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7358245 |
Treatment of gastroesophageal reflux disease
The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed.
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7326703 |
(1,10B-Dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
The present invention realtes to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well...
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7235550 |
Polycyclic azaindole compounds
The invention relates to compounds of formula (I):
wherein:
G 1 represents an alkylene chain as defined in the description, A represents
R 2 and R 3 represent...
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7208490 |
Tricyclic tetrahydroquinoline antibacterial agents
The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and...
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7179805 |
7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
The present invention relates to compounds having a structure according to Formula I
wherein n, m, z, R, R 2 , R 3 , R 4 , R 5 , R 6 , A, E, X, Y, a and b are as defined above;
or an optical...
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7160899 |
Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
This invention relates to the use of the combined action of a compound with neurotrophic activity and an adenosine A 2A receptor antagonist for the treatment of Parkinson's disease.
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7153851 |
10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium
A compound as represented by the general formula (I) shown below exhibits high antibacterial activity against gram-positive bacteria, in particular, such drug-resistant bacteria as mRNA, PRSP and...
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6919334 |
Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine
Compounds of the formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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6887868 |
Therapeutic 5-HT ligand compounds
The present invention provides compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 R 7 , R 8 , n, m, and X have any of the values defined in the specification, as well as...
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6821969 |
Thioxazinoquinolones as antiviral agents
The present invention provides a compound of formula I These compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6794391 |
Derivatives of pyrimido&lsqb 6.1-a&rsqb isoquinolin-4-one
The invention provides compounds or salts thereof of the general formula (I): wherein each of R 1 and R 2 independently represents a C 1-6 alkyl or C 2-7 acyl group; X represents OCH 2 or a...
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6756368 |
Use of cobalt chelates for treating or preventing virus infection
A method of treating a subject infected with a virus or a method of preventing viral infection of a subject comprising administering to the subject an effective amount of a compound having the...
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6716830 |
Ophthalmic antibiotic compositions containing moxifloxacin
Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The...
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6713468 |
Methods of using thiazolobenzoheterocycles
Methods of using compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof.
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6673793 |
Oxazinoquinolones useful for the treatment of viral infections
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6624159 |
Heterocycle carboxamides as antiviral agents
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6620808 |
Endocrine modulation with positive modulators of AMPA type glutamate receptors
Methods for modulating the endocrine system of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA receptors of the hypothalamus are administered to the host. The...
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6608048 |
Tricyclic protein kinase inhibitors
This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the...
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6602868 |
Treatments for restless legs syndrome
The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).
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6573260 |
Cycloalkyl-substituted aminomethylpyrrolidine derivatives
This invention provides a quinolone derivative which exerts strong antibacterial action upon various bacteria and has high safety, and it relates to a compound having a structure of formula (I),...
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6552018 |
Pyrazole derivatives
The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a...
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6448241 |
Thiazolobenzoheterocycles, their preparation and medicaments containing them
Compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them...
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6432948 |
USE OF 7-(2-OXA-5,8-DIAZABICYLCO&lsqb 4.3.0&rsqb NON-8-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDON CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF HELIOBACTER PYLORI INFECTIONS AND ASSOCIATED GASTRODUODENAL DISEASES
The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives, which are substituted in the 7-position by a 2-oxa-5,8-diazabicyclo[4.3.0]-non-8-yl) radical, and their...
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6376488 |
Benzoxazine α-1 adrenergic compounds
The present invention relates to compounds having formula I and to pharmaceutically acceptable salts thereof. Compounds of formula I inhibit α 1 adrenoreceptors and may be useful for treating...
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6331540 |
Pharmaceutical compositions containing a fluoroquinolone antibiotic drug and xanthan gum
Pharmaceutical compositions containing a fluoroquinolone antibiotic drug, xanthan gum and a water-soluble calcium salt in an amount sufficient to make the fluoroquinolone antibiotic drug and...
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6288081 |
Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith
The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl radical, and of...
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6191129 |
Bicyclic amine derivative
A pyridobenzoxazine derivative having a bicyclic amine derivative as its substituent, represented by the formula (I): ##STR1## exhibiting antimcrobial activity, and useful in treating infectious...
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6187786 |
Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
This invention concerns compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an...
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6114329 |
5-HT.sub.4 receptor antagonists useful in the treatment of gastroinstestinal, cardiovascular and CNS disorders
Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--CH 2 --Z ...
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6057317 |
Heterocyclic compounds
Compound of formula (I): ##STR1## wherein: Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and n are as defined in the description, and medicinal products containing the same which are useful as...
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6030968 |
Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
Methods for increasing the level of neurotrophic factors and neurotrophic factor receptors in the brain of a mammal afflicted with a pathology which produces neurodegeneration without significant...
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6017912 |
Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle
A method of treating bacterial infections of the skin comprising topically administering a pharmaceutical composition comprising fluoroquinolones selected from the group consisting of...
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6017911 |
Pyridonecarboxylic acid derivatives and intermediates for the synthesis thereof
This invention relates to pyridonecarboxylic acid derivatives of the following general formula, esters thereof and salts thereof, as well as pharmaceutical preparations containing them. ##STR1##...
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5990122 |
Quinolone- and naphthyridonecarboxylic acid derivatives
The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their...
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5985871 |
Benzoxazine compounds for enhancing synaptic response
Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for...
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5962447 |
Benzoxazines for enhancing synaptic response
Compounds based on the benzoxazine ring system are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering...
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5935952 |
Quinolone- or naphthylidone-carboxylic acid derivates or their salts
This invention relates to a novel quinolone- or naphthyridone-carboxylic acid derivative or its salt useful as an antibacterial agent, said derivative has a substituent represented by the following...
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5854241 |
Pyrido 3,2,1-I,J! 3,1!benzoxazine derivatives
Disclosed are pyrido 3,2,1-i,j! 3,1!benzoxazine compounds of the formula (I): ##STR1## wherein z represents a radical having the formula: ##STR2## wherein B represents --CH 2 --, --O-- or a direct...
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5783574 |
Imidazolylakyl derivatives of imidazo 5,1-c! 1,4!benzoxazin-1-one process for their preparation
Novel 5-HT 3 receptor antagonist compounds having following formula (I) ##STR1## wherein n is 1, 2 or 3; each of R, R 1 and R 2 , which may be the same or different, is hydrogen, halogen,...
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5770597 |
Quinolone derivatives and processes for preparing the same
The present invention relates to quinoline derivatives substituted in the 7-position by a trans-2,8-diazabicyclo 4.3.0!nonan-8-yl group having a broad antibacterial spectrum and to processes for...
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5756506 |
Single high dose fluoroquinolone treatment
The present invention relates to treatment of bacterial infections in animals with fluoroquinolones. More specifically, the present invention relates to the use of fluoroqunolones in a single high...
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5739130 |
Heterotricyclic derivatives, process for their preparation and pharmaceutical compositions containing them
Heterotricyclic derivatives of the formula: ##STR1## wherein R 1 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, amino or protected amino, R 2 is hydroxy, protected...
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5707988 |
Benzo d! isoxazole derivatives, compositions containing them and their use in therapy
Compounds of formula (I) ##STR1## in which X represents a group >O, >S, >CO or >NR wherein R is hydrogen, C 1 -6 alkyl, phenyl or C 7 -12 phenalkyl, R 1 and R 2 each represent...
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5688791 |
Aryl group-or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-hiv agent
Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the...
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5686095 |
Method of treating canker sores
A method of treating canker sores is disclosed by which a fluoroquinolone is topically applied to the ulcerous area. The fluoroquinolone is shown to be applied in solution form, and also as a...
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5672600 |
Antimicrobial dithiocarbamoyl quinolones
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 3 , R 4 , and R 6 form any of a variety of quinolone and related...
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5672599 |
Compounds containing a fused bicycle ring
Compounds of the formula ##STR1## wherein X is O or S--(O) t ; n is one; m is zero or one; Y is CH 2 , O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is ##STR2## are...
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5622950 |
Pyrrolo-pyridine derivatives
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a...
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5610158 |
4-oxo- and 4H-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents
Imidazo-benzoxazines of Formula (I) and pharmaceutically acceptable salts thereof. ##STR1## where Q is selected from (A) through (H) ##STR2## or pharmaceutically acceptable salts thereof wherein...
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5589476 |
Imidazol-4-ylpiperidine derivatives, their preparation and their application in therapeutics
A compound of formula (I): ##STR1## in which R 1 represents a hydrogen atom or a straight or branched (C 1 -C 4 )alkyl group; and A represents a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl...
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