Matches 51 - 100 out of 178 < 1 2 3 4 >
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5817684 Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke  
This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having...
5811421 Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods  
The present invention provides compounds of formula ##STR1## wherein R 1 is --H, --OH, --O(C 1 -C 4 alkyl), --OCOC 6 H 5 , --OCO(C 1 -C 6 alkyl), or --OSO 2 (C 4 -C 6 alkyl); R 2 is C...
5798354 Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment  
Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f):...
5614548 Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions  
Quaternary amine-containing ether lipid analogs of the formula R 1 --X--R 2 --N + (R 3 ) (R 4 ) (R 5 ) Z - are disclosed. R 1 represents a hydrophobic group and R 2 represents the backbone...
5556864 α-ω-diarylalkane compounds serotonin-2 receptor agonists  
Compounds of formula (I): ##STR1## [wherein: R 1 is aryl; R 2 is hydrogen, alkyl, alkoxy, halogen or cyano; R 3 is a group of formula --B--NR 4 R 5 , where R 4 and R 5 are independently...
5554628 Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs  
The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## and wherein the variables are as defined in the...
5521180 Morpholine derivative  
A morpholine derivative represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R 1 and R 3 , which may be the same or different, each represent a hydrogen atom...
5510386 Aminosulfonylphenyl compounds for treating urinary incontinence  
Compounds of formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and A-B have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the...
5510344 Acrylate fungicides  
Compounds of formula I ##STR1## wherein X is oxygen or sulphur, W is CH or N, m is 0 or 1, and either a) n is 1 and Q is a non-aromatic heterocyclic ring of 3 to 10 ring atoms, containing one to...
5502053 HIV protease inhibitor compounds  
Compounds of formula ##STR1## are HIV protease inhibitors, and are synthesized via a novel route. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment...
5491140 Naphthyl tachykinin receptor antagonists to treat physiological conditions  
This invention provides methods of treating a physiological disorder associated with an excess of tachykinins in a mammal which comprises administering to a mammal in need of said treatment a...
5464836 Benzophenones having an antifungal activity  
A description follows of benzophenones having an antifungal activity and responding to the general formula (I): ##STR1## wherein: R 1 and R 2 , the same or different, represent C 1 -C 6 alkyl...
5462954 Substituted phenyl phenol leukotriene antagonists  
Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and...
5447930 Topical anesthetic compositions  
An improved, clear and non-greasy topical anesthetic for the relief of various skin irritations such as minor burns, insect bites, rashes and allergic reactions is prepared using pramoxine...
5424309 N-substituted acylamino acid compounds, process for their production and their use  
The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
5385892 Ethylamino phenyl ethers having antifungal activity  
The ethylamino phenyl ethers of the invention and compositions thereof are endowed with high activities as inhibitors of the growth of several species of pathogen fungi and are applied to plants or...
5344845 Compound and use of the same as medicine  
Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds...
5272144 Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use  
Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is...
5232686 Gastroprotective pharmaceutical preparations containing N-benzyl-N-((1S,5S)-6,6-dimethylbicyclo(3,1,1)-hept-2-ylethoxy-ethyl)-mo rpholinium salts  
A method of inhibiting peripheral blood circulation disorders or damage such as hemorrhagic lesions induced by gastrotoxic doses of substances such as alcohol or non-steroid, antiinflammatory...
5185334 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use  
Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also...
5118682 p-Hydroxy phenone derivatives and the use thereof  
p-Hydroxy phenone derivatives of the general formula I ##STR1## where R 1 , R 2 and R 3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R 1 , R 2 and R 3 are not...
5095021 Phenylalkylamines and fungicides containing these  
Phenylalkylamines of the formula ##STR1## where n is 5, 6, 7, 8 or 9, m is 1, 2 or 3, R 1 is methyl, halogen, substituted or unsubstituted aryl or substituted or unsubstituted phenoxy, and, when m...
5089251 Aromatic derivatives and their use as antimicrobial agents  
The present invention relates to aromatic derivatives of the formula: ##STR1## in which: n represents an integer between 2 and 10; R 1 and R 2 are identical or different and represent a...
5086054 Novel arylcycloalkanepolyalkylamines  
Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity...
5082840 Morpholine compounds and treatment  
A method for increasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal...
5071851 Fungicidal cyclohexylamines  
4-substituted cyclohexylamines of the formula ##STR1## where R is the group CR 1 R 2 R 3 , where R 1 , R 2 and R 3 are hydrogen, unsubstituted or substituted alkyl, alkoxy, alkylthio or...
5047432 Arylcyclobutylmethylamine therapeutic agents  
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R 1 and R 2 , which are the same or different, are H or an optionally substituted hydrocarbon group or R 1 ...
5039673 Aminocyclopentyl ethers and their preparation and pharmaceutical formulation  
Compounds are described of the formula (1) ##STR1## where: R 1 is a hydrogen atom or a methyl group; X is cis or trans --CHCH-- or --CH 2 CH 2 --, m is 2, 3 or 4 and n is 1; or X is trans...
5017579 Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure  
The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case.
5002974 Anesthetic/skin moisturizing composition and method of preparing same  
A long lasting, esthetically pleasing medicated skin care moisturizing composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent...
4960774 Cyclic amines and fungicides containing them  
Amines of the general formula I ##STR1## where n is an integer from 2 to 10, X is oxygen or sulfur, Z is oxygen or CH--R 5 , and R 1 , R 2 , R 3 , R 4 and R 5 are identical or different and are...
4933367 Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds  
This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments...
4894373 Antiestrogens and their use in treatment of menopause and osteoporosis  
Disclosed is a method for treating menopausal symptoms and treating and preventing osteoporosis, wherein a true antiestrogen is administered and estrogen is not. This treatment is effective for...
4880800 Aminocyclopentyl ethers and pharmaceutical formulation  
Compounds are described of the formula ##STR1## where: R 1 is --H or --CH 3 , n is 1, m is 2-4 and X is --CHCH-- or --CH 2 CH 2 --; Y is a saturated heterocyclic amino group, R 2 is...
4877812 1-(acetylaminophenyl)-2-aminopropanone derivatives and antidepressant compositions thereof  
The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of (a) the compounds of the formula ...
4845098 Saccharine salts of substituted hydroxypropylamines, compositions and use  
Fungicidal saccharine salts of substituted hydroxypropylamines of the formula ##STR1## in which R 1 is optionally substituted phenyl, phenoxy, phenylthio, phenylalkyl, phenoxyalkyl, or...
4839155 Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy  
Iodotamoxifen derivatives which are compounds of formula (3) ##STR1## wherein X represents 3- or 4- iodo and R 1 and R 2 , which may be the same or different, represent C 1 -3 alkyl, especially...
4829068 Treatment of disorders of the gastro-intestinal tract  
Diphenylmethanes of the formula I: ##STR1## wherein X and Y are each chlorine or bromine, o and p are O or 1, R 1 and R 2 are each alkyl groups containing from 1 to 3 carbon atoms or are joined...
4803227 Aminoalkyl ethers of phenols as anticancer agents for the breast and colon  
The use of (a) N,N-dialkyl-2-[(4-phenylmethyl)phenoxy]ethanamine and N-morpholino-2-[(4-phenylmethyl)phenoxy]ethanamine compounds and their salts, as anticancer agents, is described. These...
4792551 9-anthryloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents  
Compounds useful for treating inflammation, pain and swelling, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Y and Z are each...
4792570 3- and 4-biphenyloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents  
Compounds useful for treating inflammation, swelling and associated pain, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an...
4785006 Fungicidal compositions containing piperidine compounds and use  
The invention provides fungicidal compositions comprising as an active ingredient a compound having the general formula (I): ##STR1## or a stereoisomer thereof wherein X and Y are hydrogen, alkyl,...
4783460 Morpholine derivatives, compositions and medicinal uses  
Compounds of formula (I): ##STR1## or a salt thereof, in which W is phenyl optionally substituted by halogen or trifluoromethyl, or a benzofuran-2-yl group, R 1 is hydrogen or methyl, R 2 ...
4766119 Antispasmodic alkylated aminothioester derivatives  
4766116 Diaryl butyric acid derivative and pharmaceutical use thereof  
A diaryl butyric acid derivative having the general formula: ##STR1## wherein R 1 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 2 to 4 carbon...
4758564 Ether and thioether amines and their use as fungicides  
Amines of the general formula ##STR1## where A is alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenylalkyl or phenylalkenyl, X is oxygen or sulfur, B is an alkylene chain and R 1 and R 2 are each...
4725593 Method of treating smooth muscle spasm  
A new method of treating a patient suffering smooth muscle spasm comprises administering to the patient an effective amount of anti-spasmodic compound having the general formula: ##STR1## where R...
4707480 Method for stabilizing a detrusor muscle while increasing detrusor muscle strength  
A method for inhibiting unplanned or premature detrusor muscle contractions while at the same time increasing the force of contraction of the detrusor muscle is provided. The method comprises...
4692465 2-phenylethylamine derivatives  
Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R 1 and/or R 2 wherein...
4678780 Anti-spasmodic agents having a ring in the main chain  
A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where R, X, m, n and p are defined hereinbelow.
Matches 51 - 100 out of 178 < 1 2 3 4 >