Matches 201 - 250 out of 421 < 1 2 3 4 5 6 7 8 9 >
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5516784 Anti-HIV (AIDS) agents  
Compounds of formula ##STR1## wherein Ar, W, Z, Q, R 1 , U, and T are as set forth herein, are described. These compounds are active as agents against retroviruses and in particular against HIV.
5506227 Pyridine-substituted benzyl alcohols as leukotriene antagonists  
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
5506257 Aminocyclohexylamides for antiarrhythmic and anaesthetic uses  
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
5496844 Indole derivatives  
The present invention provides indole derivatives of the general formula: ##STR1## The indole derivatives of the invention have potent antiestrogen activity and are useful as drugs for the...
5489583 2-substituted 3-(4-amidinophenyl)propionic acid derivatives  
2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula ##STR1## in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The...
5475007 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof  
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease,...
5468742 8-vinyl- and 9-ethinyl-quinolone-carboxylic acids  
The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.
5457104 Quinolone- and naphthyridonecarboxylic acid derivatives  
The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and...
5447929 Method of treating joint disorders using hydroxamic derivatives  
Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint...
5428033 Saturated hydroxyalkylquinoline acids as leukotriene antagonists  
Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
5428036 Sertindole prodrugs, compositions and use  
Reaction products of sertindole with an acid or an activated acid, with formaldehyde alone, formaldehyde in the presence of an alcohol or an amine, or with an acyloxymethylene halide, and having...
5401766 Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof  
Aminoacid derivatives of the formula I ##STR1## A , n, R 1 , R 2 and R 3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these...
5401740 Carbostyril derivative  
The novel carbostyril derivative represented by the general formula (1) ##STR1## [in the formula, A, R 1 , R 2 and the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton...
5399559 Fungicidal indole derivatives  
The invention relates to fungicidal compositions which comprise a carrier and, as active ingredient, an indole derivative of the formula ##STR1## in which R is a substituted phenyl group; R 3 and...
5380722 Indole carboxamides  
Novel indole-carboxamides of the formula ##STR1## and their non-toxic pharmaceutically acceptable acid addition salts having remarkable anti-arrhytmic properties.
5373008 Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents  
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R 1 and R 2 are each aliphatic or cycloalkyl or NR 1 R 2 is an optionally substituted heterocyclic ring, R 3 is alkyl,...
5358949 Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives  
Carbostyril derivatives or salt thereof, including novel compounds, having activities for curing and/or improving arrhythmia. Some carbostyril derivatives having similar chemical structural formula...
5356907 1-cycloalkylpyridones as analgesics  
A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected...
5354749 Sulfonylbenzyl-substituted benzo- and pyridopyridones  
Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and...
5350747 Heteroaryl piperazine antipsychotic agents  
Compounds of the formula ##STR1## and pharmaceutical compositions comprising them, wherein R 1 , Z, X, W and Y are as defined below. The compounds are useful in the treatment of psychosis and anxiety.
5334589 Quinolone carboxylic acid--metal ion--acid complexes  
Compositions of a quinolone carboxylic acids useful for oral or parenteral administration to a human or veterinary patient are disclosed which comprise quinolone carboxylic acid--metal ion--acid...
5330997 1H-indazole-3-acetic acids as aldose reductase inhibitors  
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic...
5326760 Aminobutanoic acid compounds having metalloprotease inhibiting properties  
Aminobutanoic acids of the following formula (I): ##STR1## where R 1 -R 5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases,...
5318964 Hydroxamic derivatives and pharmaceutical compositions  
Hydroxamic acid derivatives of the formula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint...
5310744 Quinolylmethoxyphenyl-acetamides  
Quinolylmethoxyphenyl-acetamides of the formula: ##STR1## in which A, B, D, E, G, L and M are hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy...
5306719 Carbostyril derivatives and salts thereof  
Novel carbostyril derivatives and salts thereof having useful pharmacological activities such as myocardial contraction increasing activity (positive inotropic activity), coronary blood flow...
5304554 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation  
Novel 4-[(alkyl or dialkyl)amino]quinolines are disclosed that are prepared by condensin BACKGROUND OF THE INVENTION The United States government has rights in this invention as a result of a...
5296499 Indole derivatives, their production and use  
An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl...
5296478 1-substituted oxindoles as cognition enhancers  
Compounds of Formula I have been shown to enhance the release of the neurotransmitter acetlcholine, and thus may be useful as chemical intermediates and as pharmacological agents in the treatment...
5292736 Morpholinoalkylindenes as antiglaucoma agents  
Compounds of the formula ##STR1## wherein Alk is lower-alkylene; R 1 is hydrogen, lower-alkyl, Ar or ArCOO; R 2 is hydrogen or lower-alkyl; R 3 and R 4 are the same or different...
5270309 Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders  
4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of...
5270331 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides  
Antiinflammatory and analgesic oxindole prodrugs of the formula ##STR1## wherein R 10 , R 11 , R 12 and R 13 are hydrogen, alkyl or halogen and R is methyleneoxyalkanoyl, methyleneoxyalkenoyl or...
5268378 Dioxo-tetrahydroquinoline derivatives  
A class of 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are...
5266568 Hydroxyalkylquinoline ether acids as leukotriene antagonists  
Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
5254566 Decahydroquinoline compounds  
A compound selected from the group consisting of racemates, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein R 1 and R 2 are individually selected from the...
5250533 Fungicidal pyridinylpyrimidines  
Fungicidal pyridinylpyrimidines of the formula ##STR1## in which R 1 represents hydrogen, halogen, alkoxy, alkylthio, halogenoalkyl, amino or dialkylamino, where, in the case of dialkylamino, the...
5242939 Anilide derivatives with angiotensin II antagonist properties  
This invention relates to anilide derivatives of Formula I ##STR1## which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart...
5225413 pH-neutral aqueous solutions of quinolone-carboxylic acids  
A pH-neutral aqueous solution of a quinolonecarboxylic acid of the formula ##STR1## in which R 1 represents halogen, C 1 -4 -alkyl or C 2 -4 -alkenyl, R 2 and R 3 represent hydrogen, C 1 -4...
5223505 Pyrimidine derivatives  
This invention concerns novel aminopyrimidinium salts of the formula I: ##STR1## in which R 1 is alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl or cycloalkyl-alkyl; one of R 2 and R 6 is a...
5189054 3-amidoindolyl derivatives and pharmaceutical compositions thereof  
The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.
5182282 4-Benzyl-1H-indole derivatives  
Novel 4-benzyl-1H-indoles of the formula ##STR1## in all diastereoisomeric forms and mixtures thereof having anti-arhythmic activity.
5182275 Dihydro-4(hydroxyalkyeneamino)quinolines  
There are disclosed novel compounds of the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, nitro or trifluoromethyl; R 1 is hydrogen or loweralkyl; R 2 is...
5179093 Quinoline-diones  
Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein, R is H, halogen, (C 1 -C 6 ) alkyl, N(C 1 -C 6 alkyl/aryl) 2 , OH, O--(C 1 -C 6 ) alkyl/aryl, CH 2 OH,...
5179089 Isoquinoline compounds, compositions and use  
The invention relates to novel compounds of the general formula (I), ##STR1## wherein R means hydrogen or a straight or branched chain C 1 -6 alkoxy group; R 1 stands for hydrogen or a straight...
5177088 Substituted 3-(pyridinylamino)-indoles  
There are disclosed various compounds of the formula below, ##STR1## where R 1 , W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such...
5175002 Amantadine hydrochloride syspension with enhanced dissolution characteristics for use in soft gelatin capsules  
There are provided, novel no or low wax formulations for amantadine hydrochloride and methods for preparing such formulations.
5158959 Decahydroisoquinoline carboxylic acids  
What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds;...
5149702 Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same  
Provided are cycloheptenopyridine derivatives represented by the general formula ##STR1## [wherein R represents a hydrogen atom or lower alkyl group; R 1 represents a hydrogen atom, halogen atom,...
5124327 HIV reverse transcriptase  
Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds or pharmaceutical...
Matches 201 - 250 out of 421 < 1 2 3 4 5 6 7 8 9 >