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7381721 |
Substituted piperidine compounds
3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are...
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7375105 |
Pyridine substituted furan derivatives as Raf kinase inhibitors
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
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7371749 |
Benzothiazole derivatives
The present invention relates to compounds of formulae IA and IB
wherein
R 1 and R 2 are each independently lower alkyl or —(CH 2 ) m —O-lower alkyl, or together with the N atom to which...
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7371747 |
Cyanoalkylamino derivatives as protease inhibitors
The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical...
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7371746 |
1,2,4-Thiadiazole compounds and pests controlling composition containing the same
The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R 1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene...
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7365067 |
Indanol derivative
The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist:
(wherein,
R 1 , R 2 : optionally substituted...
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7351713 |
Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
Compounds of formula I
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5...
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7351702 |
Caspase inhibitors and uses thereof
This invention provides compounds of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; next to R 3 represents a single or double bond;...
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7335672 |
Vanilloid receptor ligands and their use in treatments
Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache,...
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7329656 |
Arylthiobenzylpiperidine derivatives
This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective...
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7320992 |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7317007 |
Benzothiazole derivatives with activity as adenosine receptor ligands
The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
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7312211 |
Pryanone compounds useful as reversible inhibitors of cysteine proteases
Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 2 , R 3 , R 4 , R 6 , R 8 and Y are defined herein. The compounds are useful for...
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7307077 |
Heterocyclic compound and antitumor agent containing the same as effective ingredient
The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as...
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7291633 |
6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands
Compounds of the formula I in which R 1 , R 2 , R 3 and R 4 are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the...
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7288538 |
Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
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7285548 |
Urea substituted benzothiazoles
The present invention relates to compounds of formula I
wherein
R 1 and R 2 are described herein, and their pharmaceutically acceptable salts thereof for the treatment of diseases,...
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7279491 |
Phenylpiperidines and phenylpyrrolidines
Substituted phenylpiperidines and phenylpyrrolidines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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7279475 |
Fluorinated di-aryl urea compounds
Disclosed are compounds of formula(I):
wherein R 1 , R 2 , W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are...
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7279472 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune...
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7271181 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7262199 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
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7253205 |
Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 represent a variety of substituents, ring A is a phenyl or pyridyl...
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7253188 |
Aminobenzamide derivative
This invention relates to a novel compound represented by the formula (I):
or a pharmaceutically acceptable salt thereof,
wherein R 1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p...
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7241760 |
Heteroaryl-substituted imidazole derivatives
The present invention relates to imidazole derivatives of the general formula
wherein R 1 , R 2 , R 3 and R 4 are described hereinbelow. These compounds can be used in the treatment or...
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7241759 |
Benzo[1,2,5]thiadiazole compounds
Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7238691 |
Piperidine derivatives and their use as modulators of chemokine (especially CCR3) activity
The invention provides a compound of formula (I): T is C(O) or S(O) 2 ; W is CH 2 , (CH 2 ) 2 , CH(CH 3 ), CH(CH 3 )O or cyclopropyl; X is O, CH 2 , C(O), S, S(O), S(O) 2 or NR 3 ; m is 0 or 1; R...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7214675 |
Urea substituted imidazoquinoline ethers
Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the...
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7211576 |
Diaminothiazoles
Novel diaminothiazoles of formula (I):
are discussed. These compounds selectively inhibit the activity of Cdk4 and are thus useful in the treatment or control of cancer, in particular, the...
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7205313 |
Excitatory amino acid receptor antagonists
The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative...
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7202242 |
Substituted 1 and 2-naphthol Mannich bases
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of...
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7179804 |
Tachykinin receptor antagonists
The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of...
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7179794 |
Multivalent macrolide antibiotics
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial...
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7166609 |
Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
Pyrimidine-4,6-dicarboxylic acid diamides of the formula I
are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for...
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7163939 |
Macrocyclic kinase inhibitors
Compounds having the formula
are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using...
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7153853 |
Heterocyclic compounds and antitumor drugs containing the same as the active ingredient
The present invention relates to heterocyclic compounds represented by the formula I
wherein X represents nitrogen atom or CH; R 1 represents halogen atom or hydroxyl; R 2 represents hydrogen...
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7148218 |
Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain substituted polyketides of formula I,
wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of...
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7125888 |
Tyrosine kinase inhibitors
The present invention relates to imidazopyridine compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of...
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7122543 |
Substituted benzoic acid derivatives having NF-κB inhibiting action
A substituted benzoic acid derivative which is represented by the following formula (I) and has an NF-κB inhibiting action (in the formula, R 3 , R 4 and R 5 each independently represents a...
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7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
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7115637 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7101896 |
Pharmaceutical compositions and methods for use
The present invention relates to aryl olefinic azacyclic compounds and aryl acetylenic azacyclic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. The...
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7101879 |
Treatments for neurotoxicity in Alzheimer's Disease
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds...
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7101878 |
Non-peptide GNRH agents, methods and intermediates for their preparation
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active...
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7094801 |
Chalcone derivatives and their use to treat diseases
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7074784 |
Medicaments against viral diseases
Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.
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7071189 |
Heterocyclic compound and antitumor agent containing the same as active ingredient
The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as...
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