Matches 251 - 300 out of 474 < 1 2 3 4 5 6 7 8 9 10 >
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5580868 Pyridyloxy-acrylic acid esters  
Novel pyridyloxy-acrylic acid esters of the formula ##STR1## in which Ar represents optionally substituted aryl or represents optionally substituted heteroaryl, a process for preparing the novel...
5563142 Diaromatic substituted compounds as anti-HIV-1 agents  
The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus.
5561130 Azacyclic compounds  
Compounds of Formula (I), and salts and prodrugs thereof, wherein n is 1, 2 or 3; X represents O or S; R 1 is optionally substituted phenyl; R 2 is aryl or heteroaryl; R 4 and R 5 are...
5561146 Modified guanidino and amidino thrombin inhibitors  
Thrombin inhibitors are provided which have the formula ##STR1## wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; and R 1 is cyano, hydroxyl,...
5545655 Substituted oxathiolanes  
This invention relates to novel imidazole and triazole substituted oxathiolane compounds and compositions containing said compounds having fungicidal and plant growth regulant activity and methods...
5521179 Heterocyclic amides  
The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also...
5514815 Succinimide derivatives and process for preparing the same  
Novel succinimide derivatives of formula I!: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R 1 and R 2 combine each other to form a group of the formula: >N--R 3 or one of R 1 and R 2...
5512567 Analgesic compounds, their preparation, and pharmaceutical compositions containing them  
Analgesic compounds of the formula (I); ##STR1## in which, R 1 and R 2 each represents hydrogen or C 1 -C 6 alkyl, or R 1 and R 2 together with the nitrogen atom to which they are attached...
5512570 Treatment of emesis with morpholine tachykinin receptor antagonists  
Substituted heterocycles of the structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma, emesis and nausea.
5500424 Pyrimidine and pyridine derivatives, their production and use  
The present invention relates to a compound represented by the general formula (I): ##STR1## [wherein R 1 is a lower alkyl group or the like, R 2 is a lower alkyl group or the like, R 3 and R 4...
5496830 Inhibition of hemoflagellates by camptothecin compounds  
Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans.
5489583 2-substituted 3-(4-amidinophenyl)propionic acid derivatives  
2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula ##STR1## in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The...
5468746 Compounds active on the cardiovascular system  
Compounds of the formula ##STR1## (wherein Ar, R, R 1 , R 2 , R 3 , R 4 , R 5 , m and n have the meanings given in the description), their preparation and pharmaceutical compositions containing...
5455246 Piperidine derivatives  
Compounds of formula I, Ia or Ib and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a...
5447929 Method of treating joint disorders using hydroxamic derivatives  
Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint...
5420155 Tetramic acid derivatives  
A class of 4-hydroxy-2(1H)-pyrrolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are...
5405845 (Pyrrolidinyl)phenyl carbamate derivatives and use  
Novel (pyrrolidinyl)phenyl carbamates and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the carbamates and...
5385892 Ethylamino phenyl ethers having antifungal activity  
The ethylamino phenyl ethers of the invention and compositions thereof are endowed with high activities as inhibitors of the growth of several species of pathogen fungi and are applied to plants or...
5378707 Aryl-propyl-amines endowed with antifungal activity  
Aryl-propyl-aminic compounds having the following formula ##STR1## have high activity and are useful in the agricultural field as fungicides.
5373008 Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents  
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R 1 and R 2 are each aliphatic or cycloalkyl or NR 1 R 2 is an optionally substituted heterocyclic ring, R 3 is alkyl,...
5371086 Aminopyridine compounds  
An aminopyridine compound represented by the formula: ##STR1## wherein n represents 0 or 1; Z represents S, NCN or CHNO 2 ; R 1 represents --NR 3 R 4 , --NHNR 3 R 4 , --NHCONHR 3 or...
5362729 Dihydropyridine derivatives useful in antitumor therapy  
Compounds which are useful in anti-tumors therapy having the formula (I) ##STR1## wherein Het imidazole, A represents a direct linkage at the phenyl 4-position: R is hydrogen; one of R 3 and R 4 ...
5360804 Multicomponent agent or kit for preparing the sulpho-conjugated form of pyridino, pyrimidino or triazino N-oxide compounds and method of use  
Multicomponent agent or kit for preparing the sulpho-conjugated form of pyridino, pyrimidino or triazino N-oxide compounds and method of use. The present invention relates to a multicomponent agent...
5342838 Phenolic thioetheramides  
The present invention relates to phenolic thioetheramides of the formula ##STR1## wherein R 1 and R 2 are tert-alkyl or phenyl, Alk 1 and Alk 2 are alkylene; X is sulfur or oxygen, m is 0, 1,...
5338739 (Pyrrolidinyl)phenyl carbamates, compositions and use  
Novel (pyrrolidinyl)phenyl carbamates and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the carbamates and...
5332735 Compounds of N-benzoylpyroline  
Compounds of the general formula (I): ##STR1## where A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in the description. Medicinal products.
5332736 Anti-convulsant aroyl aminoacylpyrroles  
Aroyl aminoacyl pyrroles are pharmaceutically useful as anti-convulsants, which includes utility for the treatment of epilepsy.
5328906 0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same  
Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
5324733 Spirocyclic antipsychotic agents  
A class of spirocyclic piperidine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric disorders. The claimed...
5322844 Alkoxy-4 (1H)-pyridone derivatives, processes for the preparation thereof, and pharmaceutical compositions containing them  
The invention concerns new derivatives of certain alkoxy-4(1H)-pyridones, processes for preparing them, and pharmaceutical compositions containing them. The compounds of the invention are useful in...
5281614 Substituted 1,2,4-triazoles bearing acidic functional groups as angiotensin II antagonists  
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. ##STR1##
5278169 Method of treating or prevention of fibrillation of the heart  
A method for the treatment and prevention of fibrillation using one or more potassium channel activators. Also, disclosed is a process for the preparation of compounds of the formula ##STR1## and...
5276031 Method for treating renal disease  
The present invention relates to the use of renin inhibitors and to renin inhibitor compositions for prevention, treatment, inhibition or reversal of renal dysfunction or disease, especially renal...
5262413 Use of isoxazolin-3-one derivatives as antidepressants  
A method of treating depression comprising administering to a patient an effective amount of a compound of the formula (Ib): ##STR1## wherein R 1b is hydrogen, halogen, C 1 -C 4 alkyl, C 2 -C 4...
5262418 N-(4-piperidinyl) (dihydroxybenzofuran or dihydro-2H-benzopyran)carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula --CH 2 --CH 2 -- (a-1), --CH 2 --CH 2 --CH 2 -- (a-2),...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
5254543 Sulphonylbenzyl-substituted pyridones which are angiotension II receptor antagonists  
Sulphonylbenzyl-substituted pyridones can be prepared by reacting pyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted pyridones can be employed as active compounds in...
5224980 Sulfur containing diamides and antimicrobial use  
A compound of the formula ##STR1## in which R 1 and R 2 taken together, and R 3 and R 4 taken together, independently represent a polymethylene chain having 3 or 4 carbon atoms, or a...
5189054 3-amidoindolyl derivatives and pharmaceutical compositions thereof  
The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.
5189035 Fungicidal furanone derivatives  
The invention provides furanone derivatives of the general formula ##STR1## in which R 1 represents a halogen atom or an optionally substituted alkyl or alkoxy group, R 2 represents a halogen...
5185334 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use  
Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also...
5162345 Heterocyclic compounds and their preparation and pharmaceutical formulation  
Compounds are described of the formula: ##STR1## and physiologically acceptable salts thereof, in which R 1 -R 7 are defined hereinafter. The compounds represented by formula (I) reduce...
5140031 Pyranyl cyanoguanidine derivatives  
Novel compounds having the formula ##STR1## wherein ##STR2## are disclosed. These compounds have potassium channel activating activity and are useful, for example, as cardiovascular agents,...
5137886 Insecticidal compounds  
The invention provides insecticidally active compounds of formula (I): ##STR1## wherein X is nitrogen or carbon bearing a hydrogen atom; R 1 is a group of formula --S(O) n --Y, wherein Y is an...
5128340 Thiazole derivatives  
The invention relates to thiazole derivatives with the general formula I ##STR1## wherein R 1 is halogen, CF 3 , CN, NO 2 , OH or C 1 -C 6 alkoxy; R 2 is hydrogen, C 1 -C 6 alkyl, C 1 -C...
5128355 Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5118685 Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds  
Aminopropanol derivatives of the formula: ##STR1## where R 1 and R 2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6...
5116835 Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof  
Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof. The present invention relates to compounds of the formula I...
5104872 N-(substituted benzyloxy) imine derivatives and method of use thereof  
Compound of the general formula (I), which is useful as an agricultural and horticultural fungicide, an agricultural and horticultural fungicidal composition containing said compound, use of said...
5102882 Pyroglutamide derivatives  
Pyroglutamide derivatives have been found to be useful as nootropic agents for administration to humans and animals.
Matches 251 - 300 out of 474 < 1 2 3 4 5 6 7 8 9 10 >