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7365070 |
Modulators of melanocortin receptor
This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic...
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7129238 |
Mandelic acid derivatives
The invention is concerned with novel mandelic acid derivatives of formula (I)
wherein R 1 to R 10 , X and Y are as defined in the description and in the claims, as well as pharmaceutically...
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6849626 |
Aza-amino acid derivatives (factor Xa inhibitors 15)
The invention relates to semicarbazides of the general formula I
where R 1 , R 2 , R 3 , R 4 and I have the meaning indicated in claim 1.
The compounds of the formula I can be employed...
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6720319 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Het and X are defined herein. The...
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6703389 |
Method of treating chronic pain
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of...
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6638930 |
Morpholine and thiomorpholine tachykinin receptor antagonists
Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium...
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6552025 |
Diimino-piperazine derivatives for use as modulators of cell regulation
Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The...
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6525036 |
Compounds and compositions as protease inhibitors
The present invention relates to novel cysteine protease inhibitors of Formula I: the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and...
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6436933 |
Inhibitors of anthrax lethal factor activity
Methods and compositions that act as specific inhibitors of ALF activity for the prophylaxis and treatment of anthrax infections.
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6114323 |
Methods for inhibiting the advanced glycosylation of proteins
The present invention relates to methods for inhibiting protein aging. Accordingly, methods are disclosed for treating an animal to inhibit the formation of advanced glycosylation end products of...
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5972940 |
Arginine analogues having nitric oxide synthase inhibitor activity
A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and --NO 2 , E is --O-- or a...
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5885990 |
Substituted amidinonaphthyl ester derivative
Substituted amidinonaphthyl ester compounds effective for treatment of thrombosis are represented by the following formula (I) and pharmaceutically acceptable acid addition salts thereof: ##STR1##...
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5852009 |
Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the...
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5840725 |
Substituted oximes, hydrazones and olefins as neurokinin antagonists
Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3; b, d and e are independently 0, 1 or 2; R is H, C 1 -6 alkyl,...
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5612332 |
Di- and triaminoguanidines, and methods of use
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5523325 |
Amidrazones and their use as pesticides
This invention relates to amidrazones, insecticidal amidrazone compositions, and methods of using such compositions.
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5464832 |
Substituted 3-thioacryloyl compounds and their use as antimicrobial agents
A thioacryloyl compound of the formula ##STR1## wherein Z is selected from the group consisting of OR, R and NR 1 R 2 ; R is selected from the group consisting of hydrogen; (C 1 -C 18 )alkyl; (C...
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5281625 |
Fungicidal guanidines
Guanidines I ##STR1## (A=C 5 -C 12 -cycloalkyl which may bear up to three further substituents; benzyl substituted in the para-position; R 1 , R 2 , R 3 =H, C 1 -C 4 -alkyl; R 4 =C 5 -C 18 ...
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5268373 |
Guanidine derivatives, compositions and use
This invention relates to new heterocyclic derivatives of guanidine and more particularly to such derivatives which have hypoglycemic activity, their methods of use for treating hyperglycemia and...
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5082840 |
Morpholine compounds and treatment
A method for increasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal...
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5006523 |
Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.
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4837236 |
Fungicidal morpholine compounds, and their production and use
A heterocyclic compound of the formula: ##STR1## wherein A is an oxygen atom or a sulfur atom; B is either one of the groups: --CH 2 --CHR 1 -- or --CHCR 1 -- (in which R 1 is a hydrogen...
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4810725 |
1-aryloxy-3-(substituted aminoalkylamino)-2-propanols, pharmaceutical compositions and use
1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have β-adrenergic blocking activity with some cardioselectivity and hence are useful as...
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4797398 |
Morpholine compounds, compositions and use
A compound of formula (I): ##STR1## or a salt thereof; where Z represents a heterocyclic ring and R 2 and R 3 are independently selected from hydrogen, nitrile, CONH 2 and SO 2 R 4 where R 4 ...
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4731383 |
Aminoguanidine compounds, their compositions and pharmaceutical uses
The invention relates to new aminoguanidine derivatives of the general formula (I), ##STR1## wherein R 1 , R 2 and R 3 each represent hydrogen or halogen atom, C 1 -4 alkyl, nitro,...
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4719221 |
2-acetylpyrimidine-5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone and salts thereof
A class of novel thiosemiarbazones has been found to be active against a number of protozoa which cause serious diseases, mainly in the tropical areas of the world.
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4649138 |
Pharmaceutical compositions
S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
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4593039 |
1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have β-adrenergic blocking activity with some cardioselectivity and hence are useful as...
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4567174 |
Bis(1-substituted biguanide) derivatives
A bis(1-substituted biguanide) derivative of the formula: R 3 R 4 N.C(:NR 5 )NH.C(NR 9 )NR 1 --X--NR 2 .C(:NR 9 )NH.C(:NR 6 )--NR 7 R 8 V or a tautomeric form thereof, wherein R 1 , R 2 and...
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4539319 |
Amidine derivatives
Compounds of formula (I) ##STR1## and acid addition salts thereof, wherein R 1 is hydrogen, hydroxy, alkoxy, aryloxy, aralkoxy, heteroaryloxy or heteroaralkoxy; and one of R 2 , R 3 and R 4...
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4491595 |
Combating fungi with trisubstituted cyanoguanidines
Trisubstituted cyanoguanidines of the formula ##STR1## in which R 1 represents an optionally substituted phenyl or phenylalkyl radical, an alkyl radical with more than 1 carbon atom, a substituted...
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4491586 |
Amine derivatives
The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof in which the substituents are defined in the...
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4486439 |
Treatment of coccidiosis
A method for the preventive and curative treatment of coccidial infections in humans and other animals comprising the administration thereto of an amidinourea of amidinothiourea.
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4464374 |
Substituted guanidine derivatives, processes, pharmaceutical compositions and methods and intermediates
The invention relates to a guanidine derivative of the formula: ##STR1## in which W is a 2-6C alkylene chain optionally substituted by 1 or 2 1-4C alkyls; E is O, S, SO, SO 2 or NR 3 in which R 3...
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4435398 |
Guanidine compounds
Compounds of the formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. The compounds are useful as anthelmintics.
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4432994 |
Pesticide compounds, compositions and methods
Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are...
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4372954 |
Moroxydine phenoxyisobutyrates and method of use
The moroxydine phenoxyisobutyrates of the present invention are characterized in that they correspond to the following general formula I: ##STR1## in which R represents a chlorine atom or a...
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4348406 |
Novel guanidine derivatives
Compounds of the formula: ##STR1## and their pharmaceutically acceptable acid addition salts, useful as anthelmintics are disclosed.
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4340609 |
Amidinourea derivative veterinary compositions for suppression of parasitemia
Therapeutic compositions containing an amidinourea are used in the treatment of animals infested with blood residing parasites, particularly parasitic protozoal infestations of the blood and...
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4333929 |
Carboxamidine derivatives and hypoglycemical use
A compound of formula (II) or a pharmaceutically acceptable acid addition salt thereof ##STR1## wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents C 1 -6 alkyl; R 5 ...
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4285972 |
Method of treating scours
Scours in animals, particularly new-born calves, lambs, piglets and foals are treated with a compound containing an effective amount of an antidiarrheal amidinourea.
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4277471 |
1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment
Biphenylylalkylamines which have anti-arrhythmic activity have been prepared. Pharmaceutical formulations containing such compounds and a method of treating cardiac arrhythmias are provided.
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4269837 |
Hypoglycemic guanylamidines, compositions and use
Novel guanylamidines and the pharmaceutically acceptable acid addition salts thereof having activity as hypoglycemic agents are disclosed.
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4241087 |
Dysmenorrhea treatment
Amidinoureas of the formula: ##STR1## when administered to females who suffer dysmenorrhea relieve discomfort and pain and prevent damage caused by abnormal uterine muscle spasms incident to...
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4205071 |
Pharmaceutical compositions having immunosuppressant activity and methods therefor
S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
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4204000 |
Anti-ulcer amidinoureas
A novel method of treating gastrointestinal, spasmolytic and ulcerogenic disorders by the administration of amidinoureas is disclosed.
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4139637 |
Quinone derivatives useful as medicaments
The present invention relates to new chemical compounds which are useful in particular as medicaments. The compounds are derivatives of a quinone endowed with physiological and particularly vitamin...
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4089957 |
Therapeutic compositions against recurrent thrombosis
Disclosed is (1) a method of resisting as well as suppressing recurrent venous thrombosis in a human susceptible to or having said thrombosis, which method comprises administering to said human a...
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4051242 |
Substituted N-acyl-N"-(3-amino-2-cyanoacryloyl-)formamidrazones
Therapeutically-active and pharmacologically-acceptable N-acyl-N" -(3-amino-2-cyanoacryloyl)-formamidrazones and their pharmaceutically-acceptable acid-addition salts inhibit xanthine oxidase and...
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