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7595314 |
Benzoyl-piperazine derivatives
A compound of formula
wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia,...
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7592338 |
Pyrazole-amine compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where W, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7572794 |
Anthranilamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
The invention relates to novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors, their production and use as pharmaceutical agents for preventing or treating diseases that are...
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7566735 |
Compounds which potentiate AMPA receptor and uses thereof in medicine
Compounds of formula (I) and salts are provided:
along with pharmaceutical compositions, uses in medicine, e.g., treating disease or condition mediated by a reduction or imbalance in glutamate...
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7566709 |
1,3,4-Substituted pyrazoles as 5-HT receptor antagonists for the treatment of psychoses and neurological disorders
Compounds of the formula (I) and salts and solvates thereof, in which X, R 1 , R 2 , R 5 and Q have the meanings indicated in Claim 1 , are suitable as ligands of 5 HT receptors; as well as...
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7531670 |
Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives
Methods for treating cognitive/attention deficit disorders in general using tetrahydroindolone derivatives and analogues, particularly tetrahydroindolone derivatives or analogues in which the...
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7524838 |
Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them
The present invention relates to the novel derivatives of formula (I) in which
A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7)...
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7494990 |
2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
The compounds of a certain formula (1),
in which R1, R2, R3 and R9 have the meanings as given in the description, are novel effective PDE4 inhibitors.
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7470689 |
4-benzimidazol-2-ylpyridazin-3-one derivatives
Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R 1 and R 2 are detailed in the description, and the physiologically tolerated salts...
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7462613 |
Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
The present invention relates to novel pyridazinone derivatives of the general formula (I)
wherein
A is A1 or A2;
R is unsubstituted or at least monosubstituted C 1 -C 10 -alkyl, aryl,...
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7435728 |
Pyrazole derivatives
This invention relates to pyrazole derivatives of formula (I)
or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to...
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7247628 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
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7223758 |
Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation
The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined
herein, pharmaceutical composition thereof, process for its preparation, and its...
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7211577 |
Water-soluble phenylpyridazine derivative and medicine containing the same
A phenylpyridazine derivative represented by the formula (1):
Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine...
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7179806 |
Δ1-pyrrolines used as pesticides
The invention relates to novel Δ 1 -pyrrolines of the formula (I)
in which R 1 , R 2 , R 3 , m, and Q have the meanings given in the disclosure, to a plurality of processes for preparing these...
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7122546 |
Imidazol-1-ylmethyl pyridazine derivatives
The invention provides imidazol-1-ylmethyl pyridazine derivatives of the formula:
that bind to GABA A receptors. In the above formula, R 1 , R 2 R 3 , R 4 , R 5 , R 6 and Ar are defined...
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7064123 |
Compounds and compositions as cathepsin inhibitors
The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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7041669 |
1,4-benzofused urea compounds useful in treating cytokine mediated diseases
Disclosed are 1,4-disubstituted benzo-fused urea compounds of formula (I):
wherein Ar, X, A, L, and Q of formula(I) are defined herein. The compounds inhibit production of cytokines involved in...
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7030110 |
Cyclic oxyguanidine pyrazinones as protease inhibitors
Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I:
wherein R 3 , R 4 , R 5 , W, and A are as set forth in the specification, as well as hydrates,...
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6974810 |
4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity
The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB 1 ) receptor antagonists with utility for the treatment of diseases connected...
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6867206 |
6-carboxyphenyldihydropyridazinone derivatives and use thereof
The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula
wherein R 1 , R 2 , R 3 , A, D, G, and E are as defined in the specification and claims, a...
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6852717 |
Compounds useful as anti-inflammatory agents
Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6833364 |
Substituted pyrazole derivatives
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R 1 , R 2 , R 3 , A, X and Y are each as defined, and to processes...
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6821971 |
Fused pyrazolone compounds which inhibit the release of inflammatory cytokines
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
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6730671 |
Compounds useful as reversible inhibitors of cathespin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
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6723742 |
Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R 1 -R 5 are as defined in the description. The compounds have useful pharmaceutical properties and are...
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6720317 |
Inhibitors of factor Xa
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
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6706711 |
Pyrazole derived kinase inhibitor
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein R 1 , R 2 , T, n and Q are as described in the specification. The compounds are useful for...
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6664256 |
Phenylpyridazine compounds and medicines containing the same
Phenylpyridazine compounds represented by the following formula (I): are provided, wherein R 1 , R 2 , R 3 , R 4 , and n are as defined herein having excellent inhibitory activity against...
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6608057 |
Compounds useful as reversible inhibitors of cathepsin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
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6586431 |
3,3-Biarylpiperidine and 2,2-biarylmorpholine derivatives
The present invention relates to compounds of the formula I, wherein Z 1 , Z 2 , X, Q, R 1 , R 2 and R 3 are defined as in the specification, pharmaceutical compositions containing such...
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6562817 |
Tricyclic compound
The present invention provides a compound of the formula (I): wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5-...
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6548512 |
Nitrogen containing heteroaromatics as factor Xa inhibitors
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and...
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6537991 |
Method of treating a peripheral neuropathic pain
The invention provides methods for treating and preventing neuropathic pain which comprise the administration of an effective amount of an antagonist of the pain-enhancing effects of E-type...
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6525046 |
Aromatic heterocyclic compounds as antiinflammatory agents
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar 1 ,Ar 2 ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases...
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6472390 |
Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a...
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6413960 |
Substituted pyrazolyl benzenesulfonamides for the treatment of asthma
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ...
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6387900 |
3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
3-ureido-pyrazole derivatives represented by formula (I): where R, R 1 and R 2 are as described herein, or pharmnaceutically acceptable salts thereof; are useful, for example, for the...
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6348468 |
Pyridazine compounds and compositions containing the same
This invention relates to pyridazine derivatives represented by the formula (1): wherein R 1 represents a (substituted) aryl group, R 2 represents a phenyl group substituted at 4-position by a...
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6333325 |
Method of treating cytokine mediated diseases or conditions
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar 1 ,Ar 2 ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases...
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6319921 |
Aromatic heterocyclic compound as antiinflammatory agents
Disclosed are novel aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating...
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6306841 |
Treatment of female sexual dysfunction
Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina,...
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6300356 |
Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
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6271237 |
Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms...
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6271230 |
Use of NK-1 receptor antagonists for treating cognitive disorders
The present invention provides methods for the treatment or prevention of cognitive disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor...
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6218376 |
Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists
Compounds of formula I or salts thereof ##STR1## where for example Y is a group of the formula (i) ##STR2## and R 1 is a group of formula (ii) ##STR3## are provided along with compositions...
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6200979 |
Methods of administering CRF antagonists
Substituted pyrrazoles of the formula ##STR1## wherein R 1 , R 2 , R 3 , X, Y, Z and A are as defined herein with reference to formula I; pyrazoles and pyzazolopyrimidines of the formula ##STR2##...
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6121251 |
Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides
Compounds with fungicidal and insecticidal properties having formula I ##STR1## wherein W is ##STR2## n is 0 or 1; Y is O, S, NR 1 , or R 6 ; the ring bond containing R 4 and R 5 is a single...
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