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7247628 Cannabinoid receptor ligands and uses thereof  
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
7223758 Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation  
The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its...
7211577 Water-soluble phenylpyridazine derivative and medicine containing the same  
A phenylpyridazine derivative represented by the formula (1): Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine...
7179806 Δ1-pyrrolines used as pesticides  
The invention relates to novel Δ 1 -pyrrolines of the formula (I) in which R 1 , R 2 , R 3 , m, and Q have the meanings given in the disclosure, to a plurality of processes for preparing these...
7122546 Imidazol-1-ylmethyl pyridazine derivatives  
The invention provides imidazol-1-ylmethyl pyridazine derivatives of the formula: that bind to GABA A receptors. In the above formula, R 1 , R 2 R 3 , R 4 , R 5 , R 6 and Ar are defined...
7064123 Compounds and compositions as cathepsin inhibitors  
The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
7041669 1,4-benzofused urea compounds useful in treating cytokine mediated diseases  
Disclosed are 1,4-disubstituted benzo-fused urea compounds of formula (I): wherein Ar, X, A, L, and Q of formula(I) are defined herein. The compounds inhibit production of cytokines involved in...
7030110 Cyclic oxyguanidine pyrazinones as protease inhibitors  
Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: wherein R 3 , R 4 , R 5 , W, and A are as set forth in the specification, as well as hydrates,...
6974810 4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity  
The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB 1 ) receptor antagonists with utility for the treatment of diseases connected...
6867206 6-carboxyphenyldihydropyridazinone derivatives and use thereof  
The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R 1 , R 2 , R 3 , A, D, G, and E are as defined in the specification and claims, a...
6852717 Compounds useful as anti-inflammatory agents  
Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
6833364 Substituted pyrazole derivatives  
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R 1 , R 2 , R 3 , A, X and Y are each as defined, and to processes...
6821971 Fused pyrazolone compounds which inhibit the release of inflammatory cytokines  
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
6730671 Compounds useful as reversible inhibitors of cathespin S  
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
6723742 Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators  
The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R 1 -R 5 are as defined in the description. The compounds have useful pharmaceutical properties and are...
6720317 Inhibitors of factor Xa  
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
6706711 Pyrazole derived kinase inhibitor  
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein R 1 , R 2 , T, n and Q are as described in the specification. The compounds are useful for...
6664256 Phenylpyridazine compounds and medicines containing the same  
Phenylpyridazine compounds represented by the following formula (I): are provided, wherein R 1 , R 2 , R 3 , R 4 , and n are as defined herein having excellent inhibitory activity against...
6660732 Compounds useful as anti-inflammatory agents  
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
6656933 Compounds useful as anti-inflammatory agents  
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
6608057 Compounds useful as reversible inhibitors of cathepsin S  
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
6586431 3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives  
The present invention relates to compounds of the formula I, wherein Z 1 , Z 2 , X, Q, R 1 , R 2 and R 3 are defined as in the specification, pharmaceutical compositions containing such...
6562817 Tricyclic compound  
The present invention provides a compound of the formula (I):   wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5-...
6548512 Nitrogen containing heteroaromatics as factor Xa inhibitors  
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and...
6537991 Method of treating a peripheral neuropathic pain  
The invention provides methods for treating and preventing neuropathic pain which comprise the administration of an effective amount of an antagonist of the pain-enhancing effects of E-type...
6525046 Aromatic heterocyclic compounds as antiinflammatory agents  
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar 1 ,Ar 2 ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases...
6472390 Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure  
Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a...
6413960 Substituted pyrazolyl benzenesulfonamides for the treatment of asthma  
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ...
6387900 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents  
3-ureido-pyrazole derivatives represented by formula (I): where R, R 1 and R 2 are as described herein, or pharmnaceutically acceptable salts thereof; are useful, for example, for the...
6348468 Pyridazine compounds and compositions containing the same  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R 1 represents a (substituted) aryl group, R 2 represents a phenyl group substituted at 4-position by a...
6333325 Method of treating cytokine mediated diseases or conditions  
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar 1 ,Ar 2 ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases...
6319921 Aromatic heterocyclic compound as antiinflammatory agents  
Disclosed are novel aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating...
6306841 Treatment of female sexual dysfunction  
Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina,...
6300356 Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist  
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
6271237 Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors  
The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms...
6271230 Use of NK-1 receptor antagonists for treating cognitive disorders  
The present invention provides methods for the treatment or prevention of cognitive disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor...
6218376 Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists  
Compounds of formula I or salts thereof ##STR1## where for example Y is a group of the formula (i) ##STR2## and R 1 is a group of formula (ii) ##STR3## are provided along with compositions...
6200979 Methods of administering CRF antagonists  
Substituted pyrrazoles of the formula ##STR1## wherein R 1 , R 2 , R 3 , X, Y, Z and A are as defined herein with reference to formula I; pyrazoles and pyzazolopyrimidines of the formula ##STR2##...
6121251 Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides  
Compounds with fungicidal and insecticidal properties having formula I ##STR1## wherein W is ##STR2## n is 0 or 1; Y is O, S, NR 1 , or R 6 ; the ring bond containing R 4 and R 5 is a single...
6100259 Cannabinoid receptor modulators  
Novel pyrazole derivatives are provided which are cannabinoid receptor modulators. ##STR1##
6100258 Aromatic amine compounds that antagonize the pain enhancing effects of prostaglandins  
Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R 3 )N(R 2 )B--R 1 and --OD groups...
5981526 Use of tachykinin antagonist and rizatriptan  
The present invention relates to a method for the treatment or prevention of migraine, which method comprises administration to a patient in need of such treatment an amount of a tachykinin...
5977156 Fungicidal pyrazoles  
Method for protecting plants against fungal or bacterial attack, which comprises applying a 1-phenyl-pyrazole or 1-(2-pyridyl)pyrazole.
5972976 Aminostilbazole derivative and medicine  
The invention relates to an aminostilbazole derivative of the following formula or a hydrate thereof, and a salt thereof. ##STR1## wherein R 1 and R 2 each represents hydrogen etc.; R 3 , R 4 , R...
5968934 Morpholine derivatives and their use as therapeutic agents  
The present invention relates to compounds of formula (I) ##STR1## wherein X is a 5- or 6-membered C-linked heteroaromatic ring containing 1 to 4 nitrogen atoms and optionally containing in the...
5942249 Composition for oral administration containing pyridazinone compounds  
A composition for oral administration which contains a pyridazinone compound of the formula (I) ##STR1## wherein R 1 , R 2 and R 3 are each independently a hydrogen atom or a lower alkyl, X is a...
5837708 Sulphonamides  
Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders...
5763448 Pyrmidine derivatives  
A class of substituted pyrimidine derivatives are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system, in particular...
5756529 Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies  
A method of using pyrazolyl benzenesulfonamide compounds in treating inflammation and inflammation-related disorders in companion animals is disclosed.
5643908 Collagenase inhibitor  
Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have...
Matches 1 - 50 out of 153 1 2 3 4 >