|
Match
|
Document |
Document Title |
|
|
7335681 |
Amino ceramide-like compounds and therapeutic methods of use
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of...
|
|
|
7279477 |
Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating...
|
|
|
7259158 |
Naphthaline derivatives as H3 inverse agonists
The present invention relates to compounds of formula I:
and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The...
|
|
|
7250415 |
1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors
The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives...
|
|
|
7250412 |
PH sensitive prodrugs of 2,6-Diisopropylphenol
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby...
|
|
|
7235552 |
Cholenic acid amides and pharmaceutical compositions thereof
Novel sterol derivatives of formula (I), in which: R 1 represents a hydroxyl group or protected hydroxyl group, R 2 represents a hydrogen atom and a double bond is present at c, or R 1 and R 2 ...
|
|
|
7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
|
|
|
7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
|
|
|
7199158 |
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula:
wherein R 1 –R 6 , R 7 , R 7′ , R 8 , R 30 –R 34 , X′, Y, Y′, t, x, and n are as defined herein, are...
|
|
|
7176201 |
Modulation of anxiety through blockade of anandamide hydrolysis
Fatty acid amide hydrolase inhibitors of the Formula:
are provided wherein X is NH, CH 2 , O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of...
|
|
|
7157457 |
Compounds useful in the treatment of inflammatory diseases
There are provided according to the invention, novel compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, a, b and Z are as defined in the specification, processes for...
|
|
|
7148251 |
Amino ceramide-like compounds and therapeutic methods of use
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of...
|
|
|
7148208 |
Pharmaceutical compositions for headache, migraine, nausea and emesis
S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of...
|
|
|
7144881 |
Arylcyclopropylcarboxylic amides as potassium channel openers
The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined...
|
|
|
7141560 |
Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics
The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I
The invention also relates to pharmaceutical compositions comprising said derivatives,...
|
|
|
7053087 |
Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics
Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in...
|
|
|
7034020 |
Derivatives of butyric acid and uses thereof
The present invention provides a series of compounds having structural formulas
wherein n 1 is 1 to 5, n 2 is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from...
|
|
|
7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
|
|
|
7022703 |
Acetylenic compound useful in treating inflammatory disorders
This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated...
|
|
|
7019003 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
|
|
|
7001905 |
Substituted diarylamines as MEK inhibitors
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C 1-6 alkoxy, or NR 6 OR 7 ; X is OR 12 , NR 13 R 12 , or NR 14 ; inhibitors of MEK and...
|
|
|
6972287 |
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound...
|
|
|
6949567 |
Compounds for the treatment of protozoal diseases
The invention relates to new diphenylurea having the formula (I)
or a salt thereof, where
Y is C═O, C═S, C═NH, (C═O) 2 or SO 2 ; and to processes for the preparation of these...
|
|
|
6911477 |
Muscarinic receptor agonists
This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or...
|
|
|
6897240 |
Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use
The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as...
|
|
|
6887871 |
Use of phenylheteroakylamine derivatives
There is disclosed the use of a compound of formula (I) wherein R 1 , R 2 , X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates...
|
|
|
6878707 |
Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
Compounds of formula (I) wherein R 2 —C, R 3 —C, R 4 —C or R 5 —C may be replaced by N; and wherein n is 1, 2 or 3; R 1 is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R 2 , R 3...
|
|
|
6872719 |
Phenylalanine enamide derivatives
Phenylalanine enamide derivatives of formula (1) are described:
wherein R 1 is a —CH 3 , —(CH 2 ) 3 CH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 , —CH 2 CH 2 OCH 2 CH 2 OH, —CH 2 CH 2...
|
|
|
6844366 |
Sulfonamide hydroxamates
This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for...
|
|
|
6831080 |
Cinnamide derivatives as KCNQ potassium channel modulators
There is provided novel cinnamide derivatives of Formula I: wherein R is C 1-4 alkyl or trifluoromethyl; R 1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl,...
|
|
|
6821973 |
Compounds
A compound having the general formula R 1 R 2 N—CH 2 CH 2 —CHAr 1 —CH 2 —NR 3 —CO—R 4 (I) and methods of using such compounds for the treatment of diseases and pharmaceutical...
|
|
|
6821965 |
Amidobenzamide derivatives which are useful as cytokine inhibitors
The invention concerns amide derivatives of the Formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy,...
|
|
|
6780858 |
Antibacterial agents
Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
|
|
|
6750217 |
Benzenesulfonamide derivatives and their use as MEK inhibitors
Benzenesulfonamides of formula (I), in which W is OR 1 , NR 2 OR 1 , NR A R B , NR 2 NR A R B , or NR 2 (CH 2 ) 2-4 NR A R B and the other variables as defined in the claims, are inhibitors of MEK...
|
|
|
6747027 |
Thiol sulfonamide metalloprotease inhibitors
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors,...
|
|
|
6743790 |
Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
The present invention relates to compounds of the formula I, in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, X, m and n have the meanings indicated in the claims. The compounds of the formula I...
|
|
|
6667309 |
Cyclobutene derivatives useful as antagonists of the motilin receptor
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin...
|
|
|
6664254 |
Odor-eliminating composition
The present invention relates to odor eliminating compositions, including air fresheners, and methods of eliminating odors. The inventive compositions comprise soyaethyl morpholinium ethosulfate,...
|
|
|
6649616 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
|
|
|
6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
|
|
|
6586432 |
Neurokinin-1 receptor antagonists
Compounds having the general formula R 1 R 2 N—CH 2 CH 2 —CHAr 1 —CH 2 —NR 3 —CO—R 4 (I) wherein R 1 , R 2 , R 3 , R 4 and Ar are as defined in the specification, methods of making...
|
|
|
6586431 |
3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives
The present invention relates to compounds of the formula I, wherein Z 1 , Z 2 , X, Q, R 1 , R 2 and R 3 are defined as in the specification, pharmaceutical compositions containing such...
|
|
|
6576628 |
3-aryl-succinamido-hydroxamic acids, methods for producing said acids and medicaments containing the same
The invention relates to inhibitors of matrix metalloproteases, more specifically a 3-aryl-succinamido-hydroxamic acid of formula (I) and its salt, ester and derivative thereof, along with...
|
|
|
6534499 |
N-substituted-N′-substituted urea derivatives and the use thereof as TNF-α production inhibitory agents
N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-α...
|
|
|
6511979 |
Methods for treating conditions modulated by lactosylceramide
The present invention includes methods for treatment and prophylaxis of conditions associated with lactosylceramide. The methods generally provide for administration to a mammal, particularly a...
|
|
|
6489119 |
Analgesic screening method and composition
Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive...
|
|
|
6482862 |
Method of using substituted N-benzyl-N-phenyl aminoalcohols for inhibiting cholesteryl ester transfer protein activity
The invention relates to use of substituted aromatic polycyclic tertiary-heteroalkylamine compounds as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and...
|
|
|
6479491 |
Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R 1 , R 2 , R 3 , R 4...
|
|
|
6476027 |
N-hydroxy 4-sulfonyl butanamide compounds
An N-hydroxy sulfonyl butanamide compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated N-hydroxy...
|
|
|
6462042 |
Hydroxamic acid derivatives as matrix metalloproteinase (mmp) inhibitors
Compounds having therapeutic utility are of formula (I) wherein B 1 , B 2 , R 1 and R 2 are each various sub-stituents, or R 1 and R 2 together form a ring.
|