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7390803 |
Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
The present invention is directed to compounds of the formula (I) (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 27 , R 28 , R 29 , R 30 , R 31 , X, m, n and the...
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7388007 |
Gamma-lactams as beta-secretase inhibitors
There is provided a series of novel substituted gamma-lactams of Formula (I)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 4 , R 5 and R 6 as defined...
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7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
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7371749 |
Benzothiazole derivatives
The present invention relates to compounds of formulae IA and IB
wherein
R 1 and R 2 are each independently lower alkyl or —(CH 2 ) m —O-lower alkyl, or together with the N atom to which...
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7371746 |
1,2,4-Thiadiazole compounds and pests controlling composition containing the same
The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R 1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene...
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7365066 |
Pyrazolopyridine derivatives as pharmaceutical agents
Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of...
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7358247 |
Mycophenolate mofetil impurity
Provided is an impurity of mycophenolate mofetil, processes for its preparation and its use as a reference.
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7354920 |
Aryl and heteroaryl morpholine derivatives
Compounds of formula (I)
wherein Rx is H; Ry is H or C 1 -C 4 alkyl; each Rz is independently H or C 1 -C 4 alkyl; X represents O; Y represents OH or OR; R is C 1 -C 4 alkyl; and Ar 1 ...
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7329655 |
Nitrogenous heterocyclic compounds
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which...
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7323466 |
Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity
The present invention refers to chemical compounds of formula (I)
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1 ....
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7317010 |
Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R 1 , R 2 , R 4 , R 5 , R 6 , R 6a , R 7 , R 8 , A and B are as defined in the specification, which are...
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7304058 |
Carbamic acid esters of benzothiazoles
The present invention relates to a compound of formula I
wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the...
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7300930 |
Therapeutic acridone and acridine compounds
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond...
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7285568 |
Biaromatic compounds which activate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7285548 |
Urea substituted benzothiazoles
The present invention relates to compounds of formula I
wherein
R 1 and R 2 are described herein, and their pharmaceutically acceptable salts thereof for the treatment of diseases,...
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7279477 |
Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating...
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7279476 |
Pyrazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where B, R 1 , n, R 3 , Q, and R 4 are described in the specification. The compounds are useful...
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7279475 |
Fluorinated di-aryl urea compounds
Disclosed are compounds of formula(I):
wherein R 1 , R 2 , W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are...
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7273856 |
Linear basic compounds having NK-2 antagonist activity and formulations thereof
Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of...
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7273865 |
Thiazolopyridine
The present invention relates to compounds of formula I
wherein R 1 and R 2 are described hereinbelow. These compounds have high affinity to A 2A receptors and good selectivity to A 1 and A...
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7262215 |
N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors
This invention relates to N-carbacycle monosubstituted indolocarbazole compounds. Furthermore, this invention relates to medicaments comprising N-carbacycle monosubstituted indolocarbazoles...
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7256188 |
3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists
The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use...
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7247627 |
Salts and polymorphs of a pyrrole-substituted indolinone compound
The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl
]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-
pyrrole-3-carboxamide,...
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7241760 |
Heteroaryl-substituted imidazole derivatives
The present invention relates to imidazole derivatives of the general formula
wherein R 1 , R 2 , R 3 and R 4 are described hereinbelow. These compounds can be used in the treatment or...
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7235552 |
Cholenic acid amides and pharmaceutical compositions thereof
Novel sterol derivatives of formula (I), in which: R 1 represents a hydroxyl group or protected hydroxyl group, R 2 represents a hydrogen atom and a double bond is present at c, or R 1 and R 2 ...
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7232817 |
α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7223755 |
Hydroxymorpholinone derivative and medicinal use thereof
A compound represented by the following formula (I)
wherein R 1 and R 2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7202242 |
Substituted 1 and 2-naphthol Mannich bases
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of...
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7192980 |
Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain substituted polyketides of formula I,
wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and...
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7189715 |
Compositions comprising zopiclone derivatives and methods of making and using the same
The invention is directed to racemic and stereomerically pure compounds of Formula 3:
and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
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7183277 |
Carboxylic acid amides
Novel compounds of the formula I
in which
D, W, X, Y, T and R 1 are as defined in Patent Claim 1,
are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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7179794 |
Multivalent macrolide antibiotics
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial...
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7166593 |
Glucocorticoid receptor modulators
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor....
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7160874 |
Phenylalanine derivatives
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
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7132420 |
Aspartic protease inhibitors
The present invention provides an aspartic proteinase-inhibiting compound of the formula:
wherein a, b, c, d, and e, can be the same or different and each are R 7 , OR 7 , SR 7 , NR 7 R 8 ,...
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7129240 |
1,3-dihydro-2H-indol-2one derivatives, process for preparing them and pharmaceutical compositions containing them
The invention relates to compounds of formula:
as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and...
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7119085 |
Methods to treat alzheimer's disease
The present invention is directed toward substituted hydroxyethylene compounds of formula (XII)
useful in treating Alzheimer's disease and other similar diseases.
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RE39300 |
Inhibiting the development of tolerance to and/or dependence on an addictive substance
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor...
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7101877 |
Ion channel modulating compounds and uses thereof
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and...
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7087599 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7071212 |
N-(4-carbamimidoyl-phenyl)-glycine derivatives
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula:
wherein R 1 , E, X 1 to X 4 and G 1 and G 2 are as defined in the description and the...
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7030111 |
Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically,...
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7026315 |
Fungicide mixtures which are based on derivatives of morpholine or piperidine and derivatives oxime ether
Fungicidal mixtures, comprising as active components
a) a morpholine or piperidine derivative I selected from the group of the compounds Ia, Ib, Ic and Id
and
b) compounds of the formula II ...
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7022703 |
Acetylenic compound useful in treating inflammatory disorders
This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated...
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7019001 |
Substituted benzothiazole amide derivatives
A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A 2 receptor system comprising administering a compound of formula
to a person in need of...
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6998400 |
Pharmaceutically active morpholinol
Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and...
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6995183 |
Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
Compounds are provided having the formula (I)
wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be...
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6979685 |
Cycloalkyl amine compounds and uses thereof
Aminocycloalkyl compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo...
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