|
Match
|
Document |
Document Title |
|
|
7390805 |
4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I
wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof,...
|
|
|
7388002 |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
Compounds represented by the formula:
A is (CH 2 ) n R 2 , —CH═CH 2 , CH 2 —CH═CH 2 , O(CH 2 ) n R 2 , CH(OH)CH 3 , CH(OH)CH 2 OH, CH 2 —CH(OH)CH 3 , CH 2 CH(OH)CH 2 OH, or...
|
|
|
7381719 |
Diaryl ethers as opioid receptor antagonist
A compound of the formula (I) wherein the variables X 1 to X 10 , R 1 to R 7 including R 3′ , E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer,...
|
|
|
7378423 |
Pyrimidine compound and medical use thereof
The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I]
wherein each symbol is as defined in the...
|
|
|
7378417 |
Pyrazolo-pyrimidine derivatives
The invention relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined in the description and to pharmaceutically acceptable salts thereof, to...
|
|
|
7378411 |
Substituted thienopyrimidinones as a mitotic kinesin inhibitor
The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7371753 |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
Disclosed are new dihydropteridinones of general formula (I)
wherein the groups R 1 to R 5 , R a to R c , W, Q 1 and Q 2 have the meanings given in the claims and specification, the isomers...
|
|
|
7371750 |
Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
|
|
|
7361662 |
Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
A compound of formula (I):
wherein:
R 1 , R 2 , R 3 , R 4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a pharmaceutically...
|
|
|
7348339 |
Imidazopyridine derivatives as kinase inhibitors
A compound of the formula
and physiologically acceptable salts and or N-oxides thereof wherein,
X 1 is N or CR 3 ; X 2 is N or CR 4 ; X 3 is N or CR 5 ; X 4 is N or CR 6 . with the proviso...
|
|
|
7342006 |
Substituted 8-heteroaryl xanthines
Selective antagonists of A 2B adenosine receptors like those of formula I are provide.
The compounds and compositions are useful as pharmaceutical agents.
|
|
|
7335655 |
8-heteroaryl xanthine adenosine A2B receptor antagonists
The present invention relates generally to compounds of formula (I):
wherein
X is a five or six-membered heteroaromatic ring, containing one to four heteroatoms, selected from nitrogen,...
|
|
|
7332486 |
Phosphodiesterase 4 inhibitors
PDE4 inhibition is achieved by novel compounds of the Formula I:
wherein R 1 and R 2 are as defined herein.
|
|
|
7326699 |
4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives
The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the...
|
|
|
7317006 |
Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
The invention relates to thieno[2,3-d]pyrimidine derivatives according to general formula I, or a pharmaceutically acceptable salt thereof,
wherein N(R1)R2 are joined in a...
|
|
|
7279474 |
Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF)
The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein the variables are as defined in the...
|
|
|
7273865 |
Thiazolopyridine
The present invention relates to compounds of formula I
wherein R 1 and R 2 are described hereinbelow. These compounds have high affinity to A 2A receptors and good selectivity to A 1 and A...
|
|
|
7273864 |
Compositions and methods for inducing osteogenesis
The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage, using compounds of the following formula: ...
|
|
|
7268133 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein
|
|
|
7268128 |
1,3,5-trisubstituted-5-phenyl and 5-pyridyl pyrazolopyrimidinone derivatives having PDE7 inhibiting action
Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB):
where the symbols are as disclosed in the specification, are provided as desired compounds. These...
|
|
|
7265111 |
Adenosine analogues and their use as pharmaceutical agents
The present invention relates to compounds according to the general formula (I)
wherein X is selected from the group consisting of
wherein n and p are independently 0, 1, 2, or 3, provided...
|
|
|
7262192 |
Substituted pyrazolo[4,3-d]pyrimidines and their use as PDE-5 inhibitors
The present invention comprises a class of 5,7-diaminopyrazolo[4,3-d]pyrimidine compounds. These compounds are useful as phosphodiesterase type 5 inhibitors. The present invention further comprises...
|
|
|
7262187 |
Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor
The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7262186 |
Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor
The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7259154 |
Pyrrolopyrimidines
Compounds of the formula
and N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisosteres of such salts or...
|
|
|
7253166 |
6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells
The invention provides a novel class of compounds and compositions of Formula I:
in which R 1 , R 2 and R 3 are defined herein, that are useful in the treatment or prevention of diseases...
|
|
|
7247610 |
Use of glutamate antagonists for the treatment of cancer
Disclosed are methods for treating cancer by administering an inhibitor of the interaction of glutamate with the KA receptor complex.
|
|
|
7244723 |
Substituted furopyrimidinones as a mitotic kinesin inhibitors
The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7235551 |
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
Novel substituted pyrimidol[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
|
|
|
7235538 |
Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV
The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I
wherein each n is one or two independently and R 1 , R 2 , R 3 , R...
|
|
|
7229990 |
Bicyclic heteroaromatic compounds
A bicyclic heteroaromatic compound according to general formula I, or a pharmaceutically acceptable salt thereof,
wherein
R 1 is (3–8C)cycloalkyl, (2–7C)heterocycloalkyl, (6–14C)aryl or...
|
|
|
7220758 |
Ether substituted imidazopyridines
Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the...
|
|
|
7217710 |
Substituted pyrazolopyrimidines
Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
|
|
|
7217702 |
Selective antagonists of A2A adenosine receptors
Selective antagonists of A 2A adenosine receptors like those of formula I are provided, wherein Y forms a ring.
The novel A 2A blockers are useful for the treatment of Parkinsons disease and...
|
|
|
7208489 |
2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones
The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent...
|
|
|
7192931 |
Treatment of demyelinating diseases
This invention relates to methods for the treatment or prevention of central nervous system (CNS) cell damage and functional damage in mammals due to demyelinating disease including multiple...
|
|
|
7189715 |
Compositions comprising zopiclone derivatives and methods of making and using the same
The invention is directed to racemic and stereomerically pure compounds of Formula 3:
and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
|
|
|
7186716 |
3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
Compounds of Formula I are useful as mediators of protein kinases and have activity as cell proliferation inhibitors:
where X, R 1 –R 7 and R 9 are as defined herein.
|
|
|
7183274 |
Piperidine-2,6-diones heterocyclically substituted in the 3-position
Piperidine-2,6-diones heterocyclically substituted in the 3-position corresponding to formula I
Also the production and use of such compounds in pharmaceutical formulations and related methods...
|
|
|
7166596 |
Heterocyclic aromatic compounds useful as growth hormone secretagogues
Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the general structure of formula I
...
|
|
|
7160899 |
Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
This invention relates to the use of the combined action of a compound with neurotrophic activity and an adenosine A 2A receptor antagonist for the treatment of Parkinson's disease.
|
|
|
7151101 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention relates to compounds...
|
|
|
7141568 |
Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions...
|
|
|
7138400 |
Sulfamides as gamma-secretase inhibitors
Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of...
|
|
|
7135470 |
Thienopyridazines as IKK inhibitors
The invention provides compounds of the formula I:
or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: A, Y, Z and R 1 are as defined herein. Also provided are...
|
|
|
7135469 |
Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
The present application describes linear chain substituted monocyclic and bicyclic compounds and derivatives thereof of Formula I:
P 4...
|
|
|
7129239 |
Purine compounds and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ...
|
|
|
7125890 |
Ether substituted imidazopyridines
Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the...
|
|
|
7098221 |
Amide substituted imidazopyridines
Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of...
|
|
|
7091198 |
2,5-disubstituted pyrimidine derivatives
The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for...
|