Matches 251 - 300 out of 340 < 1 2 3 4 5 6 7 >
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4873242 2,4-diamino-6-substituted-phenyl-S-triazines as nootropic agents  
Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof wherein R 1 is hydrogen or lower alkyl and R 2 and R 3 are the same or different and each is hydrogen, lower...
4863938 Pyridine derivatives and their use as nootropic agents  
Pyridine derivatives of the formula ##STR1## their tautomers and their salts, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the meanings given in the claims, can be used as active ingredients in...
4863945 Pyrrolobenzimidazoles and pharmaceutical compositions containing them  
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R 1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered...
4859669 Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones  
Tricyclic pyrrolo naphthyridinone compounds and tricyclic pyrrolo pyrido pyrazines are disclosed, which are useful as antiinflammatory and anti-hyperproliferative agents.
4851406 Heterocyclic-substituted indoles and pharmaceutical compositions containing them  
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
4851411 5-monoaryl as.-triazin-3-ones substituted in 2-position, and their use as medicaments  
The present invention concerns new 5-monoaryl as.-triazin-3-ones substituted in 2-position, a method of preparing them, and their use as medicaments. The compounds according to the present...
4847249 Triazine salt  
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate is provided. This salt has high water solubility and thus advantageously allows parenteral administration in the form of a sterile...
4803206 Antihypertensive acylpyrazines  
Acylpyrazines useful in the treatment of hypertension are disclosed.
4792547 Pyrazine-2-carboxamide derivatives useful in treating allergic disease  
Novel pyrazine derivatives useful for treatment of bronchial asthma, allergic gastorenteric trouble, hay fever urticaria, allertic rhinitis, and allergic conjunctivitis, and pharmaceutical...
4788194 Heterocyclic compounds  
Heterocyclic compounds of the formula ##STR1## wherein A is a direct link, or is alkylene of 1 to 4 carbon atoms or alkenylene of 2 to 4 carbon atoms; wherein either X is --CR 1 R 2 -- and Y is...
4786644 1-aryl-3-quinolinecarboxamide  
Novel 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides, processes for the preparation thereof, and methods for treating pain and inflammation utilizing compounds and...
4786639 Method for the treatment of reversible airways obstruction and asthma  
A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective...
4782056 2-phenylhexahydro-1,2,4-triazine-3-,5-diones  
Compounds of the formula I ##STR1## with n=1-3, R=H, Hal, CF 3 , alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino,...
4782055 Imidazopyridine compounds useful in the treatment of ulcers  
The present invention relates to imidazopyridine compounds of the formula: ##STR1## wherein R 1 is lower alkynyl or lower alkynyloxy(lower)-alkyl, R 2 is lower alkyl, and R 3 is...
4782067 Anti-allergic composition containing zwitterionic bicyclic compounds  
Zwitterionic bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents and in the treatment of hyperproliferative skin disease....
4782083 3,4-dihydro-2H-1-benzopyrans useful as anti-hypertensive agents  
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: one of R 1 and R 2 is hydrogen or C 1 -4 alkyl and the other is C 1 -4 alkyl or R 1 and R 2 together...
4772603 Method for treating congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals  
A method for the treatment and/or prophylaxis of congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals, such as humans, which method...
4767760 Anti-protozoal 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione derivatives, compositions, and method of use therefor  
Novel 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones which are effective in destroying or preventing the growth of Protozoa in subjects suffering from such Protozoa.
4764527 Hydroxypyrazole derivatives, composition containing them and their use against microorganisms  
1-Hydroxypyrazoles of the formula ##STR1## where R 1 , R 2 and R 3 independently of one another are each hydrogen or halogen, and microbicides containing these compounds.
4753940 Barbituric acid derivatives  
The invention relates to novel phenylcarbamoylbarbituric acid derivatives of the general formula ##STR1## wherein R 1 is C 1 -C 4 alkyl, C 1 -C 3 alkoxy, allyl or C 3 -C 6 cycloalkyl, R 2...
4738963 Method for the treatment of incontinence in mammals  
A method for the treatment and/or prophylaxis of incontinence in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula...
4725596 Pyrimidine derivatives having anti-allergy, anti-inflammatory and immuno suppressant activity  
Certain pyrimidine derivatives are useful in treating allergic, inflammatory and hyperproliferative skin diseases and in suppressing the immune response. Methods for preparing the compounds and...
4713381 Oxodiazine compounds and pharmaceutical compositions thereof  
An oxodiazine compound of the formula: ##STR1## or a pharamceutically acceptable acid addition salt thereof, wherein each of R 1 and R 2 is hydrogen, halogen, C 1 -4 alkyl, C 1 -4 alkoxy, C 1 -4...
4710498 Pyridyloxy derivatives  
Pyridyloxy derivatives represented by the general formula: ##STR1## wherein the substituted group Z is either one of the following groups: ##STR2## were prepared. These derivatives exert antagonism...
4698352 4-oxo-1,4-dihydronicotinic acid derivatives, salts thereof, and antibacterial agents containing the same  
This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R 1 is hydrogen or carboxyl-protecting group; R 2 is substituted phenyl and...
4683228 Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion  
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
4677105 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics  
2-Alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-Triazines of the formula I ##STR1## wherein R and R 1 , which may be identical or different, represent hydrogen, alkyl, alkoxy, hydroxy, dialkylamino, or...
4661484 Pyridazinone derivatives and salts thereof as cardiac stimulants  
There are provided novel pyridazinone derivatives having the general formula (I): ##STR1## wherein A represents 5- or 6-membered heterocyclic ring having 1-3 nitrogen atoms, which may be...
4652564 Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents  
Substituted spiro pyridine derivatives are anti-allergic and anti-inflammatory agents. They are also useful for the treatment of peptic ulcers. Methods for their preparation and use are disclosed.
4649139 1,2,4-triazines  
Compounds of Formula I are novel and useful as cardiovascular agents, particularly anti-arrhythmic agents: ##STR1## or the 5-imino-tautomer thereof or a salt of either, wherein R 1 is C 1 -10...
4640917 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones  
Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula ##STR1## in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen,...
4631278 Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneace tonitrile derivatives, pharmaceutical compositions, and method of use therefor  
The present invention is related with α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benz eneaceton itriles which are effective in destructing or preventing the growth of Protozoa in...
4618610 Triazine derivatives, and pharmaceutical compositions comprising the same  
New triazine derivatives represented by the formula: ##STR1## wherein R 1 is hydrogen or halogen; R 2 is a hydroxy, protected hydroxy, amino, cyano, mercapto, lower alkylthio, arylthio,...
4616002 Dihydro pyridine compounds, compositions and use  
Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR...
4613603 Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in which they are present  
The invention relates to compounds with a nitrogen-containing heterocyclic nucleus, of the general formula: ##STR1## in which: Ar represents a group ##STR2## or a naphthyl group optionally...
4602017 Substituted aromatic compounds  
The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R 6 is chlorine, bromine, iodine, C 1 -4 alkyl or trifluoromethyl, or R 6 and R 7...
4599336 Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide  
Compounds of the formula ##STR1## wherein R 1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C 1 -C 7 )...
4593039 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols  
1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have β-adrenergic blocking activity with some cardioselectivity and hence are useful as...
4584298 Triazinones  
Heterocyclic compounds of the formula ##STR1## wherein either X is --CR 1 R 2 and Y is --O--, --S-- or --NR 3 --, wherein R 1 , R 2 and R 3 , which may be the same or different, each is...
4582836 Octahydroindolizine compounds useful as analgesics  
Octahydroindolizidines of the formula (I): ##STR1## where A is a 3-7 carbon or hetero-containing ring, R 1 is a substituent and x is 0-3. Also, pharmaceutical composition for treating pain and...
4579856 Fungicidal N-pyridyloxyalkyl amides  
Compounds of the formula: ##STR1## wherein X is oxygen or sulfur; Z is oxygen or sulfur; R is pyridyl optionally substituted with 1 to 3 substituents independently selected from halogen, lower...
4578386 7,8-Dihydroimidazo[1,5-a]pyrazin-8-ones  
Provided are compounds of the structure: ##STR1## wherein R 1 , R 3 , R 5 and R 6 are independently H, alkyl, aralkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl,...
4571397 Pyridazinone derivatives, preparation thereof, and agricultural and horticultural fungicidal, insecticidal, acaricidal, nematicidal compositions containing said derivatives  
Novel 5-substituted -3(2H)-pyridazinone derivatives and preparation thereof are provided. The derivatives have the formula: ##STR1## wherein, R denotes an alkyl, R 1 and R 2 denote each...
4563456 1,2,4-Triazines for treating gastrointestinal motility dysfunction  
Method for treating gastrointestinal motility dysfunctions using 1,2,4-triazines.
4560687 Substituted aromatic compounds  
The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R 6 , R 7 , R 9 and R 10 are each hydrogen, halogen, C 1 -4 alkyl or...
4560738 Pest-combating agent having increased duration of action  
A novel pest-combating agent of increased duration of action is produced by reacting a pest-combating agent having at least one hydrogen atom active in a Zerewitinoff reaction other than a hydrogen...
4551460 Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis  
Pyrido[2,1-b]quinazoline derivatives of the formulas ##STR1## wherein R 1 , R 2 and R 3 are as hereinafter set forth, are described. The compounds of formulas I and II are useful as agents for...
4511566 2-N-Cycloalkylmethyl 3-oxo 5,6-diaryl-as-triazines  
The present invention concerns new 2-N-cycloalkylmethyl 3-oxo 5,6-diaryl as-triazines, their method of production, pharmaceutical compositions thereof, and their use as medicaments, for treating...
4503054 6-Aryl-1,2,4-triazin-6-ones which possess cardiotonic properties  
Novel heterocyclic compounds of the formula: ##STR1## wherein either X is --CR 1 R 2 -- and Y is oxygen, sulphur or --NR 3 --, wherein R 1 , R 2 and R 3 , which may be the same or different,...
4495185 1,2,4-Triazin-3(2H) ones  
Heterocyclic compounds of the formula ##STR1## wherein either X is --CR 1 R 2 and Y is --O--, --S-- or --NR 3 --, wherein R 1 , R 2 and R 3 , which may be the same or different, each is...
Matches 251 - 300 out of 340 < 1 2 3 4 5 6 7 >