|
Match
|
Document |
Document Title |
|
|
7354918 |
Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof
The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I)
in which R represents a radical —AR′ wherein A represents a heteroatom and R′...
|
|
|
7342012 |
Inhibitors of αLβ2 mediated cell adhesion
The present invention relates to a compound of the following formula:
or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of...
|
|
|
7314871 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension
The application claims a method for treating hypertension by administering an effective amount of a compound of the formula (I)
wherein the variable groups are as defined in the specification...
|
|
|
7279473 |
Pyrazolopyridazine derivatives
Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods...
|
|
|
7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
|
|
|
7247642 |
Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their...
|
|
|
7247626 |
Pyrazolopyrimidine derivatives and pharmaceutical compositions containing them
The present invention provides compounds of formula (I):
pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
|
|
|
7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
|
|
|
7196078 |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
|
|
|
7157451 |
Heterocyclic dihydropyrimidine compounds
Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors...
|
|
|
7153848 |
Inhibitors of HCV replication
Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions...
|
|
|
7141567 |
Polysubstituted imidazopyridines as gastric secretion inhibitors
The invention relates to imidazopyridines of a certain formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric...
|
|
|
7135480 |
Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
The present invention is directed to substituted 1-benzoyl-3-cyano-pyrrolo[1,2-α]quinolines and analogs thereof, represented by the general Formula I:
wherein R 1 –R 8 , L, Q, dash line and...
|
|
|
7122540 |
2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
|
|
|
7109195 |
Hexacyclic compounds and their therapeutic use
The present invention relates to hexacyclic compound of the formula [1],
wherein Z, R 3 and R 4 are as identified therein, and pharmaceutically acceptable salts thereof. These compounds are...
|
|
|
7056917 |
Drug efflux pump inhibitor
A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I):
wherein,...
|
|
|
7041675 |
Heterocyclic compounds and their use as PARP inhibitors
The invention relates to compounds of the formula I
and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.
|
|
|
7034016 |
8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives
8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives of formula (I):
or a pharmaceutically acceptable salt thereof processes for their preparation, pharmaceutical compositions...
|
|
|
7030112 |
Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
Disclosed are pyrrolopyridazine compounds of the formula,
wherein the substituents are defined herein,
methods of preparing such compounds, and their use for the treatment of proliferative,...
|
|
|
7022701 |
Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
|
|
|
7008957 |
Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments
The invention relates to compounds of the formula I
in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their...
|
|
|
6964960 |
Indoloquinazolinones
The invention provides compounds of formula (I) wherein R is as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals, for use in the...
|
|
|
6951867 |
N-substituted piperidinyl-imidazopyridine compounds as 5-HT4 receptor modulators
This invention provides a compound of the formula (I):
or a pharmaceutically acceptable salt, amide or ester thereof, wherein R 1 represents a hydrogen atom or a halogen atom; R 2 represents...
|
|
|
6933294 |
Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same
Compounds having the formula (I),
and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R 1 , R 2 , and R 3 are hydrogen,...
|
|
|
6916825 |
Alkylated imidazopyridine derivatives
Compounds of the formula 1
in which the substituents have the meanings mentioned in the description are suitable for the prevention and treatment of gastrointestinal diseases.
|
|
|
6911443 |
Imidazopyrimidine derivatives and triazolopyrimidine derivatives
A compound of the formula (I)
in which R 1 is —OR 11 , —SR 11 , —SOR 11 , —SO 2 R 11 , —NHR 11 , or —NR 12 R 13 , and R 11 , R 12 , and R 13 are as defined broadly in the text....
|
|
|
6908916 |
C-5 modified indazolylpyrrolotriazines
The present invention provides compounds of formula I
and pharmaceutically acceptable salts thereof.
The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such...
|
|
|
6900209 |
Nitrogen substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives for enhancing cognition
The present invention provides a compound of formula (I) wherein A is an optionally substituted C 1-4 alkylidene group or a bond, R 20 and R 21 are hydrogen, alkyl groups or heterocyclic groups,...
|
|
|
6897222 |
Pyrido[2,1-a]isoquinoline derivatives
The present invention provides compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification, and pharmaceutically acceptable salts thereof. The...
|
|
|
6890922 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
|
|
|
6869949 |
Polysubstituted imidazopyridines as gastric secretion inhibitors
The invention relates to imidazopyridines of a certain formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric...
|
|
|
6864259 |
Antibacterial agents
The present invention provides compounds of Formula (I):
wherein R 1 -R 6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
|
|
|
6852739 |
Methods using proton pump inhibitors and nitric oxide donors
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
|
|
|
6825194 |
Hexacyclic compounds
The present invention relates to hexacyclic compound of the formula [1], wherein Z, R 3 and R 4 are as identified therein, and pharmaceutically acceptable salts thereof. These compounds are...
|
|
|
6806268 |
Method for treating glaucoma V
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the...
|
|
|
6777410 |
Isoindole derivatives
This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R 1 and R 2 are the same or different and represent hydrogen atoms, etc.,...
|
|
|
6740650 |
Heterocyclic cytotoxic agents
The invention provides compounds of formula I: wherein R 1 -R 8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also...
|
|
|
6730671 |
Compounds useful as reversible inhibitors of cathespin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
|
|
|
6696461 |
Tricyclic imidazopyridines
Compounds of formula (I) in which the substituents as defined in the description are useful for preventing and treating gastrointestinal disorders.
|
|
|
6696441 |
Inhibition of p53-induced stress response
The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or...
|
|
|
6686356 |
Pyridoquinoxaline antivirals
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 are as defined in the specification. The compounds are useful for the...
|
|
|
6683081 |
Triazolotriazinones and the use thereof
The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
|
|
|
6670357 |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): ...
|
|
|
6642229 |
3-Phenyl-imidazo-pyrimidine derivatives as ligands for GABA receptors
A class of 3-phenylimidazo(1,2-a)pyrimidine derivatives (of Formula I, or salt or prodrug thereof: I) wherein Y represents a chemical bond, an oxygen atom, or a —NH— linkage; Z represents an...
|
|
|
6630467 |
Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy
Pyridone-fused azabicyclic compounds of the formula and their pharmaceutically acceptable salts and prodrugs, wherein R 1 , R 2 and R 3 are defined below, intermediates and methods for their...
|
|
|
6624162 |
Imidazopyridine compounds as 5-HT4 receptor modulators
This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein R 1 is hydrogen, halo or alkyl; R 2 and R 3 are independently hydrogen, alkyl,...
|
|
|
6624159 |
Heterocycle carboxamides as antiviral agents
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
|
|
|
6608078 |
Antibacterial chiral 8-(substituted piperidino)-benzo &lsqb i,j&rsqb quinolizines, processes, compositions and methods of treatment
The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to...
|
|
|
6608057 |
Compounds useful as reversible inhibitors of cathepsin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
|
|
|
6602868 |
Treatments for restless legs syndrome
The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).
|