Matches 51 - 100 out of 121 < 1 2 3 >
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5707988 Benzo d! isoxazole derivatives, compositions containing them and their use in therapy  
Compounds of formula (I) ##STR1## in which X represents a group >O, >S, >CO or >NR wherein R is hydrogen, C 1 -6 alkyl, phenyl or C 7 -12 phenalkyl, R 1 and R 2 each represent...
5688791 Aryl group-or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-hiv agent  
Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the...
5686095 Method of treating canker sores  
A method of treating canker sores is disclosed by which a fluoroquinolone is topically applied to the ulcerous area. The fluoroquinolone is shown to be applied in solution form, and also as a...
5672599 Compounds containing a fused bicycle ring  
Compounds of the formula ##STR1## wherein X is O or S--(O) t ; n is one; m is zero or one; Y is CH 2 , O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is ##STR2## are...
5672600 Antimicrobial dithiocarbamoyl quinolones  
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 3 , R 4 , and R 6 form any of a variety of quinolone and related...
5622950 Pyrrolo-pyridine derivatives  
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a...
5610158 4-oxo- and 4H-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents  
Imidazo-benzoxazines of Formula (I) and pharmaceutically acceptable salts thereof. ##STR1## where Q is selected from (A) through (H) ##STR2## or pharmaceutically acceptable salts thereof wherein...
5589476 Imidazol-4-ylpiperidine derivatives, their preparation and their application in therapeutics  
A compound of formula (I): ##STR1## in which R 1 represents a hydrogen atom or a straight or branched (C 1 -C 4 )alkyl group; and A represents a 5,6-dihydro-4H-imidazo[4,5,1-ij]quinol-2-yl...
5512566 Tricyclic compounds having affinity for the 5-HT1A receptor  
Compounds represented by the general formula I: ##STR1## are disclosed as useful in treating diseases of the central nervous system.
5494909 Substituted oxazinoisoquinoline derivatives, pharmaceutical compositions containing them and process for preparing same  
New compounds with the ability to inhibit calcium uptake in the brains of mammals are disclosed of the Formula (I) ##STR1## wherein R 1 is hydrogen, C 1 to C 4 alkyl, phenyl, or phenyl-C 1 to C...
5474988 5-phenylpyrrolo-1,4-benzoxazine and 5-phenylpyrrolo-1,4-benzothiazine compounds, process and intermediates for their production and pharmaceutical compositions containing them  
Pharmacologically active compounds of formula I ##STR1## which can be substituted in the phenyl rings and in which R 1 denotes hydrogen or lower alkyl, R 2 denotes hydrogen or lower alkyl, ...
5462938 Arthropodicidal oxadiazinyl, thiadiazinyl and triazinyl carboxanilides  
Arthropodicidal carboxanilides of Formula I and II ##STR1## wherein Q is selected from the group ##STR2## A, E, G, X, X 1 , Y, Z, Z 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in the...
5436240 Heterocyclic amines having central nervous system activity  
Tricyclic nitrogen containing compounds, having central nervous system activity of the following structural formula: ##STR1## and pharmaceutically acceptable salts thereof wherein R 1 , R 2 , and R...
5416096 7-(1-pyrrolidinyl)-3-quinolone carboxylic acid derivatives as antibacterial agents and feed additives  
7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X 1 is halogen, X 2 is hydrogen,...
5409924 Benzo-fused oxazobicyclo terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension  
Compounds characterized generally as benzo-fused oxazobicyclo-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension....
5401741 Topical preparation for treating otopathy  
A topical preparation for treating otophathy which contains ofloxacin or a salt thereof as an active ingredient is disclosed.
5380718 Arthropodicidal fused tetrahydropyridazines  
Arthropodicidal tetrahydropyridazines of Formulae I and II, ##STR1## wherein Q,X,X 1 Y, and G are as defined in the text, compositions containing them and their use in the control of arthropods.
5364854 Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation  
Derivatives of 2,3,3a,4-tetrahydro-2-azabicyclo alkyl-1H-imidazo[5,1,-c][1,4]benzoxazin-1-one are provided of general formula (I) ##STR1## in which inter alia R 3 represents ##STR2## wherein n is...
5308843 Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids  
A method of inhibiting mammalian topoisomerase II and inhibiting the growth and inducing the regression of malignant cells in mammals by the action of a...
5276039 Substituted indazole arthropodicides  
Indazole arthropodicides, compositions containing them and a method for controlling arthropods employing these indazoles as the active ingredient. The indazoles have the following general formula...
5175160 Antimicrobial agent for animals  
An antimicrobial agent for animals is disclosed. The agent comprises as an effective component a racemate of a 3S-type compound of a pyrido[1,2,3-de][1,4]benzoxazine derivative represented by the...
5164400 Pyrroloquinoline compounds  
The invention relates to a compound of the formula: ##STR1## in which R 1 and R 2 are each hydrogen or lower alkyl, R 3 is aryl or unsaturated, 5- or 6-membered heterocyclic group containing...
5153203 Quinolone derivatives and salts thereof, preparation processes thereof, and antibacterial agents containing the same  
Antibacterial quinolone derivatives represented by the following formula and salts thereof are disclosed. ##STR1## wherein R 1 meawns a substituted or unsubstituted lower alkyl group, a...
5147873 Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters  
Compounds of the formula ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, or a pharmaceutically acceptable cation; Y is cyclopropyl, ethyl or p-fluorophenyl, and X is hydrogen or fluoro, or...
5112820 Anti-glaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-(1,2,3-de)-1,4-benzoxazines and method of use thereof  
Antiglaucoma compositions containing 2- and 3-aminomethyl-6-arylcarbonyl- or 6-phenylthio-2,3-dihydropyrrolo-[1,2,3-de]-1,4-benzoxazines as the active component thereof and the method of use...
5104868 Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters  
This invention relates to novel tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and certain esters and cation salts thereof. The compounds of this...
5059597 7-(4-oxa or 4-thia-2,7-diazabicyclo[3.3.0]oct-2-en-3-yl)-3-quinolone-and-naphthyrido ne-carboxylic acid derivatives as antibacterial agents and feed additives  
7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X 1 is halogen, X 2 is hydrogen,...
5053407 Optically active pyridobenzoxazine derivatives and anti-microbial use  
An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The...
5023257 Intramuscular injection forms of gyrase inhibitors  
Ciprofloxacin and related gyrase inhibitors are tolerated well if administered intramuscularly in the form of an aqueous suspension of the betaine form having an approximate neutral pH value or in...
5001129 Oxazoloquinoline compounds and therapeutic application thereof  
The present invention relates to tricyclic carbamates coplying with the formula ##STR1## in which n=0, 1 or 2, p=0 or 1, R 1 represents a hydrogen atom; a group which is alkyl in C 1 -C 4 ...
4990508 Pyridone carboxylic acid derivatives and salts thereof, process for producing the same and antibacterial agents comprising the same  
This invention relates to a novel pyridone carboxylic acid derivative having a substituted or unsubstituted cyclopropyl group at the 10-position of pyridobenzoxazine, pyridobenzothiazine or...
4990517 7-(1-pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives  
7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X 1 is halogen, X 2 is hydrogen,...
4988709 Quinolone-carboxylic acids as antibacterial agents  
Novel pyridonecarboxylic acids of the formula: ##STR1## or the pharmaceutically acceptable salts thereof having a more potent and longer lasting antibacterial activities against gram-positive and...
4980287 4H-3,1-benzoxazin-4-one compounds and pharmaceutical compositions thereof for the inhibition of serine proteases  
A 4H-3,1-benzoxazin-4-one compound of the formula (I): ##STR1## wherein R is a hydrogen atom or alkyl radical, A is an amino acid residue or a peptide having 2 to 3 amino acid residues, which amino...
4980358 Method employing gonadal hormones and dopamine agonist intended for combined use in the improvement of lymphocyte function  
A new method, useful as a pharmacologic strategy, contains a gonadal hormone in combination with a dopamine agonist such as bromocriptine, and optionally an ascorbate source. This method has a...
4978661 Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis  
The present invention relates to the use of 6-halo-4-quinolone derivatives and pharmaceutical compositions comprising them as active ingredient, for the preparation of a medicament for the...
4973590 Process for the preparation of quinolonecarboxylic acids which can be administered parenterally  
Known quinolone carboxylic acid derivatives of the formula ##STR1## are treated so as to become readily administrable parenterally, the treatment comprising dissolving the active compound using an...
4965262 Method for treating or preventing locally periodontal disease  
A method for treating or preventing periodontal disease which comprises administering ofloxacin or salts thereof locally to periodontal tissue are disclosed. The method is excellent on the...
4923862 Topical preparation containing ofloxacin  
A topical preparation containing, as an active ingredient, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihy dro-7H-pyrido[ 1,2,3][1,4]-benzoxazine-6-carboxylic acid or a salt thereof.
4839355 Tricyclic-pyridinylquinoline compounds, their preparation and use  
Fluorinated 10-(2,6-dimethyl-4-pyridinyl)-3-methyl-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-d e][1,4]benzoxazine-6-carboxylic acids and -benzothiazine-6-carboxylic acids of the formula ##STR1## wherein R...
4822801 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents  
Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial...
4816451 Antibacterial 1,8-bridged 4-quinolonecarboxylic acids  
Antibacterially effective 1,8-bridged 4-quinolone-3-carboxylic acids and derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR 7 or an...
4808585 Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids  
The invention relates to solutions of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids, and in particular both ready-to-use injection and/or infusion solutions and dosage forms...
4762831 Antibacterial 1,8-bridged 4-quinolone-3-carboxylic acids  
A process for the preparation of a 1,8-bridged 4-quinolone-3-carboxylic acid of the formula ##STR1## wherein the substituents are defined hereinbelow. Some of the compound are new. The old and new...
4753953 Pyridonecarboxylic acid derivatives and antibacterial pharmaceutical compositions thereof  
Pyridonecarboxylic acid derivatives of the following formula, ##STR1## wherein R is hydrogen atom or lower alkyl group, R 1 is lower alkyl group, cycloalkyl group or haloalkyl group, Y is hydrogen...
4735940 Tricyclic pyridine derivatives and pharmaceutical compositions  
Compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt of a compound of formula I which has one or more basic substituents, are described. The compounds of formula I...
4729998 Cyclic carbamates and fungicidal use  
Fungicidally active cyclic carbamates of the formula ##STR1## in which X and Y each represent oxygen or sulfur, Z represents hydrogen, halogen, alkyl or nitro, and n is 2 or 3. Some...
4623647 [1,3]oxazino[4,3-a]-isoquinoline derivatives and pharmaceutical compositions containing them  
The invention relates to new [1,3]oxazino[4,3-a]-isoquinoline derivatives of the formula (I) ##STR1## wherein R 1 and R 2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R 3 is...
4623650 Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids  
1-Substituted-6-fluoro-7-aryl-(8-fluoro)-1,4-dihydroquinol-4 -one 3-carboxylic acids having antibacterial activity are prepared by reacting the corresponding alkyl...
4605653 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or -thiazino-[4,3-a]isoquinoline derivatives and pharmaceutical compositions containing them  
The invention relates to 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or -thiazino-[4,3-a]isoquinoline derivatives of the formula (I), ##STR1## wherein R 1 and R 2 are alkoxy having...
Matches 51 - 100 out of 121 < 1 2 3 >