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7608594 |
Novobiocin analogues as anticancer agents
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present...
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7553819 |
Multivalent inhibitors of serum amyloid P component
Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such,...
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7524510 |
Alkyl-glycoside enhanced vaccination
Described herein are methods for the noninvasive immunization of a subject that involve alkyl glycosides. Also described herein are compositions, kits, and devices for the noninvasive immunization...
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7514411 |
Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , W, Y, and Z are defined herein; or a...
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7501399 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7442687 |
2-polycyclic propynyl adenosine analogs having A2A agonist activity
The invention provides compounds having the following general formula (I):
wherein X, R 1 , R 2 , R 7 and Z are as described herein.
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7439232 |
Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
There is provided a heteroaryl 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a...
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7390785 |
τ-conotoxin peptides
The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7223737 |
Method of treating dry eye disorders using glycosides
The topical use of glycosides for the treatment of dry eye disorders is disclosed.
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7199106 |
Lincomycin derivatives possessing antimicrobial activity
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria,...
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7183261 |
Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs
Galactosylceramide analogues represented by the following formula (1) or (2).
(wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having...
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7179794 |
Multivalent macrolide antibiotics
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7153826 |
Treatment of rosacea
Cyclic peptide antibiotics including the loloatins are effective in the treatment of rosacea, particularly when administered in conjunction with an antibiotic such as metronidazole that is...
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7129219 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7060732 |
Antibiotic/benzoyl peroxide dispenser
Two separate compositions, one containing an effective anti-acne treating amount of a first active ingredient and one containing a second active ingredient that is incompatible with the first...
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7056702 |
Detecting lipocalin
The invention provides antibodies reactive with distinct lipocalin epitopes that are useful for detecting inflammation and bacterial infections in mammals.
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7029671 |
Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof
The invention relates to a method for activating human-derived antigen-presenting cells by in vitro cultivation with at least one of the glycoside compounds represented by formula (A) or salts...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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6979675 |
Treatment of cancer with 2-deoxyglucose
The compound 2-deoxyglucose can be used to treat cancer and to improve patient outcome when administered at a therapeutically effective dose, and, optionally, co-administered with other anti-cancer...
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6911434 |
Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ cyclic AGPs for...
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6908903 |
Cluster clearing agents
Cluster clearing agents (CCAs) and the use thereof are discussed. CCAs are composed of a hepatic clearance directing moiety which directs the biodistribution of a CCA-containing construct to...
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6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
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6800613 |
Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds
Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and...
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6794370 |
Method for treating cancer using camptothecin derivatives and 5-fluorouracil
A combination therapy for treating cancer including administering at least one camptothecin derivative in conjunction with another anticancer agent. The combination therapy is preferably used as a...
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6793921 |
Specific antibodies for use in preparation of pharmaceutical compositions useful in the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers
The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained...
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6787525 |
Glyceryl nucleotides, method for the production thereof and their use
The invention relates to glyceryl nucleotides of the formula Ia in which a) one of the radicals A 1 , A 2 and A 3 is a hydrogen atom or a radical selected from hydroxyl, mercapto, alkyl,...
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6777004 |
Composition containing novel compound corniculatonin having antifungi properties and a process for preparing the same
The invention relates to a novel compound oleanane triterpenoid oligoglycoside of formula 1 of the accompanying drawing (trivially called corniculatonin), the invention also relates to a process...
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6773707 |
Heat shock protein-based vaccines and immunotherapies
The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to...
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6713074 |
Cosmetic composition and method
The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation...
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6677317 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
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6673357 |
Alkaloid glycoside for use as a medicament
The invention concerns an alkaloid glycoside for use in medicine. In a preferred aspect, the alkaloid glycoside is used for the stimulation of a class I-restricted immune response and/or a class...
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6670330 |
Cancer chemotherapy with 2-deoxy-D-glucose
A class of glycolytic inhibitors is useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are...
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6663886 |
Inhibition of cell-cell binding by lipid assemblies
This invention relates generally to the field of therapeutic compounds designed to interfere between the binding of ligands and their receptors on cell surface. More specifically, it provides...
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6642205 |
Methods and compositions for reducing side effects in chemotherapeutic treatments
A pharmaceutical compound and a process for making the compound is provided where the compound includes a therapeutic agent, a spacer and a galactose, the spacer being covalently linked to the...
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6635622 |
Glycolipid derivative
The present invention is a compound of general formula (I) or a pharmaceutically acceptable salt of, wherein W represents carbon chain from 9 to 17 which containing double bond or hydroxy group...
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6610316 |
Disinfection by particle-bound and insolubilized detergents
A detergent such as nonionic, cationic or anionic detergents and preferably a “sugar detergent” such as octyl-glucopyranoside is rendered insoluble by being bound to an inert substrate. This...
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6518259 |
Compositions for treating autoimmune disease
Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of...
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6492336 |
Peritoneal dialysis fluid
Peritoneal dialysis fluids and the use thereof for performing peritoneal dialysis are disclosed. The peritoneal dialysis fluid comprises a physiologically acceptable aqueous solution containing...
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6475520 |
Pharmaceutical composition with low toxicity for anti-inflammation and anti-exudation
The present invention relates to a pharmaceutical composition with low toxicity for anti-inflammatory and anti-exudative which contains as active ingredients escin with general formula I and escin...
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6451766 |
Neuraminic acid derivatives, their preparation and their medical use
Compounds of formula (I) or their salts or esters: [wherein R 1 is alkyl or haloalkyl; R 2 and R 3 each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of...
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6448233 |
Topical application of a combination of benzoyl peroxide and a second active ingredient
Disclosed herein is a dispensing system for benzoyl chloride and an antimicrobial agent which antimicrobial agent is a macrolide or an aminoglycoside antibiotic. The dispensing system comprises a...
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6358493 |
Methods of performing cosmetic treatments with gasified solid particles and instant gel preparations containing the gasified solid particles
Gasified particles for cosmetic treatments, particularly hair treatments, are described. The gasified particles contain at least one gas enclosed in a solid enveloping material. The enveloping...
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6322814 |
Manufacture of and uses for low molecular weight agars and agaroids
A process is claimed whereby an aqueous solution of agar, in which most (ideally all) 4-linked residues consist of 3,6-anhydro-L-galactose, is subjected to partial acid hydolysis and upon...
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6303644 |
Proton pump inhibitor in therapeutic combination with antibacterial substances
The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially...
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6291433 |
Derivatives of α-D-Thioxyloside and their use against atheroma
The present invention concerns, as new industrial products, the α-D-xylose compounds of formula I: ##STR1## wherein X and Y represent, independently of one another, an oxygen atom or a sulphur...
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