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8916556 Pharmaceutical formulations comprising neurotrophin mimetics  
Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity...
8912177 Method of treating polycystic kidney diseases with ceramide derivatives  
A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural Formula (1): or a pharmaceutically...
8912185 Use of glutaric acid derivatives or the pharmaceutically acceptable salts thereof as anti-arrhythmic agents  
The invention relates to the use of glutaric acid derivatives of general formula (I), which are disclosed in the invention description, as anti-arrhythmic agents.
8895551 Acrylamide compounds and the use thereof  
The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the...
8877747 Indenone derivative and pharmaceutical composition comprising same  
An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising...
8802666 Inhibitors of cyclophilins and uses thereof  
The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2;A is in particular CH or N;X is in particular CO, SO2, CS, and R1 is in particular H,R2 is a group of formula...
8802673 Heterocyclic amine derivatives  
The present invention relates to compounds of formula I wherein A, B, X, Y, Ar, R1, R2, R′, m and n are as defined herein and to pharmaceutical active acid addition salts thereof, which have a...
8796298 Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chIoro-4-(4-chIoro- 1 -methyl- 1 H-pyrazol-5-yl)-2-10 thiophenecarboxamide useful in the treatment of cancer  
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method...
8669252 Prolylcarboxypeptidase inhibitors  
Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the...
8642623 Vanilloid receptor ligand compounds, pharmaceutical compositions containing them, a method of producing them and the use thereof to treat pain and various other conditions  
Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical compositions containing such compounds, a method for producing the compounds, and the use of such...
8642596 Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically...
8637567 Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid  
This invention provides compounds, compositions and methods for treating a cognitive disorder or memory disorder in animals that result from aging or other neurodegenerative condition. In...
8592419 Ceramides and apoptosis-signaling ligand  
The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for...
8530465 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof  
The invention provides a series of novel 1,2-disubstituted amido-anthraquinone derivatives. Further, the invention also provides the preparation method and application of said derivatives, said...
8394799 Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component  
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer...
8343971 Pharmacologically-active vanilloid carbamates  
This application relates to pharmacologically-active vanilloid compounds which are useful for the treatment of various anti-inflammatory states characterized by inhibition of FAAH, such as,...
8338413 Oxazine derivatives and their use in the treatment of neurological disorders  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their...
8309608 Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases  
The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of...
8299075 Substituted thiomorpholine derivatives  
The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
8252816 Vanilloid receptor ligand compounds, pharmaceutical compositions containing them, a method of producing them and the use thereof to treat pain and various other conditions  
Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical composition s containing such compounds, a method for producing the compounds, and the use of such...
8207164 Oxazine derivatives and their use in the treatment of neurological disorders  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their...
8202866 Ortho-aminoanilides for the treatment of cancer  
The present invention is directed to a compound of formula I, and processes for the manufacture of said compounds as well as medicaments containing said compound. The compounds according to this...
8163735 Sulfonamide compounds as cysteine protease inhibitors  
The present invention is directed to compounds of formula (I) that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases...
8080548 Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders  
The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System...
8053435 Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same  
The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.
7968601 Adamantyl acetamides as 11-β hydroxysteroid dehydrogenase inhibitors  
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently...
7834013 Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40  
The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates...
7812023 Methods of using substituted morpholine derivatives  
The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
7799778 5-substituted 2-aminopyridine analogs for treating allergic and inflammatory diseases  
Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically...
7795315 N-(2-amino-phenyl)-amide derivatives  
The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments...
7767666 Butyl and butynyl benzyl amine compounds  
Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or...
7763657 Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same  
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a...
7750049 O-substituted-dibenzyl urea-derivatives as TRPV1 receptor antagonists  
The invention relates to compounds of formula (I) in which R is selected from halogen, alkyl, alkoxy, aryl and heteroaryl; R1 is selected from 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl,...
7745438 3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors  
The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.
7635715 Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof  
Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the...
7632835 Substituted morpholine and thiomorpholine derivatives  
The present invention relates to morpholine and thiomorpholine derivatives or the general formula I or pharmaceutically acceptable salts thereof and their use.
7632836 Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders  
The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System...
7572790 Biphenyl carboxylic amide p38 kinase inhibitors  
Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
7544676 Sulfamoyl benzamides and methods of their use  
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the...
7544716 Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists  
This invention relates to tetrahydro-naphthalene derivatives of formula (I) in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms and...
7531538 α- and β-Amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors  
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
7528131 Substituted morpholinyl compounds  
This disclosure relates to novel substituted morpholinyl compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides...
7517880 Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas  
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
7501414 Substituted morpholine and thiomorpholine derivatives  
The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
7476672 Acetylenic compounds useful in treating inflammatory disorders  
This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated...
7452891 MCH antagonists and their use in the treatment of obesity  
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the...
7449463 Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication  
The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide,...
7429589 Mono-nitration of aromatic compounds via nitrate salts  
A method of nitrating a compound selected from the group consisting of is provided.
7335681 Amino ceramide-like compounds and therapeutic methods of use  
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of...
7279477 Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators  
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating...
Matches 1 - 50 out of 281 1 2 3 4 5 6 >