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7384941 |
2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
Compounds of formula (I):
wherein A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C 1 -C 4 alkyl, a C 3 -C 6 cycloalkyl...
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7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
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7338953 |
Method of treating chronic fatigue syndrome
Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a...
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7317011 |
Method of treating peripheral neuropathy
Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine,...
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7314875 |
Tricyclic aromatic and bis-phenyl sulfinyl derivatives
The present invention provides compounds of the structure:
wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases...
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7294623 |
Benzyl morpholine derivatives
A compound of formula (I) (I) wherein R is H; Ar is an aromatic group selected from phenyl; X is a phenyl group; R′ is H or C1-C4 alkyl; each R1 is independently H or C1-C4 alkyl; and...
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7141560 |
Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics
The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I
The invention also relates to pharmaceutical compositions comprising said derivatives,...
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6987107 |
Method of treating incontinence
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of...
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6964963 |
Preparation of 4-amino-1-naphthol ethers
The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted...
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6964962 |
Combinations of reboxetine and neuroleptic agents
A composition comprising:
(a) a pharmaceutically effective amount of reboxetine; and selected from the group consisting of clozapine, olanzapine, risperidone and mixtures thereof (b) a...
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6900203 |
Optically active fluorinated vasoconstrictors, methods for making them, and anesthetic formulations comprising them
(R)-6F-phenylephrine, essentially free of (S)-6F-phenylephrine, and an anesthetic formulation comprising (R)-6F-epinephrin or (R)-6F-phenylephrine and having improved stability compared to...
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6878706 |
Cyanamides useful as reversible inhibitors of cysteine proteases
Compounds according to the following formula (I):
wherein the variables Q and R 1 to R 6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F,...
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6787543 |
Benzhydryl derivatives
A compound of the formula (I): in which Z, R 1 , R 2 , R 8 , R 10 , R 11 , R 12 , R 13 and R 14 are each as defined in the description, or a salt thereof. The object compound of the present...
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6703389 |
Method of treating chronic pain
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of...
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6642235 |
Method of treating migraine headaches with a highly selective noreoinephrine reuptake inhibitor
Methods for treating humans suffering from, migraine headaches by inhibiting reuptake of norepinephrine are disclosed. The methods comprise a compound having a pharmacological selectivity of...
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6610690 |
Method of treating or preventing fibromyalgia and other somatoform disorders with a highly selective norepinephrine reuptake inhibitor
This application relates to methods for treating humans suffering from, fibromyalgia or other somatoform disorders where inhibiting reuptake of norepinephrine is a benefit. The methods comprise a...
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6586431 |
3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives
The present invention relates to compounds of the formula I, wherein Z 1 , Z 2 , X, Q, R 1 , R 2 and R 3 are defined as in the specification, pharmaceutical compositions containing such...
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6586427 |
Treatments for nervous disorders
This patent application describes the treatment of Addictive disorders, Psychoactive Substance Use disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco addiction and...
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6541523 |
Methods for treating or preventing fibromyalgia using very low doses of cyclobenzaprine
The present invention relates to methods and compositions comprising a very low dose of cyclobenzaprine or metabolite thereof for preventing and treating sleep disturbances and illnesses manifested...
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6541471 |
Benzenesulphonamide compounds
A compound of formula (I): wherein: G represents a group such as: wherein R 1 and R 2 independently represent a hydrogen atom or an alkyl, cycloalkyl, aryl, arylalkyl, cycloalkyl,...
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6500827 |
Drug combinations
This patent application describes a new combination treatment of selective, noradrenaline-reuptake inhibitors (NARI) and specifically, reboxetine, and pindolol to provide rapid relief to patients...
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6500826 |
Use of panaverium bromide for preventing cell proliferation and diseases caused thereby in the liver and digestive tract
The use of panaverium bromide for treating or preventing diseases of the liver and digestive tract caused by excessive cell proliferation therein, is disclosed.
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6479491 |
Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R 1 , R 2 , R 3 , R 4...
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6465458 |
Method of treating or preventing chronic pain with a highly selective norepinephrine reuptake inhibitor
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of...
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6465457 |
Carbonate, carbamate, thiocarbonate dithiocarbonate and thiocarbomate derivatives useful as fungicides
Fungicidal compounds of formula (I): wherein W is CH 3 O.CH═CCO 2 CH 3 , CH 3 ON═CCONR 3 R 4 or CH 3 ON═CCO 2 CH 3 and stereoisomers thereof; n is 0 or 1; X is oxygen or sulphur; Z is NR...
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6458781 |
Substituted diarylalkyl amides as calcium channel antagonists
The present invention provides compounds that block calcium channels and have the Formula I: The present invention also provides pharmaceutical compositions containing the compounds of Formula I...
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6451817 |
Alpha-substituted-1-benzyl-napthyls
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether, amino, hydrazino, cyano or halo...
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6441038 |
Treatment of fatigue, head injury and stroke
A method of treatment of disorders of neurological origin and drug formulations for use in the method are disclosed. These conditions comprise fatigue and associated syndromes of pain, weakness and...
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6413961 |
Irrigation solution and method for inhibition of pain and inflammation
A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic...
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6391892 |
Naphthyl pharmaceutical compounds
The present invention provides a compound of formula I wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH(C 1 -C 6 ...
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6391876 |
Reboxetine for treatment obsessive compulsive disorders and panic disorder
This invention relates to the use of reboxetine in the treatment of Obsessive Compulsive Disorders and Panic Disorders.
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6384053 |
α-substituted-1-benzyl-napthyls
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether amino, cyano or halo that are...
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6365131 |
Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic
Pharmaceutical dental gel preparation comprising of metronidazole benzoate, chlorhexidine gluconate, and local anesthetic as the active ingredient; glycol as the solvent medium; a carboxyvinyl...
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6284799 |
Cancer treatment
The present invention is concerned with the identification of compounds which increase the therapeutic index of chemotherapy drugs and which stimulate the growth of cancers, their use in the...
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6184222 |
Treatment of conduct disorder
Norepinephrine reuptake inhibitors are used to treat conduct disorder.
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6177427 |
Treatment of glaucoma and ocular hypertension
Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.
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6177067 |
Hair revitalizing tonic composition containing a 2,2-dimethylpropanediol compound and use thereof
Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula: ##STR1## wherein R 1 and R 2 are each independently a C 1 -30 hydrocarbon group...
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6051573 |
Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists
Compositions of non-steroidal glucocorticoid antagonists for treating GLC1A glaucoma and methods for their use are disclosed.
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6046193 |
Treatment of attention-deficit/hyperactivity disorder
Reboxetine is used to treat attention-deficit/hyperactivity disorder.
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6028070 |
Treatment of oppositional defiant disorder
Norepinephrine reuptake inhibitors are used to treat oppositional defiant disorder.
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6017918 |
Phenyl glycine compounds and methods of treating atherosclerosis and restenosis
The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the...
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6013649 |
Thiol sulfone metalloprotease inhibitors
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors,...
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5962507 |
O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them
Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p...
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5958917 |
Benzofluorene compounds, intermediates, compositions, and methods
The present invention provides compounds of formula I ##STR1## wherein R 1 is --H, --OH, --O(C 1 -C 4 alkyl), --OCO(C 1 -C 6 alkyl), --OCOO(C 1 -C 6 alkyl), --OCOAr, --OCOOAr, or --OSO 2 (C...
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5914340 |
Leukotriene antagonists useful for treating dermatoses
This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
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5872117 |
1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
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5869484 |
Phenylcarbamate derivatives suitable to the use as anticholinesterase substances
Phenylcarbamate derivatives suitable to the use as anticholinesterase substances having the general formula (I) ##STR1## wherein the meaning of R 1 -R 7 and X substituentes together with n will...
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5859065 |
Treatment method for cancer
The in vivo chemotherapeutic treatment of cancer cells in a living animal is improved by first administering to the animal, a compound which inhibits normal cell proliferation while promoting...
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5821253 |
Tetrahydrobenzo a!fluorene compounds and methods of use
The invention provides tetrahydrobenzo a!fluorene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological...
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5817684 |
Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke
This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having...
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