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5660855 |
Lipid constructs for targeting to vascular smooth muscle tissue
A lipid construct comprising an aminomannose derivatized cholesterol suitable for targeting smooth muscle cells and tissue. Preferred formulations contain...
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5661130 |
Absorption enhancers for drug administration
The present invention relates to a method of increasing the absorption of a compound via the ocular, nasal, nasolacrimal or inhalation route into the circulatory system of a patient. In particular,...
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5650394 |
Use of urinastatin-like compounds to prevent premature delivery
The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by...
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5639734 |
Disaccharide inflammation inhibitors and uses thereof
The present invention provides a composition of matter comprising a biosynthetic anti-inflammatory oligosaccharide, comprising the structure of: sugar - sugar - X - R; wherein said sugar is...
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5629023 |
Medical food composition for metabolic detoxification
A medical food having the below listed components is administered for several days as the sole source or as a substantial source of the daily caloric intake of a patient suffering from metabolic...
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5618820 |
1,3-oxathiolane nucleoside analogues and methods for using same
The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to...
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5583160 |
Methylsphingosine used to treat apoptosis
N-methylated sphingosine used to induce apoptosis.
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5472946 |
Transdermal penetration enhancers
This invention relates to compounds and a method for their use in carrying physiologically active agents through body membranes such as skin and for retaining these agents in body tissues. More...
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5369095 |
Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers
The use of substituted glycosides to enhance the penetration of drugs across mucus covered epithelial tissues of humans and animals is disclosed, including enhanced penetrations of topically...
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5367062 |
Disubstituted and deoxydisubstituted derivatives of α-d-lyxofuranosides having anti-inflammatory and anti-proliferative activity
Derivatives of disubstituted and deoxydisubstituted α-D-lyxofuranosides and intermediates for preparing these derivatives are described. These compounds exhibit significant antiinflammatory and...
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5342612 |
Compositions for the treatment of mammalian diseases
A therapeutic composition which contains a potentiating or safening amount of an aqueous surfactant in combination with a bactericidal agent and/or a biological response modifier is described...
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5258181 |
Compositions containing psyllium
The present invention relates to compositions comprising psyllium fiber and peanut paste, and the use of these compositions as laxatives and/or for cholesterol reduction benefits. The compositions...
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5256647 |
Compositions comprising 1-substituted azacycloalkanes
This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or...
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5206020 |
Synthetic pseudoceramide and cosmetic compositions thereof
Novel pseudoceramides are compounds with a general structure (2): ##STR1## In this formula a is 0 or 1, b is 0 or 1 but if a is 0, b is also 0 and R has 1 to 8 carbon atoms. The substituents R and...
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5141925 |
Vivo methods for treating coccidiosis
The present invention provides a method for the prophylactic and/or therapeutic treatment of living animals susceptible to infection by at least one parasite able to cause Coccidiosis. The...
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5135919 |
Method and a pharmaceutical composition for the inhibition of angiogenesis
Fumagillin and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization. The invention also...
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5100913 |
Novel sulfonylphenyl-β-D-thioxylosides, their method of preparation and their use in therapeutics
The present invention relates, by way of novel industrial products, to the sulfonylphenyl-β-D-thioxyloside compounds of the formula ##STR1## in which: X is a sulfur atom or an oxygen atom; R is...
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5082656 |
Topical antibacterial compositions containing penetration enchancers
An antibacterial composition for topical administration, comprising from about 0.5 to about 10 percent of an antibacterial compound; from about one to about 30 percent of a non water soluble...
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5073544 |
Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes
This invention provides compositions for enhancing penetration of physiologically active agents through the skin or mucosal membranes and for retaining these agents in body tissues, said...
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5061729 |
Pharmaceutical composition and process for preparing the same
The invention relates to pharmaceutical compositions as well as the preparation thereof which are useful for improving the status of patients suffering from external otitis or otitis (otitis...
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5053498 |
Therapeutic and prophylactic agents for peptic ulcer
A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R 1 represents hydrogen or O; R 2 ...
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5051407 |
Methods for treating viruses in patients by administering 2-hydroxymethylene-3,4,5-trihydroxypiperidines
A method for treating a viral infection in a human or animal patient comprising administering to such patient an antivirally effective amount of a substituted hydroxypiperidine, namely a...
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5045533 |
Retinoic esters of antibiotics and pharmaceutical and cosmetic compositions containing them
All trans or 13-cis retinoic acid esters of macrolide and lincosamide antibiotics. These esters are useful in the therapeutic and cosmetic treatment of dermatosis and principally in the treatment...
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5019568 |
Steroidal glycolipids as host resistance stimulators against viral infection
Disclosed are pharmaceutical compositions for enhancing human host resistance against opportunistic infection in an individual immunocompromised by an AIDS-related virus, consisting essentially of...
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5004734 |
Diaromatic esters of macrolidic and lincosamidic antibiotics and pharmaceutical and cosmetic compositions containing them
Diaromatic esters of macrolidic and lincosamidic antibiotics are employed in the treatment of acne.
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5004729 |
Aromatic esters of macrolidic and lincosamidic antibiotics and pharmaceutical and cosmetic compositions containing them
Aromatic esters of macrolidic and lincosamidic antibiotics are employed in the treatment of acne.
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5004733 |
Esters of the etretinic type or related to macrolidic and lincosamidic antibiotics and pharmaceutical and cosmetic compositions containing said esters
Esters of the etretinic type or related to macrolides and lincosamides are employed in the treatment of acne and psoriasis.
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5004730 |
Polycyclic aromatic esters of macrolidic and lincosamidic antibiotics and pharmaceutical and cosmetic compositions containing them
Polycyclic aromatic esters of macrolidic and lincosamidic antibiotics are employed in the treatment of acne.
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5004731 |
Unsaturated cycloaliphatic esters of macrolidic and lincosamidic antibiotics and pharmaceutical and cosmetic compositions containing them
Unsaturated cycloaliphatic esters of macrolidic and lincosamidic antibiotics are employed in the treatment of acne.
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5004732 |
Polyaromatic esters of macrolidic and lincosamidic antibiotics and pharmaceutical and cosmetic compositions containing them
Polyaromatic esters of macrolidic and lincosamidic antibiotics are employed in the treatment of acne.
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4960758 |
Novel β-D-phenylthioxylosides, their method of preparation and their use as pharmaceuticals
The present invention relates to β-D-phenylthioxyloside compounds selected from the group consisting of: (i) the β-D-phenylthioxylosides of the formula: ##STR1## in which: R 1 and R 2 , which...
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4957904 |
Perfluoroalkylthioglycosides
Novel nonionic perfluoroalkylthioglycosides of the formula, R f -E-S-saccharide are described, wherein R f is a straight or branched chain perfluoroalkyl of 1 to 18 carbon atoms or said...
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4939123 |
Glycopeptide and oligosaccharide antibacterial compositions
Adherence of pathogenic bacteria having type I fimbriae to animal cells is inhibited by compositions having active constituents which are new glycopeptide and/or oligosaccharide compounds. The...
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4939176 |
Viral inactivation process
Lipid-enveloped viruses present in purified biologically active protein products obtained from blood or cell culture systems can be inactivated by contacting the products with caprylic acid at a...
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4920101 |
Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
This invention provides compositions comprising a physiologically-active agent and a compound represented by the general formula ##STR1## wherein X may represent sulfur, oxygen or 2 hydrogen...
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4906617 |
Pharmaceutical compositions containing saturated aromatic peroxides
A pharmaceutical or cosmetic composition contains as an active principle a peroxide having an aromatic radical and a saturated group and having the formula ##STR1## wherein R 1 represents linear...
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4902676 |
Compositions comprising N,N-dialkylalkanamides
This invention provides compositions comprising a physiologically-active agent and a compound represented by the general formula ##STR1## wherein R 1 and R 2 are independently selected from the...
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4902675 |
"2-pyridyl and 4-pyridyl phosphine gold (I) anti tumor complexes"
2-pyridyl and 4-pyridyl phosphine gold compounds of the formula: ##STR1## and 2-pyridyl phosphine gold compounds of the formula: ##STR2## and pharmaceutical compositions containing an effective,...
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4886781 |
Substituted 2,3-diphenyl-1,2-dihydroquinoxalines and antibiotics for growths promoting
Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are...
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4877808 |
Novel β-D-phenylthioxylosides, their method of preparation and their use as therapeutics
The present invention relates, by way of novel industrial products, to osides selected from the group consisting of: (i) the β-D-phenylthioxylosides of the formula: ##STR1## in which: R...
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4877807 |
5-phenyl-1,2,3a,4,5,9b-hexahydro-3H-benz(e)indotes preparation and use thereof as drugs
A 5-phenyl-1,3,3a,4,5,9b-hexahydro-3H-benz(e)indole compound of the formula I: ##STR1## wherein R 1 is hydrogen or C 1 -6 alkyl, R 2 is hydrogen or C 1 -3 alkyl in the 3a- or 4-position, R 3 and...
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4874423 |
Solid, herbicidal complexes
Low viscosity heteropolysaccharides, e.g., xanthan gum, S-194, and guar gum, are disclosed. These gums are especially useful in preparing herbicidal compositions.
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4835140 |
Method for treating pneumocystis carinii pneumonia patients with clindamycin and primaquine
The combination of clindamycin and primaquine or pharmaceutical salts thereof is effective in treating patients with Pneumocystis carinii pneumonia.
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4803228 |
Unsaturated aromatic peroxides and their use in pharmaceutical and cosmetic compositions
A peroxide having an aromatic radical and an unsaturated group has the formula ##STR1## wherein R represents linear or branched, mono- or polyunsaturated alkenyl having 5 to 21 carbon atoms or...
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4755535 |
Compositions comprising 1-substituted azacycloalkenes
This invention provides compositions comprising a physiologically-active agent and an azacycloalkene having at least one double bond in the ring and of the general formula ##STR1## wherein X and Y,...
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4743588 |
Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents
Compositions and methods useful for enhancing the transdermal and transmembrane drug delivery of topical and systemic agents. The compositions and methods comprise the active agent together with an...
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4678660 |
Thermoplastic polyurethane anticoagulant alloy coating
An antithrombogenic thermoplastic polyurethane product and process for preparing the same which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a...
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4645756 |
[α,ω-bis(diphenylphosphino)hydrocarbon]bis[(thiosugar)gold] and bis[(selenosugar)gold] derivatives, pharmaceutical compositions and method of use
This invention relates to [α,ω-bis(diphenylphosphino)hydrocarbon]bis[(thiosugar)gold
] and bis[(selenosugar)gold] derivatives, pharmaceutical compositions comprising an effective tumor cell...
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4639436 |
Antidiabetic 3,4,5-trihydroxypiperidines
The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said...
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4607101 |
Method of treating acne vulgaris with a composition containing carbamide peroxide
An improved method of treating acne vulgaris comprising administering a therapeutically effective amount of carbamide peroxide alone or in combination with one or more of a topical antibiotic,...
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