Patents in Class 514/234.800

Matches 1 - 50 out of 59

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Match	Document	Document Title
1	7329659	Substituted-1-phthalazinamines as vr-1 antagonists The present invention provides a compound of formula (I): in which Ar and R 1 are phenyl or a heteroaromatic group, R 2 is generally hydrogen, R 3 is hydrogen or alkyl and X, Y and Z are...
2	7307078	Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
3	7125869	Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
4	7101879	Treatments for neurotoxicity in Alzheimer's Disease The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
5	7019003	Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided.
6	6984633	Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor...
7	6972288	4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases The present invention relates to bicyclic heterocycles of general formula wherein R a to R d , A to G and X are defined as in claim 1, the tautomers, the steroisomers and the salts...
8	6924285	Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them The present invention relates to bicyclic heterocyclic groups of general formula wherein R a , R b , R c , R d and X are defined as in claim 1, the tautomers, the stereoisomers, the...
9	6730671	Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
10	6677333	2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description)...
11	6632813	6-subtituted-7-heteroquinoxalinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both The invention provides compounds with antagonism against excitatory amino acid receptors, in particular, AMPA receptor having 6-substituted-7-heteroquinoxalinecarboxylic acid derivatives and...
12	6617329	Aminoquinazolines and their use as medicaments Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the...
13	6608057	Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
14	6562830	Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
15	6410536	Quinoxalinones as serine protease inhibitors such as factor XA and thrombin This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically...
16	6376490	Quinoxalinediones The invention provides compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R is a 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is...
17	6369057	Quinoxalines, processes for their preparation and their use Compounds of the formula I or Ia in which n and the substituents R 1 , R 5 and x have the meaning mentioned have an antiviral activity.
18	6339089	Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same A pyrimidine nucleus-containing compound represented by the formula (I): wherein ring A represents the ring of the formula (a): in which R 1 is a nitro group, an amino group, a substituted...
19	6288065	Quinoxaline-carboxylic acid derivatives The disclosure relates to quinoxaline derivates of Formula I ##STR1## wherein R 1 , R 4 , R 5 , R 6 , R 7 and R 8 are defined in the disclosure, as well as their production and use in...
20	6245760	Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56 lck tyrosine kinase activity, to pharmaceutical compositions comprising these...
21	5948775	2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones This invention relates to 2- or 3-(substituted aminoalkoxyphenyl)quinazolin-4-ones which are partial estrogen agonists and are useful in treating osteoporosis, prostatic hypertrophy, breast cancer...
22	RE36256	Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of...
23	5912245	Acid amide derivatives and process for the preparation thereof The present invention is directed to an acid amide of the formula ##STR1## wherein R 1 represents hydrogen or nitro, R 2 and R 3 stand for, independently from each other, hydrogen, lower...
24	5852016	Quinoxaline derivatives useful in therapy Compounds of formula (I), wherein A represents N or CH; R 1 and R 2 independently represent C 1 -4 alkyl, halo or CF 3 ; R 3 represents C 1 -4 alkyl (optionally substituted), C 3 -7 cycloalkyl,...
25	5837708	Sulphonamides Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders...
26	5783572	Quinoxalinedione NMDA receptor antagonists Compounds of formula (I): ##STR1## and their pharmaceutically acceptable salts, wherein R 1 and R 2 are each independently Cl, Br, CH 3 , CH 2 CH 3 or CF 3 ; R 3 is H, CH 3 or CH 2 CH 3 ;...
27	5773444	Quinazolines as inhibitors of endothelin converting enzyme Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated...
28	5441959	Substituted quinazolinones bearing acidic functional groups as angiotensin II antagonists Novel substituted quinazolinones of the formula (I) are useful as angiotensin II antagonists. ##STR1##
29	5434150	Condensed 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical preparations containing these compounds The invention relates to cyclic imino derivatives of general formula ##STR1## wherein A to G, R 1 , Z 1 to Z 6 , X and Y are defined as in claim 1, the tautomers, stereoisomers and mixtures...
30	5409926	AT-2 antagonist inhibition of vascular restenosis Novel disubstituted 6-aminoquinazolinones of the Formula ##STR1## are useful as angiotensin-II receptor (subtype 2) antagonists (AT 2 antagonists) alone or in combination with heparin, and can act...
31	5401745	Quinazolinones substituted with phenoxyphenylacetic acid derivatives Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as...
32	5380719	Quinoxaline biphenyl angiotensin II inhibitors Angiotensin II inhibition is exhibited by ##STR1## wherein: X is --CH 2 -- or O; R is hydrogen, alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl; R 1 and R 2 are each independently O...
33	5312820	Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT 1 and AT 2 activity useful in the treatment of hypertension and...
34	RE34201	N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds This invention pertains to novel substituted N/aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic...
35	5017579	Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case.
36	4987135	Substituted benzene derivatives, processes for their production and antitumor compositions containing them A substituted benzene derivative represented by a formula: ##STR1## where A represents: ##STR2## wherein X is a hydrogen atom, a halogen atom or a nitro group, R 1 is --X 1 Z 1 (X 1 is an...
37	4937337	Substituted heterocyclic compounds and the pharmacologically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them The present invention provides compounds of the general formula: ##STR1## wherein R 1 is a straight-chained or branched C 1 -C 12 -alkyl radical which can be substituted by a phenyl, naphthyl or...
38	4923864	Certain heterocyclic-hexanamides useful for treating hypertension Simple amides and derivatives thereof useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
39	4745118	Substituted quinazoline-3-oxides providing pharmacological activity Novel substituted quinazoline-3-oxides are disclosed as are methods of increasing cardiotonic activity and bronchodilation in which an unit dose of a composition containing an effective amount of a...
40	4684652	Pharmaceutical compositions containing naphthalene-and azanaphthalene-carboxamide derivatives, new naphthalene-and azanaphthalene-carboxamide derivatives and process for their preparation Compounds of the formula: ##STR1## in which R 1 is C 1 -6 alkyl, phenyl, C 3 -6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R 3 and R 4 being H or alkyl, R 5 being alkenyl or alkynyl,...
41	4647568	Circulation-active hydroxy-tetra-hydropyridinelactones Hydroxytetrahydropyridinelactones of the formula ##STR1## in which R represents a phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl,...
42	4628054	Stabilizing quinoxaline di-N-oxides against light degradation Quinoxaline di-N-oxides used in animal feeds, such as olaquindox, are stabilized against light degradation by substances which absorb light within the wavelength range from 200 to 450 nm, such as...
43	4600709	Benzodioxole derivatives, processes for the manufacture thereof and corresponding pharmaceutical compositions The invention relates to novel benzodioxole derivatives of the general formula I ##STR1## in which R 1 represents an unsubstituted or substituted, aliphatic, aromatic or heteroaromatic radical, ...
44	4517184	Benzodioxole derivatives The invention relates to novel benzodioxole derivatives of the formula I ##STR1## in which R 1 represents an unsubstituted or substituted, aromatic or heteroaromatic radical, alk represents an...
45	4489073	1,3,4-Thiadiazin-5-ones Heterocyclic compounds of the formula: ##STR1## wherein A is a direct link, or is alkylene of 1 to 4 carbon atoms or alkenylene of 2 to 4 carbon atoms; wherein either X is --CR 1 R 2 -- and Y is...
46	4418063	Growth promoting quinoxaline-di-N-oxide carboxamides Novel quinoxaline-di-N-oxide derivatives of the general formula ##STR1## in which R 1 is hydrogen or straight-chain or branched-chain alkyl having 1 to 4 carbon atoms, R 2 and R 3 ...
47	4414214	Benzodioxole derivatives and pharmaceutical use thereof The invention relates to novel benzodioxole derivatives of the formula I ##STR1## in which R 1 represents an unsubstituted or substituted, aromatic or heteroaromatic radical, alk represents an...
48	4409219	Quinoxaline-1,4-dioxide fodder suppliments The invention relates to new quinoxaline-1,4-derivatives of the general formula (I) and biologically acceptable salts thereof, ##STR1## wherein Q is a hydrogen atom or a methyl group, R 1 ...
49	4333931	Method of combatting harmful microorganisms using quinoxaline compounds Novel quinoxaline-di-N-oxide derivatives of the general formula ##STR1## in which R 1 is hydrogen or straight-chain or branched-chain alkyl having 1 to 4 carbon atoms, R 2 and R 3 ...
50	4296114	3,4-Dihydro-3-oxopyrido[2,3-b]-pyrazines, compositions and use thereof There are described compounds of formula I, ##STR1## in which R 1 is phenyl substituted by halogen, alkoxy, alkyl, carboxy-alkyl, --NR 4 R 5 , carboxy or alkoxy carbonyl, R 3 is hydrogen,...

Matches 1 - 50 out of 59

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