Match Document Document Title
9034850 Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same  
Disclosed are compounds useful as gonadotrophin-releasing hormone (“GnRH”) receptor antagonist.
9012461 FAK inhibitors  
A compound of the formula (I): where R1 or R2 is a cyclc amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.
9006232 Pyrimidone derivatives  
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom...
9006243 HIV inhibiting 6-substituted pyrimidines  
HIV replication inhibitors of formula R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl;R2, R3, R6 and R7 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy;...
8993567 Cyclic protein tyrosine kinase inhibitors  
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated...
8993565 (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors  
The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB)...
8987261 Substituted dihydropyrazolones for treating cardiovascular and hematological diseases  
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the...
8980890 Compositions and methods of treating cell proliferation disorders  
The invention relates to compounds and methods for treating cell proliferation disorders.
8975249 Heterocyclic compounds and uses thereof  
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
8969336 Diamino heterocyclic carboxamide compound  
Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against...
8969335 Benzonitrile derivatives as kinase inhibitors  
Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and...
8962622 Benzotriazole kinase modulators  
Compounds of formula I modulate jnk and cdk: or a pharmaceutically acceptable salt thereof, where R, R1, R2, R3, and m are defined herein.
8962609 Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them  
C Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1: in which: R1 represents...
8957073 Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors  
Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are...
8957068 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH  
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a...
8946218 CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments  
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases...
8940738 Pyrimidone compounds  
A pyrimidone derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents hydrogen atom and Y represents hydroxyl group, or X represents...
8927547 Pyrimidine derivatives  
The invention provides novel pyrimidine derivatives of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such...
8927009 ABT-263 capsule  
A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that...
8927525 Aminopyrimidine kinase inhibitors  
Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the...
8927546 Therapeutic piperazines  
The invention includes a compound of formula I: wherein R1, Y, A, n, R4 and Z have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds,...
8921336 Small molecule myristate inhibitors of BCR-ABL and methods of use  
The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds...
8916554 Amino-derivatives as novel inhibitors of histone deacetylase  
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their...
8916553 Sulfonamide compounds useful as CYP17 inhibitors  
Disclosed are sulfonamide compounds of Formula (I): or stereoisomers, N-oxides, prodrugs, or pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4 and R5 are defined herein....
8912182 Viral polymerase inhibitors  
Compounds of formula I: wherein X, R2, R3, R3a, R3b, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
8906916 Pyrimidine derivatives as FAK inhibitors  
Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumors.
8906917 Pyrimidine cyclohexyl glucocorticoid receptor modulators  
The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
8906914 Ethylene diamine modulators of fatty acid hydrolase  
Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of...
8906915 Compounds, compositions, and methods for controlling biofilms  
The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to...
8906906 Viral replication inhibitors  
The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also...
8901120 Substituted N-phenylpyrimidin-2-amine analogs as inhibitors of the Axl kinase  
In one aspect, the invention relates to substituted N-phenylpyrimidin-2-amine analogs, derivatives thereof, and related compounds, which are useful as inhibitors of Axl kinase; synthetic methods...
8898047 Methods for identifying inhibitors against viruses that use a class I fusion protein  
The invention concerns the generation of a three dimensional model of the six helix bundle (6HB) complexed with an inhibitor and the use of that model to identify, screen and/or develop inhibitors...
8883785 Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof  
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of...
8877745 CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments  
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) wherein HET is a group selected from among formulas (IIa) (IIb) (IIc) (IId) and their use for...
8871210 Chemokine receptor antagonists and use thereof  
The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the...
8865714 Piperazine compound capable of inhibiting prostaglandin D synthase  
This invention relates to a piperazine compound represented by Formula (I), wherein R1 is C1-6 alkyl;R2 is hydroxy, C1-6 alkyl that may have one or more substituents, —(C═O)—N(R3)(R4), or...
8865712 Heterocyclic derivatives and their use in the treatment of neurological disorders  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof,...
8859534 2-carboxamide-7-piperazinyl-benzofuran derivatives  
The present invention relates to compounds of formula (I), wherein R1 is heteroaryl or heterocyclyl, optionally substituted;R2 is C1-4alkyl, heterocyclyl, C1-4alkylaryl, C1-4alkylheteroaryl,...
8859546 Picolinamide inhibitors of kinases  
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates...
8853205 Heteropyrrole analogs acting on cannabinoid receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects...
8853199 Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors  
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided...
8835430 2,4-pyrimidinediamine compounds and their uses  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
8835419 Substituted anilines as CCR(4) antagonists  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
8828999 Pyrimidine compounds and their uses  
Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical...
8828996 Morpholine-spirocyclic piperidine amides as modulators of ion channels  
The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the...
8822464 N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors  
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the...
8822451 Modulators of ATP-binding cassette transporters  
4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof,...
8815856 Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione  
Disclosed are crystalline forms of (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethy l-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methy lpropyl]-2,5-piperazinedione...
8809331 Aminopyrimidine derivatives as LRRK2 modulators  
Specific Compounds of formula I: or pharmaceutically acceptable salts thereof,wherein m, X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and...
8802672 Pyrimidinyl-piperazines useful as D3/D2 receptor ligands  
The present invention relates to new dopamine D3 and D2 ligands of formula (I): wherein R1, R2 and Q are as described herein, and/or geometric isomers and/or stereoisomers and/or diastereomers...