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8178500 |
Pesticidal compositions
Stabilized mixtures of pesticides are disclosed.
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8178512 |
Methods and compositions for treating diseases and disorders associated with siglec-8.
The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the...
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8173608 |
Compound having cyclic structure and use thereof
The present invention relates to a compound represented by the following formula (1′) wherein R is an aldopyranose residue, R2 is a C2-18 hydrocarbon group optionally having substituent(s), R3 is a...
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8173798 |
Vaccine
The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the...
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8163704 |
Glycoside derivatives and uses thereof
This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium...
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8163303 |
Nutritional composition for the treatment of pressure ulcers
The invention pertains to a method of treating or preventing pressure ulcers, comprising enterally administering to a subject in need thereof a composition comprising proteins, carbohydrates, fats,...
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8163703 |
Hepatitis C therapies
The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections.
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8153600 |
Direct application of non-toxic crosslinking reagents to resist progressive spinal deformity
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous...
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8148321 |
Bioconjugates as therapeutic agent and synthesis thereof
The present disclosure relates to a novel enzymatic approach according to the invention using an unprecedented sortase-catalyzed transpeptidation reaction between a substrate comprising LPXTG (SEQ...
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8143226 |
Tyrosine kinase receptor antagonists and methods of treatment for breast cancer
A method of treatment is disclosed whereby cancer cells are brought into contact with a formulation comprising an inhibitor of tyrosine kinase receptors. The formulation may be comprised of an...
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8138157 |
Antibiotic formulation and method of treatment
A formulation comprised of particles which may be in groups and are comprised of a biocompatible polymer and an antimicrobial drug for controlled release of the drug is disclosed. The particles may...
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8133870 |
Therapeutic furopyrimidines and thienopyrimidines
The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are...
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8128942 |
Anti-sepsis conjugate vaccine
The present invention provides an immunogenic conjugate comprising biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits thereof,...
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8124589 |
Use of ketogenic compounds for treatment of age-associated memory impairment
This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at...
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8124575 |
Polymeric surfactants based upon alkyl polyglycosides and sugars
The present invention relates to a series of polyglycoside derivatives that are (a) polymeric (that is cross linked with hydroxypropyl linkages) and (b) contain additional functional groups...
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8119142 |
Infant nutritional compositions for preventing obesity
The present invention relates to a method for preventing obesity later in life by administering a certain nutritional composition to an infant with the age between 0 and 36 months. The composition...
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8119607 |
Bicyclic nucleosides and nucleotides as therapeutic agents
The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including...
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8114910 |
Acidic composition
A composition is provided which comprises an acidic component, generally fulvic acid, having a molecular weight not exceeding 20,000 Daltons and a low content of the elements aluminum, mercury,...
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8114856 |
Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
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8110555 |
7-hydroxy chromones as potent antioxidants
The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for...
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8106021 |
Benzylbenzene derivatives and methods of use
Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds,...
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8106023 |
1,4-benzothiepin-1, 1-dioxide derivatives with improved properties method for producing the same, drugs containing said compounds and the use thereof
This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.
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8101583 |
1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof
This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof.
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8101581 |
Use of D-ribose to treat cardiac arrhythmias
D-ribose, given in doses of five to 15 grams daily, reduces or prevents the occurrence of atrial fibrillation in persons experiencing atrial fibrillation.
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8097262 |
Gel type enteral nutrient
An enteral nutrient gel that is excellent at maintaining its solid matter (gel) form in the stomach, does not readily disintegrate or dissolve with a change in pH, is stable in its physical...
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8097592 |
Cocrystal of C-glycoside derivative and L-proline
A cocrystal of (1S)-1,5-anhydro-1-[3-(1-benzothien-2-ylmethyl)-4-fluorophen
yl]-D-glucitol and L-proline. It is a cocrystal of known compound A, which has a constant quality, is superior in storage...
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8097591 |
Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting
The present invention relates to compositions and methods of their production and use, including use in increasing de-N-acetyl sialic acid antigen of a mammalian cell and methods that exploit the...
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8093227 |
Monosaccharide compounds and methods therefor
A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds...
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8093048 |
Methods and compositions for activating regenerative stem cells from bone marrow
The present invention provides novel compositions and methods for pharmaceutical or nutraceutical use in an animal, preferably in a human. In one aspect, compositions and methods are provided for...
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8088743 |
Methods for treating obesity employing an SGLT2 inhibitor
Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in...
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8088742 |
Polyol-glycoside compositions for the skin
The disclosure discusses polyol-glycoside compositions for topical use. The invention provides compositions containing an efficient amount of polyol-glycoside obtained from the acetalization of a...
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8084053 |
Dry mouldable drug formulation
Solid pharmaceutical compositions and methods of making and administering for parenteral injection comprising a binder and at least one therapeutic agent. The pharmaceutical composition has the...
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8076313 |
Composition containing fermentable polysaccharides
The present invention relates to a composition to a nutritional composition comprising 0.1 to 15 gram fermentable e partially hydrolysed gum having a degree of polymerization between 10 and 300 per...
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8071678 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs ...
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8071557 |
Treatment of pulmonary hypertension with carbonic anhydrase inhibitors
This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating...
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8067359 |
Composition for nutritionally improving glucose control and insulin action
Disclosed is a method and composition for nutritionally improving glucose and insulin balance in an individual. The invention further provides a method for treating a comorbidity of diabetes. In...
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8063026 |
Method of palliating lower urinary tract infections by treatment with mannan oligosaccharides
Provided herein are methods of using mannan oligosaccharides, to treat, palliate, relieve, prevent and/or eliminate urinary tract infections of humans. A mixture of oligosaccharides derived from...
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8058234 |
Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
The present invention relates to methods of using lactoferrin (LF) to treat, prevent or reduce the incidence of organ transplant rejection and graft-versus-host-disease. More particularly, the...
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8058246 |
Method and composition to achieve stable color of artificially colored hair
The present invention relates to a composition comprising at least one amylose-containing starch, and its use in extending or improving the color durability and stability of artificially colored...
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8058245 |
Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
The present invention provides fused heterocyclic derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an...
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8053417 |
Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for...
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8048929 |
Hepatitis A viricide
The invention relates to agents which combat the hepatitis A virus, containing only minimal amounts of chlorine-containing and/or chlorine cleaving active ingredients, or none of said substances....
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8044033 |
Fluorocytidine derivatives and COX-2 inhibitors for the treatment of cancer
The present invention provides, in certain embodiments, methods for the treatment of colorectal cancer comprising administering a COX-2 inhibitor and fluorocytidine derivative to a human patient....
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8039441 |
Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as SGLT inhibitors and process for their manufacture
Glucopyranosyl-substituted cyclopropyl-benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The...
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8034576 |
Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
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8034788 |
Composition and methods for skin care
Compositions useful in the treatment of skin atrophy and improvement of skin appearance and texture are disclosed. The methods include the topical administration of vitamin D3 or specific vitamin...
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8029818 |
Method of blunting the postprandial glycemic response to a meal
The present invention relates to a method for reducing the postprandial glycemic excursion to carbohydrates by feeding supplemental fructose prior to the carbohydrate challenge. The unit does of...
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8026220 |
C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and method of using the same to inhibit neoplastic cell growth
Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including...
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8022042 |
Composition and methods for the treatment of cancer
The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor having the structure according to...
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8022101 |
Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing
A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the...
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