|
Match
|
Document |
Document Title |
|
|
7629341 |
Human ADAM-10 inhibitors
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its...
|
|
|
7625895 |
Diphenyl-dihydro-imidazopyridinones
and the pharmaceutically acceptable salts and esters thereof, X, R 1 , R 2 , Y 1 and Y 2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti...
|
|
|
7618961 |
Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the...
|
|
|
7618960 |
Morpholine type cinnamide compound
The present invention relates to a compound represented by the formula (I):
or a pharmacologically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are the same or different and each...
|
|
|
7615550 |
Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists
The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the...
|
|
|
7605159 |
Cathepsin cysteine protease inhibitors and their use
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F,...
|
|
|
7601714 |
Pyrimidine derivatives useful as inhibitors of PKC-theta
Disclosed are novel compounds of formula (I):
wherein X, Y, R 1 , R 2 and R 3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of...
|
|
|
7595314 |
Benzoyl-piperazine derivatives
A compound of formula
wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia,...
|
|
|
7592450 |
Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) wherein t, R 1 , R 2 , L, Q, X, Y, Z and (a) have defined meanings, having histone deacetylase inhibiting enzymatic activity; their...
|
|
|
7589090 |
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds and methods for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist, the compounds being of formula (I):
wherein R 1 , R 2 , R 3 and R 4 are as defined herein.
|
|
|
7585858 |
N-sulfonylcarboximidamide apoptosis promoters
Compounds having the formula
are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
|
|
|
7579349 |
4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer
A compound of Formula (I); wherein the substituents are as defined in the text for use in modulating insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
|
|
|
7572921 |
Substituted benzylimidazoles useful for the treatment of inflammatory diseases
The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory...
|
|
|
7572793 |
3-Substituted-4-pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:
wherein R 1 represents...
|
|
|
7550462 |
Piperazinediones as oxytocin receptor antagonists
Compounds of formula (I)
wherein R 1 is 2-indanyl, R 2 is 1-methylpropyl, R 3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R 4 represents methyl and R 5 ...
|
|
|
7547702 |
4-amino-quinazolines
Quinazolines of the formula (I) in which R, R 1 , R 2 , R 3 , R 4 and Y have the meaning indicated in Patent claim 1 , and their salts or solvates as glycoprotein 1 bIX antagonists.
|
|
|
7544683 |
Cyclohexyl derivatives
The present invention relates to compounds of formula I
wherein R 1 and R 2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are...
|
|
|
7541359 |
N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
Certain N-heteroarylpiperazinyl urea compounds of Formula (I), as defined in the specification, are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical...
|
|
|
7531536 |
Pyrazole compounds useful as protein kinase inhibitors
This invention describes novel pyrazole compounds of formula IIIa:
wherein R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl,...
|
|
|
7531532 |
Pyridine derivative and pyrimidine derivative
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor...
|
|
|
7528135 |
Pyridine derivatives as H3 antagonists
The present invention relates to compounds of formula I
wherein R 1 , R 2 and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to...
|
|
|
7524845 |
Azaindazole compounds and methods of use
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in...
|
|
|
7507733 |
11b-HSD1 inhibitors for the treatment of diabetes
Compounds of the formula (I):
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1 can be used in the form of...
|
|
|
7504396 |
Substituted heterocyclic compounds and methods of use
The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell...
|
|
|
7501407 |
Pyrimidine A2B selective antagonist compounds, their synthesis and use
The subject invention provides compounds having the structure:
wherein R 1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5...
|
|
|
7494994 |
Phenylpyridylpiperazine compounds
A compound selected from those of formula (I):
wherein:
X represents a C(O) or SO 2 group, R 1 represents an aryl group or a group NR 3 R 4 wherein R 3 and R 4 are as defined in the...
|
|
|
7491732 |
Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
|
|
|
7488727 |
Thiazole compounds useful as inhibitors of protein kinase
The present invention provides a compound of formula I:
or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3,...
|
|
|
7485638 |
Pyrimidine compounds
Compounds of the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
|
|
|
7470686 |
Method of inhibiting the expression and/or the activity of JNK
The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said...
|
|
|
7465728 |
Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with CDK inhibitory activity
Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
|
|
|
7459452 |
Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
4,5-Dihydroxypyrimidine-6-carboxamides of formula:
are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R 1 , R 2 , R 3 and R 4 are defined herein. These...
|
|
|
7456175 |
Piperazinyl-pyridine derivatives
The present invention relates to compounds of formula I
wherein R 1 , R 2 , X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as...
|
|
|
7449456 |
Diaminopyrimidinecarboxamide derivative
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is...
|
|
|
7449462 |
Triazole derivatives which inhibit vasopressin antagonistic activity
Compounds of formula (I),
or pharmaceutically acceptable derivatives thereof, wherein:
Het represents 2-pyridinyl or 2-pyrimidinyl; R 1 represents H, C 1-3 alkyl or a...
|
|
|
7442699 |
Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure:
wherein R 1 ...
|
|
|
7442698 |
Substituted heterocyclic compounds and methods of use
The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I:
and pharmaceutically acceptable salts or derivatives thereof. Also included are methods...
|
|
|
7442697 |
4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity
Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
|
|
|
7435734 |
N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase
N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula:
are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R 1 , R 2 , R 3 and R 4 are defined...
|
|
|
7432255 |
1H-indol-5-yl-piperazin-1-yl-methanone derivatives
The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein in formula I is:
wherein R 1 to R 4 are as defined in the description and claims....
|
|
|
7432260 |
Pyrimidine compounds
The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs)...
|
|
|
7427612 |
Benzoyl-piperazine derivatives
A compound of formula
wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia,...
|
|
|
7427626 |
2-Anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk (cdk2) inhibitors
Compounds of the formula (I), and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Also described are processes for their preparation and their use as...
|
|
|
7414047 |
Piperazinyl and diazapanyl benzamides and benzthioamides
Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
|
|
|
7384943 |
Substituted chroman derivatives
The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I)
wherein
X is N; Y is NR 2 CH 2 , CH 2 NR 2 , NR 2 CO, CONR...
|
|
|
7378108 |
Percutaneous absorption preparation of compound having angiotensin II antagonistic activity
The present invention provides a percutaneous absorption preparation which comprises a compound having angiotensin II antagonistic activity and which allows the compound to permeate through the...
|
|
|
7365069 |
Pyrimidone derivatives
The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
|
|
|
7351708 |
Pyrrolo [2,3-b] pyridine derivatives
The present invention relates to compounds of formula I
wherein R 1 to R 4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are...
|
|
|
7351700 |
Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors
The present invention relates to compounds of formula
wherein
X is —S— or —NH—; R 3 /R 4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7...
|
|
|
7348323 |
Pyrrolo [2,3-c] pyridine derivatives
The present invention relates to compounds of formula I
wherein R 1 to R 4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are...
|