|
Match
|
Document |
Document Title |
|
|
7622469 |
2,4-diamino-1,3,5-triazine derivatives
The present invention relates to an antibacterial agent, which comprises, as an active ingredient, a compound represented by the following general formula (1):
or a pharmaceutically acceptable...
|
|
|
7619083 |
Intermediates useful in preparing certain pyrrolotriazine compounds and process for making such intermediates
The invention relates to 2,4-dichloropyrrolo[1,2-f][1,2,4]triazines, which are intermediates useful in preparing at least one 2,4-disubstituted pyrrolotriazine compound, and at least one method for...
|
|
|
7618968 |
Aryl triazines as LPAAT-β inhibitors and uses thereof
The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
|
|
|
7601723 |
Pyridyl substituted xanthines
The present invention provides compounds and pharmaceutical compositions that are substituted pyridyl-linked-xanthines of formula I
which are selective antagonists of A 2B adenosine receptors...
|
|
|
7598246 |
Bisphosphonate conjugates and methods of making and using the same
The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer,...
|
|
|
7589092 |
Prodrugs of heteroaryl compounds
The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
|
|
|
7566710 |
Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof
The invention relates to dual molecules formed from coupling products complying with the formula
wherein A represents a residue of molecule with anti-malarial activity, Y 1 and Y 2 ,...
|
|
|
7563790 |
Pyridazine derivatives
Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid arthritis,...
|
|
|
7544684 |
Hydrazono-malonitriles
Hydrazono-malonitrile derivatives of the formula (I) in which R 1 , R 2 , R 3 , R 3′ and R 4 have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for...
|
|
|
7541357 |
Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
The compounds of the present invention are represented by the chemical structure found in Formula (I):
wherein:
the carbon atom designated * is in the R or S configuration; and X is a fused...
|
|
|
7528132 |
Kinase inhibitors
A compound having the general structure of Formula (I):
or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as...
|
|
|
7521553 |
Crystalline forms of lamotrigine
The present invention relates to novel crystalline forms of lamotrigine, to processes for their preparation and pharmaceutical compositions containing them.
|
|
|
7514428 |
Pesticidal 1-aryl-3-amidoxime-pyrazole derivatives
1-Arylpyrazole-3-substituted-amidoxime derivatives of formula (Ia) or (Ib):
or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof,...
|
|
|
7507734 |
Pyridazinone derivatives
Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R 1 and R 2 are detailed in the description, as well as their physiologically acceptable...
|
|
|
7504501 |
Antiprotozoal imidazopyridine compounds
Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and...
|
|
|
7501415 |
Selective inhibitors of ERK protein kinase and uses thereof
Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a...
|
|
|
7498330 |
4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds
Compound of formula (I):
wherein:
represents 1-oxidopyridyl substituted by the remainder of the molecule in any one of the positions 2, 3 and 4,
m and n, which may be identical or...
|
|
|
7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
|
|
|
7470687 |
Aryl oximes
Aryl oxime derivatives of the formula (I), in which R 1 , R 2 , R 3 , X and B are as defined in Claim 1 , act as phosphodiesterase IV inhibitors and can be employed for the treatment of...
|
|
|
7442699 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure:
wherein R 1 ...
|
|
|
7429590 |
Antiprotozoal imidazopyridine compounds
Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals...
|
|
|
7410968 |
Capped pyrazinoylguanidine sodium channel blockers
The present invention relates to compounds represented by formula (I):
where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
|
|
|
7407962 |
Heteroaryl compounds useful as inhibitors or protein kinases
The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative...
|
|
|
7399762 |
Opioid receptor agonist compounds and their use in treatment of pain
Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.
|
|
|
7381723 |
Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9,-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists
Compounds of the formula
are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and are also...
|
|
|
7371743 |
Carboxylic acid amides, the preparation thereof and their use as medicaments
The present invention relates to new substituted carboxylic acid amides of general formula
wherein A, B and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the...
|
|
|
7358244 |
Azabicycloalkane compounds
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
|
|
|
7354924 |
Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl...
|
|
|
7348335 |
Compositions useful as inhibitors of JAK and other protein kinases
The present invention provides a compound of formula I:
or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the...
|
|
|
7344730 |
Soil granulates with controlled active ingredient release (cr soil granulates)
The present invention relates to soil-applied CR granules obtainable by applying an active-ingredient-comprising coating to a solid carrier in a fluidized bed, to a process for the preparation of...
|
|
|
7344706 |
UV absorber compositions comprising a hydroxyphenyltriazine compound
UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R 1 , R 2 and R 3 are each independently of the others C...
|
|
|
7332494 |
Method for treating allergies using substituted pyrazoles
A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
|
|
|
7326706 |
Pyrazine modulators of cannabinoid receptors
The present application describes compounds according to Formula I, wherein A, G 1 , G 2 and R 1 are described herein. Additionally, the present application describes pharmaceutical compositions...
|
|
|
7312227 |
Compositions useful as inhibitors of JAK and other protein kinases
The present invention provides a compound of formula I:
or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the...
|
|
|
7307079 |
1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors
The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-A 3 receptors, as well as to pharmaceutical compositions containing a pharmacologically active...
|
|
|
7291616 |
Aryl triazines as LPAAT-β inhibitors and uses thereof
The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
|
|
|
7268134 |
Medical devices employing triazine compounds and compositions thereof
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is...
|
|
|
7250416 |
Azacytosine analogs and derivatives
Compounds and compositions of azacytosine analogs and derivatives are provided. In one aspect of the invention, analogs or derivatives of decitabine and azacitidine are provided with modification...
|
|
|
7250412 |
PH sensitive prodrugs of 2,6-Diisopropylphenol
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby...
|
|
|
7244732 |
Prodrugs of heteroaryl compounds
The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
|
|
|
7244417 |
Stabilization of oxidation-sensitive or UV-sensitive active ingredients
The cosmetic or dermatological formulations of the invention include:
(a) at least one oxidation-sensitive or UV-sensitive active ingredient, (b) at least one dialkyl naphthalate which is...
|
|
|
7235560 |
Pyrimidine derivative as selective COX-2 inhibitors
The invention provides the compounds of formula (I)
or a pharmaceutically acceptable salt thereof.
Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the...
|
|
|
7235253 |
Powder containing physiologically active peptide
A method is disclosed for stabilizing a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the...
|
|
|
7226927 |
Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I:
wherein A, Ar 1 , Ar 2 , R 1 and R 3 are defined...
|
|
|
7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
|
|
|
7214365 |
Stablization of oxidation-sensitive or UV-sensitive active ingredients
Cosmetic and dermatological formulations comprising at least one hydrophilic active ingredient and at least one dialkyl naphthalate which is characterized by the structural formula
in which R 1...
|
|
|
7205302 |
Heterocyclic compound derivatives and medicines
The present invention provides a compound which is useful as a PGI 2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition...
|
|
|
7204975 |
Cosmetic and dermatological light-protective formulations with a content of particulate UV-filter substances and alkylnaphthalates
Cosmetic or dermatological formulations comprising at least one particulate UV filter substance and at least one dialkyl naphthalate having the structural formula
wherein R 1 and R 2 are...
|
|
|
7204974 |
Stabilization of oxidation-sensitive or UV-sensitive active ingredients
The invention is a cosmetic or dermatological formulation, comprising:
(a) at least one oxidation- and/or UV-sensitive active ingredient; (b) at least one dialkyl naphthalate which is...
|
|
|
7204973 |
Cosmetic and dermatological light protection formulations with a content of hydroxybenzophenones and alkylnaphthalates
The invention relates to light-protective cosmetic or dermatological preparations that contain (a) at least one hydroxy-benzophenone, and (b) at last one dialkyl naphthalate of the structural...
|