatin and paclitaxel for treating cancer
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
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7008903 |
Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I)
wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active...
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7001903 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures of spinosyns and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests.
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6984662 |
High concentration topical insecticide containing insect growth regulator
A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an...
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6953798 |
β-alanine derivates
Alkanoic acid derivatives of formula (1) are described:
Ar 1 (Alk a ) r L 1 Ar 2 CH(R 1 )C(R a )(R a′ )R (1)
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6949544 |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
The present invention provide a compound of formula I or II:
or a pharmaceutically acceptable derivative thereof, wherein R 1 , R 2 , R 3 , and R 4 are as described in the specification....
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6919339 |
ABCA-1 elevating compounds
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in...
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6894047 |
Triazine compounds useful as sorbitol dehydrogenase inhibitors
This invention is directed to sorbitol dehydrogenase inhibitory compounds of formula I
wherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to...
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6887873 |
Triazine derivatives and their application as antitelomerase agents
The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their...
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6864256 |
Methods for the control of insect pests
The present invention provides methods for the control of insect pests in the vicinity of feces or manure of a domestic animal. Such methods comprise orally administering cyromazine, wherein said...
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6852717 |
Compounds useful as anti-inflammatory agents
Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6815459 |
Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
The present invention provides novel seleno compounds containing nitrone moiety, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing...
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