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7371749 |
Benzothiazole derivatives
The present invention relates to compounds of formulae IA and IB
wherein
R 1 and R 2 are each independently lower alkyl or —(CH 2 ) m —O-lower alkyl, or together with the N atom to which...
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7368446 |
4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
The present invention relates to the compound of formula
which is 4-hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide, and to pharmaceutically...
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7358244 |
Azabicycloalkane compounds
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
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7351729 |
JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective...
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7338949 |
Mycobacterial inhibitors
The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib)
salts, quaternary amines, stereochemically isomeric...
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7335667 |
Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as Janus kinase inhibitors
The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related...
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7304059 |
Substituted quinazolin-4-ylamine analogues
Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
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7304058 |
Carbamic acid esters of benzothiazoles
The present invention relates to a compound of formula I
wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the...
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7285548 |
Urea substituted benzothiazoles
The present invention relates to compounds of formula I
wherein
R 1 and R 2 are described herein, and their pharmaceutically acceptable salts thereof for the treatment of diseases,...
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7282499 |
Sigma receptor inhibitors
The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to...
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7273865 |
Thiazolopyridine
The present invention relates to compounds of formula I
wherein R 1 and R 2 are described hereinbelow. These compounds have high affinity to A 2A receptors and good selectivity to A 1 and A...
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7199119 |
Antiinflammation agents
Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In...
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7166595 |
Compounds, methods and compositions
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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7148233 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as hypertrophy are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7144892 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as myocardial infarction are described. The methods are directed to concurrently administering a compound such as...
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7132430 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as arrhythmia are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7125889 |
Treating of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as blood clots are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7119102 |
Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
Disclosed are compounds of formula (I):
wherein the variables R 1 , R 2 , R 3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK)...
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7115626 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as ischemia, ischemia reperfusion injuries, and myocardial ischemia, are described. The methods are directed to concurrently...
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7115625 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such congestive heart failure are described. The methods are directed to concurrently administering a compound such as...
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7105514 |
Substituted indolealkanoic acids
Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the...
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RE39265 |
Heteroarylpiperidines, and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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7091219 |
Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors
Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease...
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7091199 |
Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
The compounds are of the class of thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical conditions...
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7067515 |
Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease
The invention provides compounds of Formula I:
where in W is
These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The...
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7045528 |
Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
The invention relates to compounds represented by the formula I
and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and...
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7030139 |
Compounds
Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in...
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7019001 |
Substituted benzothiazole amide derivatives
A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A 2 receptor system comprising administering a compound of formula
to a person in need of...
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6995171 |
Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents
The invention relates to compounds of the formulas 1 and 2
and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, R 1 and R 11 ...
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6992083 |
Benzoxazol derivatives
The invention relates to compounds of formula
wherein
R is phenyl, unsubstituted or substituted by halogen or —CH 2 N(CH 3 )(CH 2 ) n OCH 3 , or
is benzyl, lower alkyl, lower...
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6964961 |
Thiophene derivatives useful as anticancer agents
The invention relates to compounds of the formula 1
or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R 1 , R 2 and R 11 are...
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6956036 |
6-hydroxy-indazole derivatives for treating glaucoma
Substituted 1-(α-alkyl-ethylamino)-1H-indazol-6-ols useful for lowering and controlling IOP and treating glaucoma are disclosed
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6924283 |
4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents
The invention provides a compound of formula I:
wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well...
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6900227 |
Benzodioxole derivatives
The present invention relates to compounds of the general formula
and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such...
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6878705 |
4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents
The invention provides a compound of formula I:
wherein G, R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
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6867230 |
Hygromycin A derivatives
This invention relates to compounds of the formula
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The...
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6831081 |
4-Oxo-4,7-dihydrothieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents
The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6787559 |
Sulfonamide compounds
This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for...
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6734179 |
Benzothiazoles
The present invention relates to compounds of the formula wherein R1 and R2 are as described within. The compounds of formula I have been found to be adenosine receptor ligands. Specifically,...
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6730671 |
Compounds useful as reversible inhibitors of cathespin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
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6730669 |
Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such...
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6703347 |
Isothiazole derivatives and their use as pesticides
A compound of formula (I), where A is optionally substituted alkylene, alkenylene, alkynylene, cycloalkylene, alkylenoxy, oxy(C 1-6 )alkylene, alkylenthio, thio(C 1-6 )alkylene, C 1-6 alkylenamino,...
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6696439 |
5-HT1F agonists
The present invention relates to substituted furo[3,2-b]pyridine compounds of formula I: or a pharmaceutical acid addition salt thereof; where; R is E—D is C═CH or CH—CH 2 ; R 1 is...
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6686357 |
FKBP inhibitors
Compounds of formula (I), their salts and solvates, wherein the substituents are as described herein, are FKBP inhibitors.
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6620811 |
Isonicotin- and nicotinamide derivatives of benzothiazoles
The present invention relates to compounds of the formula wherein R1, A and R are as described within. The compounds of the present invention have been found to be adenosine receptor ligands....
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6620810 |
4-thioxo-4,7-dihydro-thieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents
The invention provides a compound of formula I: wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
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6613772 |
Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments
Compounds of the formula I in which R 1 , R 2 , R 3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and...
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6608057 |
Compounds useful as reversible inhibitors of cathepsin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
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6599901 |
Pyridone substituted benzothiazole derivatives
The present invention relates to compounds of the formula wherein R is as defined herewithin. The compounds of formula I have a good affinity to the A 2A receptor and therefore they may be used...
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6596718 |
7-Morpholin-4yl-benzothiazole amide derivatives
A compound of the formula A compound of formula I has a good affinity to the A 2A receptor and is useful for the treatment of diseases mediated by this receptor.
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