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7354920 |
Aryl and heteroaryl morpholine derivatives
Compounds of formula (I)
wherein Rx is H; Ry is H or C 1 -C 4 alkyl; each Rz is independently H or C 1 -C 4 alkyl; X represents O; Y represents OH or OR; R is C 1 -C 4 alkyl; and Ar 1 ...
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7338953 |
Method of treating chronic fatigue syndrome
Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a...
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7323466 |
Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity
The present invention refers to chemical compounds of formula (I)
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1 ....
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7317011 |
Method of treating peripheral neuropathy
Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine,...
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7279478 |
Cathepsin cysteine protease inhibitors
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating...
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7256191 |
Materials and methods for the treatment of depression
The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7166601 |
Substituted diamine derivatives useful as motilin antagonists
The present invention relates to novel substituted diamine derivatives for the formula
wherein R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , A, Y and n are as described in the...
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7166595 |
Compounds, methods and compositions
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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7112586 |
Substituted diamine derivatives useful as motilin antagonists
The present invention relates to novel substituted diamine derivatives for the formula
wherein R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , A, Y and n are as described in the...
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7109198 |
Method for treating obesity
The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide...
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7098206 |
Pharmaceutically active morpholinol
Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and...
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7078402 |
Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof
The invention relates to novel aminothiol ester compounds having the general formula (I):
and to a method for preparing them and to their use in pharmaceutical compositions intended for use in...
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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6984652 |
Gyrase inhibitors
Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each...
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6964782 |
Stable hydrogen peroxide compositions, products and methods of use
Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable...
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6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
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6812229 |
Carbamate derivative and agricultural/horticultural fungicide
It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
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6784175 |
Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments
The use of at least one substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compound and/or one of the enantiomers thereof and/or one of the diastereomers thereof and/or one...
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6756375 |
10-Aryl-11h-benzo&lsqb b&rsqb fluorene derivatives and analogs for medicinal use
The invention provides for a non-steroidal compound having the formula wherein R e and ′R e are OH, optionally independently etherified or esterified; Z is —CH 2 — or —CH 2 CH 2 —; R...
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6734213 |
Pharmaceutically active morpholinol
Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and...
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6677338 |
Serotonin transport inhibitors
The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.
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6664254 |
Odor-eliminating composition
The present invention relates to odor eliminating compositions, including air fresheners, and methods of eliminating odors. The inventive compositions comprise soyaethyl morpholinium ethosulfate,...
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6649616 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
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6638930 |
Morpholine and thiomorpholine tachykinin receptor antagonists
Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium...
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6599920 |
Naphthalene compounds, intermediates, formulations, and methods
This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.
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6586431 |
3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives
The present invention relates to compounds of the formula I, wherein Z 1 , Z 2 , X, Q, R 1 , R 2 and R 3 are defined as in the specification, pharmaceutical compositions containing such...
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6586427 |
Treatments for nervous disorders
This patent application describes the treatment of Addictive disorders, Psychoactive Substance Use disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco addiction and...
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6562817 |
Tricyclic compound
The present invention provides a compound of the formula (I): wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5-...
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6518265 |
1H-imidazopyridine derivatives
1H-Imidazopyridine derivatives represented by the following general formula or salts thereof: wherein R 1 represents hydrogen atom, hydroxyl group, an alkyl group, a cycloalkyl group, styryl...
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6489119 |
Analgesic screening method and composition
Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive...
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6479491 |
Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R 1 , R 2 , R 3 , R 4...
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6432982 |
Benzothiophenes, and formulations and methods using same
The invention provides novel benzothiophenes of the formula: wherein R 1 is —H, —OH, —O(C 1 -C 4 alkyl), —O—CO(C 1 -C 6 alkyl), —OSO 2 (C 4 -C 6 alkyl, or —OCOAr where Ar is...
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6395755 |
Benzothiophene pharmaceutical compounds
The present invention provides a compound of formula I wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH(C 1 -C 6 ...
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6391875 |
Pharmaceutically active morpholinol
Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them; also...
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6355632 |
Naphthyl compounds, intermediates, compositions, and methods
The present invention provides pharmaceutically active compounds formula I wherein R 1 is —H, —OH, —O(C 1 -C 4 alkyl), —OCOC 6 H 5 , —OCO(C 1 -C 6 alkyl), or —OSO 2 (C 2 -C 6 ...
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6352985 |
Benzimidazole compounds
A benzimidazole compound represented by the formula (I): wherein R 3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl...
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6211172 |
Methods and compositions for controlling biofouling using sulfonamides
The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one...
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6184222 |
Treatment of conduct disorder
Norepinephrine reuptake inhibitors are used to treat conduct disorder.
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6177067 |
Hair revitalizing tonic composition containing a 2,2-dimethylpropanediol compound and use thereof
Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula: ##STR1## wherein R 1 and R 2 are each independently a C 1 -30 hydrocarbon group...
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6153585 |
Arylsulfonanilide derivatives
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as...
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6121321 |
Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
Substituted methoxy benzylidene indenyl compounds are useful in the treatment of precancerous lesions and neoplasms.
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6046193 |
Treatment of attention-deficit/hyperactivity disorder
Reboxetine is used to treat attention-deficit/hyperactivity disorder.
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6028070 |
Treatment of oppositional defiant disorder
Norepinephrine reuptake inhibitors are used to treat oppositional defiant disorder.
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6008244 |
Halopropargyl compounds as marine antifouling agents
Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a halopropargyl quaternary ammonium compound, halopropargyl...
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6004959 |
Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using...
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6004958 |
Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention
The present invention is based on the discovery of a metabolic pathway in which a specific kinase converts fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction....
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5998442 |
Benzo [B] thiophene compounds, and compositions for treating bone loss, and hyperlipidemia
The invention provides benzo[b]thiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological...
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5952350 |
Naphthyl compounds and compositions, as estrogen receptor binding agents
The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of...
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5914351 |
Anti-viral aromatic hydrazones
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
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