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7388006 |
Non-steroidal progesting
The present invention relates to non-steroidal progestins of the general formula (I)
wherein
R 1 and R 2 are independently of each other —H or —F, R 3 is —CH 3 or —CF 3 , and Ar is...
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7384937 |
Fused heterocyclic compounds and use thereof
Fused heterocylic compounds of the following Formula
wherein R 1 , R 2 , R 5 , Z, J 1 and J 2 are described herein, and analogs thereof are provided which are useful in treating leukocyte...
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7378416 |
MIF-inhibitors
3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C 3-8 )cycloalkyl, (C 1-4 )alkyl(C 3-8 )cycloalkyl, (C 6-18 )aryl or (C 6-18...
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7378415 |
Benzoxazine and quinoxaline derivatives and uses thereof
Compounds of the formula I:
or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein k, m, n, p, q, X, Y, Z, Ar, R 1 , R 2 , R 3 and R 4 are as defined herein. Also provided...
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7375104 |
Long acting beta-2-agonists and their use as medicaments
A compound of formula 1′
wherein:
V is —CH 2 —, —NH—, or —O—; R a and R b are each independently hydrogen, C 1-4 -alkyl, or halogen-C 1-4 -alkyl, or R a and R b together are...
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7375103 |
Optically active pyridine derivative and a medicament containing the same
An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-p
iperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an...
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7368445 |
Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms
The disclosed invention is directed to compounds of the formula: Formula (I) and methods of using these compounds.
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7365065 |
Non-peptide GnRH antagonists
Compounds according to general formula 1, wherein A 1 -A 3 are selected from A 5 and A 6 where A 5 is either ═CR 13 — or ═N— and A 6 is —NR 14 —, —O— or —S—; A 4 is either...
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7365064 |
Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their...
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7354917 |
Oxabispidine compounds and their use in the treatment of cardiac arrhythmias
There is provided compounds of formula I, wherein R 1 , R 2 , R 4 , R 41 to R 46 , A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of...
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7351706 |
Indol-3-yl-carbonyl-spiro-piperidine derivatives
This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I:
wherein the spiropiperidine-head group A...
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7351705 |
Carboxylic acid compounds and a pharmaceutical agent comprising the compound as the active ingredient
A carboxylic acid compound represented by formula (I):
(meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound.
Since...
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7348322 |
Glucocorticoid receptor modulators as antiinflammatory agents
The present invention relates to compounds of formula I:
wherein A, X, R 1 , R 2 and R 3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to...
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7326704 |
Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests
This invention pertains to methods for controlling invertebrate pests comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I ...
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7320985 |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
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7314883 |
Anti-migraine treatments
The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammaton, migraine and other headaches, thermal injury, circulatory shock, flushing associated with...
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7312214 |
1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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7312211 |
Pryanone compounds useful as reversible inhibitors of cysteine proteases
Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 2 , R 3 , R 4 , R 6 , R 8 and Y are defined herein. The compounds are useful for...
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7312209 |
Acridone inhibitors of IMPDH enzyme
Compounds having the formula (I),
wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2...
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7307076 |
Beta agonists for the treatment of respiratory diseases
The present invention relates to compounds of general formula 1
wherein the groups n, A, B, R 1 , R 2 and R 3 may have the meanings given in the claims and in the specification, processes for...
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7294650 |
Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders
Compounds of formula (I):
and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β 2...
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7265108 |
Nitrogen containing heterocyclic compounds and medicines containing the same
Compounds represented by the following general formula:
[wherein X 1 , X 2 , X 3 and X 4 each independently represent a single bond, C 1-6 alkylene, etc.; A 2 represents optionally...
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7244728 |
Long acting betamimetics for the treatment of respiratory diseases
The present invention relates to the compounds of general formula 1
wherein the groups R, R1, R2, R3 and A may have the meanings given in the claims and specification, processes for preparing...
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7244727 |
Fused bicyclic nitrogen-containing heterocycles
Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the...
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7244726 |
Heterocyclic compounds possessing affinity at 5HT1 -type receptors and use thereof in therapy
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:
wherein A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl,...
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7235550 |
Polycyclic azaindole compounds
The invention relates to compounds of formula (I):
wherein:
G 1 represents an alkylene chain as defined in the description, A represents
R 2 and R 3 represent...
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7217708 |
3,7-Diazabicyclo [3.3.1] formulations as anti-arrhythmic compounds
There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl) -9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-ni
trile; tert-butyl 2...
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7214674 |
Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:
wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl,...
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7205296 |
Substituted 2H-1,3-benzoxazin-4(3H)-ones
Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.
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7205295 |
Benzoxazin-3-ones and derivatives thereof as therapeutic agents
The present invention provides compounds of Formula I
wherein W, Q, E, D, R 6 , R 7 , R 8 , Y, K, R 9 , R 10 , R 12 , G, and the double bond denoted “*” have any of the values defined...
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7202241 |
Benzoxazine derivatives and uses thereof
Compounds of the formula (I):
or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, Y and m are as defined herein....
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7196108 |
Bicyclic heterocycles for the treatment of diabetes and other diseases
The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2...
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7196081 |
Compounds with hydroxycarbonyl-halogenoalkyl side chains
The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral...
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7189713 |
Piperidine derivatives
The present invention relates to piperidine derivatives of formula (I):
R represents halogen or C 1-4 alkyl R 1 represents C 1-4 alkyl; R 2 or R 3 independently represent hydrogen or...
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7186730 |
Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
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7176196 |
Bicyclic heterocycles as HIV integrase inhibitors
The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds...
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7169776 |
Method of preparing alkylated salicylamides via a dicarboxylate intermediate
The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention...
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7166592 |
Nonsteroidal antiinflammatory agents
Compounds of Formula 1
are useful in the treatment of inflammation.
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7166591 |
Catalytic cleavage of phosphate ester bonds by boron chelates
Novel chemical compounds are disclosed having the general formula L{YX m } n , wherein X is selected from the Group 13 elements, Y is a halide, and L is a chelating ligand containing at least one...
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7160888 |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
This invention relates to compounds of the formula 1
wherein G, D, A, Z, Q, X, Y, R 1 , and R 4 through R 7 are defined as in the specification, processes for preparing the same and...
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7160882 |
Long acting β-2-agonists and their use as medicaments
The present invention relates to compounds of formula 1
wherein the groups X, R a , R b , R 1 , R 1′ , R 2 , R 2′ , R 2″ , R 2′″ , V and n may have the meanings given in the claims...
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7160874 |
Phenylalanine derivatives
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
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7153852 |
Indole compounds, process for producing the same and drugs containing the same as the active ingredient
Indole derivatives represented by formula (I)
wherein all symbols represent the same as that in specification), production methods thereof, and DP receptor antagonist comprising them as active...
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7148217 |
Iminobenzoxazines, iminobenzthiazines and iminoquinazolines for controlling invertebrate pests
This invention pertains to methods for controlling invertebrate pests comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula...
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7141566 |
Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments.
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7141564 |
Nitrogen-containing bicyclic heterocycles for use as antibacterials
Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
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7141562 |
Substituted benzoxazinones and uses thereof
Compound of the Formula:
and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO 2 — or —(CR a R b ) r —, n is 1 or 2, R 2 is aryl or...
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7138395 |
Interleukin-1β converting enzyme inhibitors
The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula:
X is —CH 2 —, —O— or —NR 9 —; R is a...
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7129238 |
Mandelic acid derivatives
The invention is concerned with novel mandelic acid derivatives of formula (I)
wherein R 1 to R 10 , X and Y are as defined in the description and in the claims, as well as pharmaceutically...
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7122542 |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms...
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