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8163727 |
Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders,...
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8093266 |
Rho kinase inhibitors
Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases,...
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8088772 |
Sulfonamides and their use as a medicament
The present invention relates to the use of a sulfonamide compound of formula (I): wherein R1 is selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxy,...
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8080541 |
Carbocyclic GlyT-1 receptor antagonists
The present invention relates to the use of a compound of formula I wherein R1, R2, R3, R4, X and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic...
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7943613 |
Compounds, their preparation and use
Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these...
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7928103 |
Compounds which modulate the CB2 receptor
Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those...
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7875611 |
Ion channel modulating compounds and uses thereof
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and...
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7868004 |
Menthane carboxamide derivatives having cooling properties
A compound of the formula I in which X and Y are selected as follows: (i) X is H and Y is selected from the group consisting of (ii) X and Y together form a bivalent radical selected from the group...
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7737135 |
Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders,...
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7595315 |
Morpholine derivatives as norepinephrine reuptake inhibitors
Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
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7563789 |
1-Adamantyl chalcones for the treatment of proliferative disorders
The present invention relates to the compounds of the general formula (I), a composition for and a method of treating breast cancer or other proliferative disorders in a subject using a compound of...
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7273867 |
Phenyl derivatives
Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of...
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7232821 |
(2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a process for the preparation of such...
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7223755 |
Hydroxymorpholinone derivative and medicinal use thereof
A compound represented by the following formula (I) wherein R1 and R2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof is...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G are each as defined in...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6777411 |
Fungicide mixtures based on pyride amides and morpholine derivatives or piperidine derivatives
Fungicidal mixtures comprising as active components a) an amide compound of the formula IA—CO—NR1R2 I in whichA is an aryl group or an aromatic or non-aromatic, 5- or 6-membered heterocycle whi...
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6743788 |
Carbamate and oxamide compounds
Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or...
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6734177 |
Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said...
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6734202 |
Fungicidal mixtures
The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least...
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6727250 |
Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation
Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are:(1)...
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6673794 |
Substituted aminomethyl-phenyl-cyclohexane derivatives
A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are...
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6638930 |
Morpholine and thiomorpholine tachykinin receptor antagonists
Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium...
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6586427 |
Treatments for nervous disorders
This patent application describes the treatment of Addictive disorders, Psychoactive Substance Use disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco addiction and...
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6541500 |
Fungicide mixture
Fungicidal mixtures, comprising as active components a) a compound of the formula I its N-oxide or one of its salts where:R1, R2, R3, R4 independently of one another are: hydrogen, hydroxyl, nitro,...
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6455520 |
Benzamide derivatives and their use as cytokine inhibitors
The invention concerns amide derivatives of formula (I) wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno,...
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6413987 |
Dermal anesthetic agents
The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as...
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6369090 |
Fungicidal mixture
Fungicidal mixtures comprise a.1) a carbamate of the formula I.a, in which X is CH or N, n is 0, 1 or 2 and R is halogen, alkyl or haloalkyl, ora.2) the oxime ether carboxamide of the formula I.b...
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6294531 |
Calcilytic compounds
Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
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6262104 |
Diarylalkenylamine derivatives
Compounds, or solvates or salts thereof, of formula (I): ##STR1##selective delta opioid agonists and antagonists and may be of therapeutic utility as analgesics, immunosuppressants to prevent...
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6235791 |
Use of amines to produce drugs for preventing tumor cell proliferation
The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of...
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6184222 |
Treatment of conduct disorder
Norepinephrine reuptake inhibitors are used to treat conduct disorder.
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6180624 |
Tachykinin antagonist and an opioid analgesic effective at treating pain or nociception
This invention relates to methods and compositions for treating pain and nociception in a patient by administering a combination of a morpholine or thiomorpholine tachykinin antagonist and an...
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6166013 |
Glucocortiocoid-selective agents
Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods...
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6136803 |
Antidepressants
The present invention provides novel compounds such as certain aryloxy indanamines which are useful as anti-depressants and as inhibitors of synaptic norepinephrine and serotonin uptake. The...
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6133267 |
Use of 2-(2-morpholinophenyl) guanidine derivatives for the treatment of diabetes complications
A compound of formula I ##STR1## or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example 1,1-dimethyl-2-(2-morpholinophenyl)guanidine fumarate)...
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6046193 |
Treatment of attention-deficit/hyperactivity disorder
Reboxetine is used to treat attention-deficit/hyperactivity disorder.
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6028070 |
Treatment of oppositional defiant disorder
Norepinephrine reuptake inhibitors are used to treat oppositional defiant disorder.
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5958982 |
Method for treating patients with sarcoidosis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols
Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of sarcoidosis.
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5932575 |
Cardiac diseases improving agents
This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly,...
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5914340 |
Leukotriene antagonists useful for treating dermatoses
This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
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5905072 |
Adjuvants for systemic fungicides, fungicidal compositions which contain them and their use
Adjuvants for systemic fungicides in the form of a stable microemulsion comprise water, a mixture of methyl esters of fatty acids obtained by the transesterification of vegetable oils, an anionic...
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5902827 |
Method for treating patients with psoriasis by administering substituted sulfonyl indenyl acetic acids, esters and alcohols
Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of psoriasis.
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5885990 |
Substituted amidinonaphthyl ester derivative
Substituted amidinonaphthyl ester compounds effective for treatment of thrombosis are represented by the following formula (I) and pharmaceutically acceptable acid addition salts thereof: ##STR1##...
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5874435 |
4-heteroaryl-1-piperazinealkanols and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5869484 |
Phenylcarbamate derivatives suitable to the use as anticholinesterase substances
Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R1 -R7 and X substituentes together with n will be...
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5856324 |
Use of dioxomorpholines for combat endoparasites, dioxomorpholines and process for their production
The present invention relates to the use of dioxomorpholines of the formula (I) ##STR1## in which the radicals R1 to R5 have the meanings given in the description, their use for combating...
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