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6794398 |
Preventive/remedies for liver diseases
The invention provides an agent for the prophylaxis and treatment of liver disease and an activation inhibitor of hepatic stellate cells, which contains a compound having a Rho kinase inhibitory...
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6787561 |
Benzimidazole compounds
A benzimidazole compound or a salt thereof which has an inhibitory action of forming of macrophages and is useful as an active ingredient of an orally available medicament for preventive and/or...
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6784176 |
Solvates of pymetrozine
Compounds of formula wherein r and s, independently of each other, signify any value between 0.00 and 12.00; and L is methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol,...
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6774127 |
Pyrazole and pyrazoline substituted compounds
Novel pyridyl and pyrimidinyl substituted pyrazole and pyrazoline compounds and compositions for use in therapy.
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6770645 |
Pharmaceutically active compounds
Compound of general formula I: wherein R 1 , R 2 , R 3 , R 4 , X, Y and R 5 have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for...
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6770269 |
Cosmetic and dermatological light-protective formulations containing triazine derivatives and one or several esters of unbranched-chain carboxylic acids and branched-chain alcohols
Active ingredient combinations comprising tris(2-ethylhexyl) 4,4′,4″-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate
and one or more esters of unbranched-chain carboxylic acids and...
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6750235 |
Pramipexole as a treatment for cocaine craving
Disclosed herein are methods foe reducing stimulant dependency or craving, involving administration of a therapeutically-effective amount of a dopamine agonist, such as pramipexole.
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6730672 |
Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
The invention concerns compounds of formula (I) wherein each of G 1 , G 2 and G 3 is CH or N; m is 1 or 2; R 1 includes hydrogen, halogeno and (1-4C)alkyl; M 1 is a group of the formula: NR...
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6723720 |
Pesticidal triazine-derivatives
A compound of formula wherein R 1 is unsubstituted or substituted aryl or heteroaryl, the substituents of the aryl and heteroaryl rings being selected, for example, from the group consisting of...
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6720341 |
Preventives/remedies for kidney diseases
A compound having a Rho kinase inhibitory activity, such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)-cyclohexan
e, has a renal interstitial fibrosis inhibitory action in renal interstitial...
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6696459 |
Steroid receptor modulator compounds and methods
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
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6683080 |
Treatment of diabetes mellitus
Use of vardenafil or a pharmaceutical composition thereof in the preparation of a medicament for the curative, palliative or prophylactic treatment of type 2 diabetes mellitus.
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6677339 |
Phenylalanine derivatives
Phenylalanine derivatives of formula (1) are described: in which: Ar 1 is an aromatic or heteroaromatic group; L 1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar...
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6673795 |
Pyrimidine, pyrazine and triazane derivatives
The present invention is a pyrimidine, triazine or pyrazine derivative of the formula or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined in...
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6656951 |
8-aza-bicyclo&lsqb 3.2.1&rsqb octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
Compounds of the formula: are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and also...
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6653309 |
Inhibitors of IMPDH enzyme technical field of the invention
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
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6653311 |
5-lipoxygenase inhibitors: (2-azinylamino) quinone derivatives
We have synthesized a series of new derivatives of (2-azinylamino) quinone, that have the general formula shown below. Several compounds of this new series of derivatives have been shown to be...
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6649631 |
Compositions and methods for treating bone deficit conditions
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic...
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6649649 |
Method of treating colonic adenomas
This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a...
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6638938 |
Method for preventing tissue injury from hypoxia
There is disclosed a method for preventing tissue injury caused by tissue hypoxia and reoxygenation, comprising administering a compound that inhibits signal transduction by inhibiting cellular...
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6602889 |
5-heteroaryl substituted indoles
The present invention relates to compounds having general formula (I) as defined herein, or a pharmaceutically acceptable acid addition salt thereof. The compounds are selective α 1 -adrenoceptor...
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6593328 |
Pesticides
Compounds of formula (I) or pesticidally acceptable salts thereof, compositions containing them and methods of use.
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6586433 |
Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6579878 |
Pharmaceutical compositions and methods for use
Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and...
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6576632 |
Biaryl compounds useful as anticancer agents
The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 10 , R 11 , b, m, n, p...
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6573262 |
Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.
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6552031 |
Synergistic analgesic combination of oxycodone and rofecoxib
Disclosed is a pharmaceutical composition, comprising a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxcodone or a pharmaceutically acceptable salt...
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6518273 |
2-aryl indole derivative as antagonists of tachykinins
The present invention relates to compounds of the formula (I): wherein R 1a , R 1b , R 2 , R 3 , R 4 , R 5 , X and n are defined herein. The compounds are of particular use in the treatment or...
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6518269 |
Cancer treatment
This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing an aldehyde 5-oxo-1,2,4-triazine hydrazide...
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6514934 |
Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with...
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6514988 |
Condensed-ring thiophene derivatives, their production and use
A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or...
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6498172 |
Prostaglandin agonists and their use to treat bone disorders
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6486157 |
Use of insecticides in pest control
The present invention is a method of controlling pests in and on transgenic crops of useful plants, such as, for example, in crops of maize, cereals, soya beans, tomatoes, cotton, potatoes, rice...
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6472392 |
Triazole compounds and the use thereof as dopamine-D3 -ligands
Triazole compounds of the following formula: where Ar 1 , A, B and Ar 2 have the meanings given in the description, possess a high affinity for the dopamine D 3 receptor and can therefore be...
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6465461 |
Triazine compounds for treatment of CNS disorders
A compound of formula (I) and pharmaceutically acceptable prodrugs, salts and solvates thereof.
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6465460 |
Compositions and methods for prevention and treatment of protozoal disease
A composition is provided that has been specially adapted for parenteral administration, e.g., intranasal, intramuscular, subcutaneous, transdernal or intraveneous administration, wherein the...
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6448248 |
Heterocyclic carboxylic acid derivatives, the production and use thereof as endothelin receptor antagonists
The present invention relates to carboxylic acid derivatives of the formula I where the substituents have the meanings explained in the description, and to preparation and use as endothelin...
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6436421 |
Pesticide compositions
The present invention relates to pesticide compositions. In particular, the present invention relates to pesticide compositions comprising a pesticide and a redispersible polymer and to a method...
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6436935 |
Semi-solid aqueous preparations for oral applications of toltrazuril sulphone
The present invention relates to orally administrable pastes of toltrazuril sulfone, comprising active compound in a concentration of 0.1-20% by weight, with a particle size of from 1 to 10·10...
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6426346 |
6-membered aromatics as factor Xa inhibitors
The present application describes 6-membered aromatics of formula I: or pharmaceutically acceptable salt forms thereof, wherein D may be CH 2 NH 2 or C(═NH)NH 2 , which are useful as...
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6423716 |
Nitrogenous heterocyclic compounds
The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR 1 R 2 (wherein R 1 ...
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6403645 |
Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them
Norepinephrine uptake 2 inhibitors (or their precursors) are administered to enhance the effect of norepinephrine reuptake inhibitors and other antidepressants. The uptake 2 inhibitor may be...
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6399620 |
Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I) R 1 —Y—A—B—D—E—F—G (I) in which R 1 , Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and...
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6395732 |
Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in the control of helicobacter bacteria
The present invention relates to compounds of formula (I) wherein R1, R2, and R3 are hydrogen, 1-4C-alkyl, or halogen; R4, R5, R6, and R9 are hydrogen or 1-4C-alkyl; R7 and R8 are hydrogen,...
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6387906 |
2,4,4-trisubstituted-1,3-dioxolane antifungals
The present invention concerns novel compounds of formula a N-oxide form, a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein n is zero, 1, 2 or...
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6384032 |
Inhibitors of IL-12 production
The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof...
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6380192 |
Triazine compounds and method of use therefor
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a substituted...
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6369084 |
Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester...
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6362193 |
Cycloalkenyl substituted compounds
Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
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