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7273867 |
Phenyl derivatives
Novel compounds of the formula I in which W, X, Y, T, R 1 and R 2 are as defined in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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7232821 |
(2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof:
wherein A, R 1 , R 2 , R x , R 8 , R 9 and n are as defined in the specification, a process for the preparation of...
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7223755 |
Hydroxymorpholinone derivative and medicinal use thereof
A compound represented by the following formula (I)
wherein R 1 and R 2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6887872 |
Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition...
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6777411 |
Fungicide mixtures based on pyride amides and morpholine derivatives or piperidine derivatives
Fungicidal mixtures comprising as active components a) an amide compound of the formula I A—CO—NR 1 R 2 I in which A is an aryl group or an aromatic or non-aromatic, 5- or 6-membered...
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6743788 |
Carbamate and oxamide compounds
Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or...
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6734202 |
Fungicidal mixtures
The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at...
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6734177 |
Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said...
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6727250 |
Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation
Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1)...
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6673794 |
Substituted aminomethyl-phenyl-cyclohexane derivatives
A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are...
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6649616 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
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6638930 |
Morpholine and thiomorpholine tachykinin receptor antagonists
Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium...
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6586427 |
Treatments for nervous disorders
This patent application describes the treatment of Addictive disorders, Psychoactive Substance Use disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco addiction and...
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6541500 |
Fungicide mixture
Fungicidal mixtures, comprising as active components a) a compound of the formula I its N-oxide or one of its salts where: R 1 , R 2 , R 3 , R 4 independently of one another are: hydrogen,...
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6455520 |
Benzamide derivatives and their use as cytokine inhibitors
The invention concerns amide derivatives of formula (I) wherein R 3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R 1 and R 2 is a group such as hydroxy, halogeno,...
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6413987 |
Dermal anesthetic agents
The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as...
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6369090 |
Fungicidal mixture
Fungicidal mixtures comprise a.1) a carbamate of the formula I.a, in which X is CH or N, n is 0, 1 or 2 and R is halogen, alkyl or haloalkyl, or a.2) the oxime ether carboxamide of the formula...
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6294531 |
Calcilytic compounds
Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
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6262104 |
Diarylalkenylamine derivatives
Compounds, or solvates or salts thereof, of formula (I): ##STR1## selective delta opioid agonists and antagonists and may be of therapeutic utility as analgesics, immunosuppressants to prevent...
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6235791 |
Use of amines to produce drugs for preventing tumor cell proliferation
The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of...
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6184222 |
Treatment of conduct disorder
Norepinephrine reuptake inhibitors are used to treat conduct disorder.
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6180624 |
Tachykinin antagonist and an opioid analgesic effective at treating pain or nociception
This invention relates to methods and compositions for treating pain and nociception in a patient by administering a combination of a morpholine or thiomorpholine tachykinin antagonist and an...
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6166013 |
Glucocortiocoid-selective agents
Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods...
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6136803 |
Antidepressants
The present invention provides novel compounds such as certain aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake. The...
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6133267 |
Use of 2-(2-morpholinophenyl) guanidine derivatives for the treatment of diabetes complications
A compound of formula I ##STR1## or a pharmaceutically acceptable salt thereof in which R 1 and R 2 are independently H or methyl (for example 1,1-dimethyl-2-(2-morpholinophenyl)guanidine...
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6046193 |
Treatment of attention-deficit/hyperactivity disorder
Reboxetine is used to treat attention-deficit/hyperactivity disorder.
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6028070 |
Treatment of oppositional defiant disorder
Norepinephrine reuptake inhibitors are used to treat oppositional defiant disorder.
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5958982 |
Method for treating patients with sarcoidosis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols
Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of sarcoidosis.
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5932575 |
Cardiac diseases improving agents
This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly,...
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5914340 |
Leukotriene antagonists useful for treating dermatoses
This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
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5905072 |
Adjuvants for systemic fungicides, fungicidal compositions which contain them and their use
Adjuvants for systemic fungicides in the form of a stable microemulsion comprise water, a mixture of methyl esters of fatty acids obtained by the transesterification of vegetable oils, an anionic...
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5902827 |
Method for treating patients with psoriasis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols
Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of psoriasis.
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5885990 |
Substituted amidinonaphthyl ester derivative
Substituted amidinonaphthyl ester compounds effective for treatment of thrombosis are represented by the following formula (I) and pharmaceutically acceptable acid addition salts thereof: ##STR1##...
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5874435 |
4-heteroaryl-1-piperazinealkanols and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5869484 |
Phenylcarbamate derivatives suitable to the use as anticholinesterase substances
Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R 1 -R 7 and X substituentes together with n will...
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5856324 |
Use of dioxomorpholines for combat endoparasites, dioxomorpholines and process for their production
The present invention relates to the use of dioxomorpholines of the formula (I) ##STR1## in which the radicals R 1 to R 5 have the meanings given in the description, their use for combating...
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5817684 |
Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke
This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having...
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5792762 |
Dihydrobenzofluorene compounds, intermediates, compositions and methods
The invention provides dihydronaphthofluorene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological...
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5767151 |
3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds
The present invention relates to novel 3,3-(disubstituted)-cyclohexan-1-ylidene acetate dimers of Formula (I): ##STR1## and related compounds, pharmaceutical compositions containing these...
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5646158 |
1,3,3-(trisubstituted)cyclohex-1-ene monomers and related compounds
This invention relates to certain 1,3,3-(trisubstituted)cyclohex-1-ene monomers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the...
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5556864 |
α-ω-diarylalkane compounds serotonin-2 receptor agonists
Compounds of formula (I): ##STR1## [wherein: R 1 is aryl; R 2 is hydrogen, alkyl, alkoxy, halogen or cyano; R 3 is a group of formula --B--NR 4 R 5 , where R 4 and R 5 are independently...
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5519018 |
Substituted phenols and their use for the treatment of disorders caused by cell proliferation
Substituted phenols of the formula I ##STR1## processes for their preparation and compositions containing substituted phenols of the formulae I and II ##STR2## for the treatment of disorders caused...
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5491140 |
Naphthyl tachykinin receptor antagonists to treat physiological conditions
This invention provides methods of treating a physiological disorder associated with an excess of tachykinins in a mammal which comprises administering to a mammal in need of said treatment a...
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5476850 |
Amino-substituted benzenesulfonylureas and -thioureas and their use as pharmaceuticals
There are described amino-substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## The compounds I are used for the treatment of cardiac arrhythmias and for the prevention of...
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5472963 |
Fungicidal mixtures employing an oxime ether carboxamide and a morpholine derivative
A fungicidal mixture containing a) the oxime ether carboxamide of the formula I ##STR1## and b) a morpholine or piperidine derivative II selected from the group of compounds IIa, IIb and IIc...
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